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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-88144224-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=88144224&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 88144224,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "ENST00000369501.3",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.1051G>C",
"hgvs_p": "p.Val351Leu",
"transcript": "NM_016083.6",
"protein_id": "NP_057167.2",
"transcript_support_level": null,
"aa_start": 351,
"aa_end": null,
"aa_length": 472,
"cds_start": 1051,
"cds_end": null,
"cds_length": 1419,
"cdna_start": 1659,
"cdna_end": null,
"cdna_length": 6019,
"mane_select": "ENST00000369501.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.1051G>C",
"hgvs_p": "p.Val351Leu",
"transcript": "ENST00000369501.3",
"protein_id": "ENSP00000358513.2",
"transcript_support_level": 1,
"aa_start": 351,
"aa_end": null,
"aa_length": 472,
"cds_start": 1051,
"cds_end": null,
"cds_length": 1419,
"cdna_start": 1659,
"cdna_end": null,
"cdna_length": 6019,
"mane_select": "NM_016083.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.1051G>C",
"hgvs_p": "p.Val351Leu",
"transcript": "ENST00000428600.3",
"protein_id": "ENSP00000412192.2",
"transcript_support_level": 1,
"aa_start": 351,
"aa_end": null,
"aa_length": 472,
"cds_start": 1051,
"cds_end": null,
"cds_length": 1419,
"cdna_start": 1182,
"cdna_end": null,
"cdna_length": 5542,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.952G>C",
"hgvs_p": "p.Val318Leu",
"transcript": "ENST00000468898.2",
"protein_id": "ENSP00000420188.1",
"transcript_support_level": 1,
"aa_start": 318,
"aa_end": null,
"aa_length": 439,
"cds_start": 952,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 952,
"cdna_end": null,
"cdna_length": 5312,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.*773G>C",
"hgvs_p": null,
"transcript": "ENST00000362094.6",
"protein_id": "ENSP00000355418.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 36,
"cds_start": -4,
"cds_end": null,
"cds_length": 111,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5244,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.1051G>C",
"hgvs_p": "p.Val351Leu",
"transcript": "NM_001160226.3",
"protein_id": "NP_001153698.1",
"transcript_support_level": null,
"aa_start": 351,
"aa_end": null,
"aa_length": 472,
"cds_start": 1051,
"cds_end": null,
"cds_length": 1419,
"cdna_start": 1802,
"cdna_end": null,
"cdna_length": 6162,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.1051G>C",
"hgvs_p": "p.Val351Leu",
"transcript": "NM_001160258.3",
"protein_id": "NP_001153730.1",
"transcript_support_level": null,
"aa_start": 351,
"aa_end": null,
"aa_length": 472,
"cds_start": 1051,
"cds_end": null,
"cds_length": 1419,
"cdna_start": 1840,
"cdna_end": null,
"cdna_length": 6200,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.1051G>C",
"hgvs_p": "p.Val351Leu",
"transcript": "NM_001160259.3",
"protein_id": "NP_001153731.1",
"transcript_support_level": null,
"aa_start": 351,
"aa_end": null,
"aa_length": 472,
"cds_start": 1051,
"cds_end": null,
"cds_length": 1419,
"cdna_start": 1715,
"cdna_end": null,
"cdna_length": 6075,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.1051G>C",
"hgvs_p": "p.Val351Leu",
"transcript": "NM_001365869.2",
"protein_id": "NP_001352798.1",
"transcript_support_level": null,
"aa_start": 351,
"aa_end": null,
"aa_length": 472,
"cds_start": 1051,
"cds_end": null,
"cds_length": 1419,
"cdna_start": 1697,
"cdna_end": null,
"cdna_length": 6057,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.1051G>C",
"hgvs_p": "p.Val351Leu",
"transcript": "NM_001365870.2",
"protein_id": "NP_001352799.1",
"transcript_support_level": null,
"aa_start": 351,
"aa_end": null,
"aa_length": 472,
"cds_start": 1051,
"cds_end": null,
"cds_length": 1419,
"cdna_start": 1850,
"cdna_end": null,
"cdna_length": 6210,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.1051G>C",
"hgvs_p": "p.Val351Leu",
"transcript": "NM_001365872.2",
"protein_id": "NP_001352801.1",
"transcript_support_level": null,
"aa_start": 351,
"aa_end": null,
"aa_length": 472,
"cds_start": 1051,
"cds_end": null,
"cds_length": 1419,
"cdna_start": 2046,
"cdna_end": null,
