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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-52276714-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=52276714&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 52276714,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_001366369.2",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "MCM3",
"gene_hgnc_id": 6945,
"hgvs_c": "c.1166-238A>G",
"hgvs_p": null,
"transcript": "NM_002388.6",
"protein_id": "NP_002379.4",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 808,
"cds_start": null,
"cds_end": null,
"cds_length": 2427,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3068,
"mane_select": "ENST00000596288.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_002388.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "MCM3",
"gene_hgnc_id": 6945,
"hgvs_c": "c.1166-238A>G",
"hgvs_p": null,
"transcript": "ENST00000596288.7",
"protein_id": "ENSP00000472940.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 808,
"cds_start": null,
"cds_end": null,
"cds_length": 2427,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3068,
"mane_select": "NM_002388.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000596288.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "MCM3",
"gene_hgnc_id": 6945,
"hgvs_c": "c.1301-238A>G",
"hgvs_p": null,
"transcript": "ENST00000616552.4",
"protein_id": "ENSP00000480987.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 853,
"cds_start": null,
"cds_end": null,
"cds_length": 2562,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3208,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000616552.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "MCM3",
"gene_hgnc_id": 6945,
"hgvs_c": "c.1196-238A>G",
"hgvs_p": null,
"transcript": "ENST00000229854.12",
"protein_id": "ENSP00000229854.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 818,
"cds_start": null,
"cds_end": null,
"cds_length": 2457,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3095,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000229854.12"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "MCM3",
"gene_hgnc_id": 6945,
"hgvs_c": "c.1166-238A>G",
"hgvs_p": null,
"transcript": "ENST00000860054.1",
"protein_id": "ENSP00000530113.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 839,
"cds_start": null,
"cds_end": null,
"cds_length": 2520,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3229,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000860054.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "MCM3",
"gene_hgnc_id": 6945,
"hgvs_c": "c.1166-238A>G",
"hgvs_p": null,
"transcript": "ENST00000860058.1",
"protein_id": "ENSP00000530117.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 839,
"cds_start": null,
"cds_end": null,
"cds_length": 2520,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3159,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000860058.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "MCM3",
"gene_hgnc_id": 6945,
"hgvs_c": "c.1244-238A>G",
"hgvs_p": null,
"transcript": "ENST00000939873.1",
"protein_id": "ENSP00000609932.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 834,
"cds_start": null,
"cds_end": null,
"cds_length": 2505,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3179,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939873.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "MCM3",
"gene_hgnc_id": 6945,
"hgvs_c": "c.1166-238A>G",
"hgvs_p": null,
"transcript": "NM_001366369.2",
"protein_id": "NP_001353298.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 833,
"cds_start": null,
"cds_end": null,
"cds_length": 2502,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3219,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001366369.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "MCM3",
"gene_hgnc_id": 6945,
"hgvs_c": "c.1166-238A>G",
"hgvs_p": null,
"transcript": "NM_001366370.2",
"protein_id": "NP_001353299.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 825,
"cds_start": null,
"cds_end": null,
"cds_length": 2478,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3119,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001366370.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "MCM3",
"gene_hgnc_id": 6945,
"hgvs_c": "c.1166-238A>G",
"hgvs_p": null,
"transcript": "ENST00000860060.1",
"protein_id": "ENSP00000530119.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 825,
"cds_start": null,
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"cds_length": 2478,
"cdna_start": null,
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"cdna_length": 3064,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000860060.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 17,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "MCM3",
"gene_hgnc_id": 6945,
"hgvs_c": "c.1166-238A>G",
"hgvs_p": null,
"transcript": "ENST00000939874.1",
"protein_id": "ENSP00000609933.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 18,
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"gene_symbol": "MCM3",
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"hgvs_c": "c.1115-238A>G",
"hgvs_p": null,
"transcript": "NM_001366371.2",
"protein_id": "NP_001353300.1",
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "NM_001366371.2"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 17,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "MCM3",
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"hgvs_c": "c.1166-238A>G",
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"transcript": "ENST00000860057.1",
"protein_id": "ENSP00000530116.1",
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"mane_select": null,
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},
{
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],
"exon_rank": null,
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"gene_symbol": "MCM3",
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"feature": "ENST00000939871.1"
},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 17,
"intron_rank": 8,
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"gene_symbol": "MCM3",
"gene_hgnc_id": 6945,
"hgvs_c": "c.1163-238A>G",
"hgvs_p": null,
"transcript": "ENST00000939872.1",
"protein_id": "ENSP00000609931.1",
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},
{
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],
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"gene_symbol": "MCM3",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 8,
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"gene_symbol": "MCM3",
"gene_hgnc_id": 6945,
"hgvs_c": "c.1166-238A>G",
"hgvs_p": null,
"transcript": "ENST00000939881.1",
"protein_id": "ENSP00000609940.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 17,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "MCM3",
"gene_hgnc_id": 6945,
"hgvs_c": "c.1115-238A>G",
"hgvs_p": null,
"transcript": "NM_001366372.2",
"protein_id": "NP_001353301.1",
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},
{
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],
"exon_rank": null,
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"intron_rank": 8,
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"gene_symbol": "MCM3",
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"hgvs_c": "c.1115-238A>G",
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},
{
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"strand": false,
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],
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"intron_rank": 8,
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"gene_symbol": "MCM3",
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},
{
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"strand": false,
"consequences": [
"intron_variant"
],
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"intron_rank": 7,
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"gene_symbol": "MCM3",
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"hgvs_c": "c.1034-238A>G",
"hgvs_p": null,
"transcript": "ENST00000939880.1",
"protein_id": "ENSP00000609939.1",
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000939880.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "MCM3",
"gene_hgnc_id": 6945,
"hgvs_c": "c.1028-238A>G",
"hgvs_p": null,
"transcript": "NM_001270472.3",
"protein_id": "NP_001257401.2",
"transcript_support_level": null,
"aa_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001270472.3"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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