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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-43770770-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=43770770&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 43770770,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "ENST00000672860.3",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.64C>G",
"hgvs_p": "p.Arg22Gly",
"transcript": "NM_003376.6",
"protein_id": "NP_003367.4",
"transcript_support_level": null,
"aa_start": 22,
"aa_end": null,
"aa_length": 395,
"cds_start": 64,
"cds_end": null,
"cds_length": 1188,
"cdna_start": 560,
"cdna_end": null,
"cdna_length": 3609,
"mane_select": "ENST00000672860.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.64C>G",
"hgvs_p": "p.Arg22Gly",
"transcript": "ENST00000672860.3",
"protein_id": "ENSP00000500082.3",
"transcript_support_level": null,
"aa_start": 22,
"aa_end": null,
"aa_length": 395,
"cds_start": 64,
"cds_end": null,
"cds_length": 1188,
"cdna_start": 560,
"cdna_end": null,
"cdna_length": 3609,
"mane_select": "NM_003376.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.64C>G",
"hgvs_p": "p.Arg22Gly",
"transcript": "ENST00000372055.9",
"protein_id": "ENSP00000361125.5",
"transcript_support_level": 1,
"aa_start": 22,
"aa_end": null,
"aa_length": 412,
"cds_start": 64,
"cds_end": null,
"cds_length": 1239,
"cdna_start": 64,
"cdna_end": null,
"cdna_length": 1286,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.64C>G",
"hgvs_p": "p.Arg22Gly",
"transcript": "ENST00000425836.9",
"protein_id": "ENSP00000388465.4",
"transcript_support_level": 1,
"aa_start": 22,
"aa_end": null,
"aa_length": 393,
"cds_start": 64,
"cds_end": null,
"cds_length": 1182,
"cdna_start": 560,
"cdna_end": null,
"cdna_length": 3537,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.64C>G",
"hgvs_p": "p.Arg22Gly",
"transcript": "ENST00000413642.8",
"protein_id": "ENSP00000389864.4",
"transcript_support_level": 1,
"aa_start": 22,
"aa_end": null,
"aa_length": 389,
"cds_start": 64,
"cds_end": null,
"cds_length": 1170,
"cdna_start": 64,
"cdna_end": null,
"cdna_length": 1197,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.64C>G",
"hgvs_p": "p.Arg22Gly",
"transcript": "ENST00000372067.8",
"protein_id": "ENSP00000361137.4",
"transcript_support_level": 1,
"aa_start": 22,
"aa_end": null,
"aa_length": 371,
"cds_start": 64,
"cds_end": null,
"cds_length": 1116,
"cdna_start": 558,
"cdna_end": null,
"cdna_length": 3535,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.64C>G",
"hgvs_p": "p.Arg22Gly",
"transcript": "ENST00000482630.7",
"protein_id": "ENSP00000421561.2",
"transcript_support_level": 1,
"aa_start": 22,
"aa_end": null,
"aa_length": 371,
"cds_start": 64,
"cds_end": null,
"cds_length": 1116,
"cdna_start": 64,
"cdna_end": null,
"cdna_length": 1146,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.64C>G",
"hgvs_p": "p.Arg22Gly",
"transcript": "ENST00000417285.7",
"protein_id": "ENSP00000388663.3",
"transcript_support_level": 1,
"aa_start": 22,
"aa_end": null,
"aa_length": 354,
"cds_start": 64,
"cds_end": null,
"cds_length": 1065,
"cdna_start": 64,
"cdna_end": null,
"cdna_length": 1081,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.64C>G",
"hgvs_p": "p.Arg22Gly",
"transcript": "ENST00000372064.9",
"protein_id": "ENSP00000361134.5",
"transcript_support_level": 1,
"aa_start": 22,
"aa_end": null,
"aa_length": 327,
"cds_start": 64,
"cds_end": null,
"cds_length": 984,
"cdna_start": 64,
"cdna_end": null,
"cdna_length": 2909,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.64C>G",
"hgvs_p": "p.Arg22Gly",
"transcript": "ENST00000324450.11",
"protein_id": "ENSP00000317598.7",
"transcript_support_level": 1,
"aa_start": 22,
"aa_end": null,
"aa_length": 317,
"cds_start": 64,
"cds_end": null,
"cds_length": 954,
"cdna_start": 64,
"cdna_end": null,
"cdna_length": 954,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "n.587C>G",
"hgvs_p": null,
"transcript": "ENST00000476772.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1683,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.64C>G",
"hgvs_p": "p.Arg22Gly",
"transcript": "NM_001025366.3",
