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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-75647742-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=75647742&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 75647742,
"ref": "C",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_015571.4",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.491C>A",
"hgvs_p": "p.Pro164Gln",
"transcript": "NM_015571.4",
"protein_id": "NP_056386.2",
"transcript_support_level": null,
"aa_start": 164,
"aa_end": null,
"aa_length": 1112,
"cds_start": 491,
"cds_end": null,
"cds_length": 3339,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000447266.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015571.4"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.491C>A",
"hgvs_p": "p.Pro164Gln",
"transcript": "ENST00000447266.7",
"protein_id": "ENSP00000402527.2",
"transcript_support_level": 1,
"aa_start": 164,
"aa_end": null,
"aa_length": 1112,
"cds_start": 491,
"cds_end": null,
"cds_length": 3339,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_015571.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000447266.7"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.470C>A",
"hgvs_p": "p.Pro157Gln",
"transcript": "ENST00000370010.6",
"protein_id": "ENSP00000359027.2",
"transcript_support_level": 1,
"aa_start": 157,
"aa_end": null,
"aa_length": 1105,
"cds_start": 470,
"cds_end": null,
"cds_length": 3318,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000370010.6"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.536C>A",
"hgvs_p": "p.Pro179Gln",
"transcript": "ENST00000938450.1",
"protein_id": "ENSP00000608509.1",
"transcript_support_level": null,
"aa_start": 179,
"aa_end": null,
"aa_length": 1127,
"cds_start": 536,
"cds_end": null,
"cds_length": 3384,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938450.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.488C>A",
"hgvs_p": "p.Pro163Gln",
"transcript": "ENST00000898676.1",
"protein_id": "ENSP00000568735.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 1111,
"cds_start": 488,
"cds_end": null,
"cds_length": 3336,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898676.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.491C>A",
"hgvs_p": "p.Pro164Gln",
"transcript": "ENST00000898678.1",
"protein_id": "ENSP00000568737.1",
"transcript_support_level": null,
"aa_start": 164,
"aa_end": null,
"aa_length": 1110,
"cds_start": 491,
"cds_end": null,
"cds_length": 3333,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898678.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.491C>A",
"hgvs_p": "p.Pro164Gln",
"transcript": "ENST00000965019.1",
"protein_id": "ENSP00000635078.1",
"transcript_support_level": null,
"aa_start": 164,
"aa_end": null,
"aa_length": 1110,
"cds_start": 491,
"cds_end": null,
"cds_length": 3333,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965019.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.488C>A",
"hgvs_p": "p.Pro163Gln",
"transcript": "ENST00000898679.1",
"protein_id": "ENSP00000568738.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 1109,
"cds_start": 488,
"cds_end": null,
"cds_length": 3330,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898679.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.491C>A",
"hgvs_p": "p.Pro164Gln",
"transcript": "ENST00000938452.1",
"protein_id": "ENSP00000608511.1",
"transcript_support_level": null,
"aa_start": 164,
"aa_end": null,
"aa_length": 1109,
"cds_start": 491,
"cds_end": null,
"cds_length": 3330,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938452.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.470C>A",
"hgvs_p": "p.Pro157Gln",
"transcript": "NM_001100409.3",
"protein_id": "NP_001093879.1",
"transcript_support_level": null,
"aa_start": 157,
"aa_end": null,
"aa_length": 1105,
"cds_start": 470,
"cds_end": null,
"cds_length": 3318,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001100409.3"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.470C>A",
"hgvs_p": "p.Pro157Gln",
"transcript": "ENST00000965017.1",
"protein_id": "ENSP00000635076.1",
"transcript_support_level": null,
"aa_start": 157,
"aa_end": null,
"aa_length": 1104,
"cds_start": 470,
"cds_end": null,
"cds_length": 3315,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965017.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.470C>A",
"hgvs_p": "p.Pro157Gln",
"transcript": "ENST00000898680.1",
"protein_id": "ENSP00000568739.1",
"transcript_support_level": null,
"aa_start": 157,
"aa_end": null,
"aa_length": 1103,
"cds_start": 470,
"cds_end": null,
"cds_length": 3312,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898680.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.386C>A",
"hgvs_p": "p.Pro129Gln",
"transcript": "ENST00000898683.1",
"protein_id": "ENSP00000568742.1",
"transcript_support_level": null,
"aa_start": 129,
"aa_end": null,
"aa_length": 1077,
"cds_start": 386,
"cds_end": null,
"cds_length": 3234,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898683.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.383C>A",
"hgvs_p": "p.Pro128Gln",
"transcript": "ENST00000965011.1",
"protein_id": "ENSP00000635070.1",
"transcript_support_level": null,
"aa_start": 128,
"aa_end": null,
"aa_length": 1076,
"cds_start": 383,
"cds_end": null,
"cds_length": 3231,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965011.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.488C>A",
"hgvs_p": "p.Pro163Gln",
"transcript": "ENST00000898684.1",
"protein_id": "ENSP00000568743.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 1073,
"cds_start": 488,
"cds_end": null,
"cds_length": 3222,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898684.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.491C>A",
"hgvs_p": "p.Pro164Gln",
"transcript": "ENST00000965013.1",
"protein_id": "ENSP00000635072.1",
"transcript_support_level": null,
"aa_start": 164,
"aa_end": null,
"aa_length": 1072,
"cds_start": 491,
"cds_end": null,
"cds_length": 3219,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965013.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.488C>A",
"hgvs_p": "p.Pro163Gln",
"transcript": "ENST00000898685.1",
"protein_id": "ENSP00000568744.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 1071,
"cds_start": 488,
"cds_end": null,
"cds_length": 3216,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898685.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.365C>A",
"hgvs_p": "p.Pro122Gln",
"transcript": "ENST00000965020.1",
"protein_id": "ENSP00000635079.1",
"transcript_support_level": null,
"aa_start": 122,
"aa_end": null,
"aa_length": 1068,
"cds_start": 365,
"cds_end": null,
"cds_length": 3207,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965020.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.491C>A",
"hgvs_p": "p.Pro164Gln",
"transcript": "ENST00000898681.1",
"protein_id": "ENSP00000568740.1",
"transcript_support_level": null,
"aa_start": 164,
"aa_end": null,
"aa_length": 1066,
"cds_start": 491,
"cds_end": null,
"cds_length": 3201,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898681.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.488C>A",
"hgvs_p": "p.Pro163Gln",
"transcript": "ENST00000898677.1",
"protein_id": "ENSP00000568736.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 1065,
"cds_start": 488,
"cds_end": null,
"cds_length": 3198,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898677.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.470C>A",
"hgvs_p": "p.Pro157Gln",
"transcript": "ENST00000898682.1",
"protein_id": "ENSP00000568741.1",
"transcript_support_level": null,
"aa_start": 157,
"aa_end": null,
"aa_length": 1065,
"cds_start": 470,
"cds_end": null,
"cds_length": 3198,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898682.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP6",
"gene_hgnc_id": 20944,
"hgvs_c": "c.470C>A",
"hgvs_p": "p.Pro157Gln",
"transcript": "ENST00000938451.1",
"protein_id": "ENSP00000608510.1",
"transcript_support_level": null,
"aa_start": 157,
"aa_end": null,
"aa_length": 1059,
"cds_start": 470,
"cds_end": null,
"cds_length": 3180,
"cdna_start": null,
"cdna_end": null,
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}