"cdna_length": 6406,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.1051G>C",
"hgvs_p": "p.Val351Leu",
"transcript": "NM_001365874.3",
"protein_id": "NP_001352803.1",
"transcript_support_level": null,
"aa_start": 351,
"aa_end": null,
"aa_length": 472,
"cds_start": 1051,
"cds_end": null,
"cds_length": 1419,
"cdna_start": 1182,
"cdna_end": null,
"cdna_length": 5542,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.1051G>C",
"hgvs_p": "p.Val351Leu",
"transcript": "NM_001370545.1",
"protein_id": "NP_001357474.1",
"transcript_support_level": null,
"aa_start": 351,
"aa_end": null,
"aa_length": 472,
"cds_start": 1051,
"cds_end": null,
"cds_length": 1419,
"cdna_start": 1191,
"cdna_end": null,
"cdna_length": 5551,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.1051G>C",
"hgvs_p": "p.Val351Leu",
"transcript": "NM_001370546.1",
"protein_id": "NP_001357475.1",
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"cdna_start": 1274,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.1051G>C",
"hgvs_p": "p.Val351Leu",
"transcript": "NM_001370547.1",
"protein_id": "NP_001357476.1",
"transcript_support_level": null,
"aa_start": 351,
"aa_end": null,
"aa_length": 472,
"cds_start": 1051,
"cds_end": null,
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"cdna_start": 1503,
"cdna_end": null,
"cdna_length": 5863,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.1051G>C",
"hgvs_p": "p.Val351Leu",
"transcript": "NM_001424094.1",
"protein_id": "NP_001411023.1",
"transcript_support_level": null,
"aa_start": 351,
"aa_end": null,
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"cds_start": 1051,
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"cdna_start": 1455,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.1051G>C",
"hgvs_p": "p.Val351Leu",
"transcript": "NM_001424095.1",
"protein_id": "NP_001411024.1",
"transcript_support_level": null,
"aa_start": 351,
"aa_end": null,
"aa_length": 472,
"cds_start": 1051,
"cds_end": null,
"cds_length": 1419,
"cdna_start": 1449,
"cdna_end": null,
"cdna_length": 5809,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.1051G>C",
"hgvs_p": "p.Val351Leu",
"transcript": "NM_001424096.1",
"protein_id": "NP_001411025.1",
"transcript_support_level": null,
"aa_start": 351,
"aa_end": null,
"aa_length": 472,
"cds_start": 1051,
"cds_end": null,
"cds_length": 1419,
"cdna_start": 1258,
"cdna_end": null,
"cdna_length": 5618,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.1051G>C",
"hgvs_p": "p.Val351Leu",
"transcript": "NM_001424097.1",
"protein_id": "NP_001411026.1",
"transcript_support_level": null,
"aa_start": 351,
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"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.1051G>C",
"hgvs_p": "p.Val351Leu",
"transcript": "NM_001424098.1",
"protein_id": "NP_001411027.1",
"transcript_support_level": null,
"aa_start": 351,
"aa_end": null,
"aa_length": 472,
"cds_start": 1051,
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"cdna_start": 1888,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.1051G>C",
"hgvs_p": "p.Val351Leu",
"transcript": "ENST00000369499.3",
"protein_id": "ENSP00000358511.2",
"transcript_support_level": 5,
"aa_start": 351,
"aa_end": null,
"aa_length": 472,
"cds_start": 1051,
"cds_end": null,
"cds_length": 1419,
"cdna_start": 1201,
"cdna_end": null,
"cdna_length": 5561,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 1,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.1051G>C",
"hgvs_p": "p.Val351Leu",
"transcript": "ENST00000549890.2",
"protein_id": "ENSP00000446819.1",
"transcript_support_level": 6,
"aa_start": 351,
"aa_end": null,
"aa_length": 472,
"cds_start": 1051,
"cds_end": null,
"cds_length": 1419,
"cdna_start": 1142,
"cdna_end": null,
"cdna_length": 5502,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNR1",
"gene_hgnc_id": 2159,
"hgvs_c": "c.1051G>C",
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"verdict": "Uncertain_significance",
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{
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"clinvar_review_status": "",
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"pathogenicity_classification_combined": null,
"custom_annotations": null
}
],
"message": null
}