"protein_id": "NP_001020537.2",
"transcript_support_level": null,
"aa_start": 22,
"aa_end": null,
"aa_length": 412,
"cds_start": 64,
"cds_end": null,
"cds_length": 1239,
"cdna_start": 560,
"cdna_end": null,
"cdna_length": 3660,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.64C>G",
"hgvs_p": "p.Arg22Gly",
"transcript": "NM_001025367.3",
"protein_id": "NP_001020538.2",
"transcript_support_level": null,
"aa_start": 22,
"aa_end": null,
"aa_length": 389,
"cds_start": 64,
"cds_end": null,
"cds_length": 1170,
"cdna_start": 560,
"cdna_end": null,
"cdna_length": 3591,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.64C>G",
"hgvs_p": "p.Arg22Gly",
"transcript": "NM_001025368.3",
"protein_id": "NP_001020539.2",
"transcript_support_level": null,
"aa_start": 22,
"aa_end": null,
"aa_length": 371,
"cds_start": 64,
"cds_end": null,
"cds_length": 1116,
"cdna_start": 560,
"cdna_end": null,
"cdna_length": 3537,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.64C>G",
"hgvs_p": "p.Arg22Gly",
"transcript": "NM_001033756.3",
"protein_id": "NP_001028928.1",
"transcript_support_level": null,
"aa_start": 22,
"aa_end": null,
"aa_length": 371,
"cds_start": 64,
"cds_end": null,
"cds_length": 1116,
"cdna_start": 560,
"cdna_end": null,
"cdna_length": 3471,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.64C>G",
"hgvs_p": "p.Arg22Gly",
"transcript": "NM_001025369.3",
"protein_id": "NP_001020540.2",
"transcript_support_level": null,
"aa_start": 22,
"aa_end": null,
"aa_length": 354,
"cds_start": 64,
"cds_end": null,
"cds_length": 1065,
"cdna_start": 560,
"cdna_end": null,
"cdna_length": 3502,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.64C>G",
"hgvs_p": "p.Arg22Gly",
"transcript": "NM_001204385.2",
"protein_id": "NP_001191314.1",
"transcript_support_level": null,
"aa_start": 22,
"aa_end": null,
"aa_length": 351,
"cds_start": 64,
"cds_end": null,
"cds_length": 1056,
"cdna_start": 560,
"cdna_end": null,
"cdna_length": 3477,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.64C>G",
"hgvs_p": "p.Arg22Gly",
"transcript": "NM_001025370.3",
"protein_id": "NP_001020541.2",
"transcript_support_level": null,
"aa_start": 22,
"aa_end": null,
"aa_length": 327,
"cds_start": 64,
"cds_end": null,
"cds_length": 984,
"cdna_start": 560,
"cdna_end": null,
"cdna_length": 3405,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.64C>G",
"hgvs_p": "p.Arg22Gly",
"transcript": "NM_001171622.2",
"protein_id": "NP_001165093.1",
"transcript_support_level": null,
"aa_start": 22,
"aa_end": null,
"aa_length": 317,
"cds_start": 64,
"cds_end": null,
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"cdna_start": 560,
"cdna_end": null,
"cdna_length": 3375,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.-477C>G",
"hgvs_p": null,
"transcript": "NM_001171623.2",
"protein_id": "NP_001165094.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 232,
"cds_start": -4,
"cds_end": null,
"cds_length": 699,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3660,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.-477C>G",
"hgvs_p": null,
"transcript": "NM_001171624.2",
"protein_id": "NP_001165095.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 215,
"cds_start": -4,
"cds_end": null,
"cds_length": 648,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3609,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.-477C>G",
"hgvs_p": null,
"transcript": "NM_001317010.2",
"protein_id": "NP_001303939.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 213,
"cds_start": -4,
"cds_end": null,
"cds_length": 642,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3537,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VEGFA",
"gene_hgnc_id": 12680,
"hgvs_c": "c.-477C>G",
"hgvs_p": null,
"transcript": "NM_001171625.2",
"protein_id": "NP_001165096.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 209,
"cds_start": -4,
"cds_end": null,
"cds_length": 630,
"cdna_start": null,
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{
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],
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}
],
"message": null
}