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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 7-100679371-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=100679371&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "7",
"pos": 100679371,
"ref": "A",
"alt": "C",
"effect": "downstream_gene_variant",
"transcript": "NM_001375759.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"downstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIGYF1",
"gene_hgnc_id": 9126,
"hgvs_c": "c.*2348T>G",
"hgvs_p": null,
"transcript": "NM_001375765.1",
"protein_id": "NP_001362694.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1035,
"cds_start": null,
"cds_end": null,
"cds_length": 3108,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000678049.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001375765.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"downstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIGYF1",
"gene_hgnc_id": 9126,
"hgvs_c": "c.*2348T>G",
"hgvs_p": null,
"transcript": "ENST00000678049.1",
"protein_id": "ENSP00000503354.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1035,
"cds_start": null,
"cds_end": null,
"cds_length": 3108,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001375765.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000678049.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"downstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNB2",
"gene_hgnc_id": 4398,
"hgvs_c": "c.*570A>C",
"hgvs_p": null,
"transcript": "NM_005273.4",
"protein_id": "NP_005264.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 340,
"cds_start": null,
"cds_end": null,
"cds_length": 1023,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000303210.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_005273.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"downstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNB2",
"gene_hgnc_id": 4398,
"hgvs_c": "c.*570A>C",
"hgvs_p": null,
"transcript": "ENST00000303210.9",
"protein_id": "ENSP00000305260.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 340,
"cds_start": null,
"cds_end": null,
"cds_length": 1023,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_005273.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000303210.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"downstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIGYF1",
"gene_hgnc_id": 9126,
"hgvs_c": "c.*2348T>G",
"hgvs_p": null,
"transcript": "ENST00000275732.5",
"protein_id": "ENSP00000275732.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1035,
"cds_start": null,
"cds_end": null,
"cds_length": 3108,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000275732.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"downstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNB2",
"gene_hgnc_id": 4398,
"hgvs_c": "c.*570A>C",
"hgvs_p": null,
"transcript": "ENST00000393924.1",
"protein_id": "ENSP00000377501.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 340,
"cds_start": null,
"cds_end": null,
"cds_length": 1023,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000393924.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"downstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIGYF1",
"gene_hgnc_id": 9126,
"hgvs_c": "c.*2317T>G",
"hgvs_p": null,
"transcript": "NM_001375759.1",
"protein_id": "NP_001362688.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1076,
"cds_start": null,
"cds_end": null,
"cds_length": 3231,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001375759.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"downstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIGYF1",
"gene_hgnc_id": 9126,
"hgvs_c": "c.*2317T>G",
"hgvs_p": null,
"transcript": "NM_001375760.1",
"protein_id": "NP_001362689.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1076,
"cds_start": null,
"cds_end": null,
"cds_length": 3231,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001375760.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"downstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIGYF1",
"gene_hgnc_id": 9126,
"hgvs_c": "c.*2317T>G",
"hgvs_p": null,
"transcript": "NM_001375761.1",
"protein_id": "NP_001362690.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1076,
"cds_start": null,
"cds_end": null,
"cds_length": 3231,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001375761.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"downstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIGYF1",
"gene_hgnc_id": 9126,
"hgvs_c": "c.*2317T>G",
"hgvs_p": null,
"transcript": "NM_001375762.1",
"protein_id": "NP_001362691.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1076,
"cds_start": null,
"cds_end": null,
"cds_length": 3231,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001375762.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"downstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIGYF1",
"gene_hgnc_id": 9126,
"hgvs_c": "c.*2317T>G",
"hgvs_p": null,
"transcript": "NM_001375763.1",
"protein_id": "NP_001362692.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1076,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001375763.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"downstream_gene_variant"
],
"exon_rank": null,
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"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIGYF1",
"gene_hgnc_id": 9126,
"hgvs_c": "c.*2317T>G",
"hgvs_p": null,
"transcript": "NM_001375764.1",
"protein_id": "NP_001362693.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001375764.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"downstream_gene_variant"
],
"exon_rank": null,
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"exon_count": 27,
"intron_rank": null,
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"gene_symbol": "GIGYF1",
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"hgvs_c": "c.*2317T>G",
"hgvs_p": null,
"transcript": "NM_001375767.1",
"protein_id": "NP_001362696.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "NM_001375767.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": null,
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"gene_symbol": "GIGYF1",
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"transcript": "NM_001375768.1",
"protein_id": "NP_001362697.1",
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"biotype": "protein_coding",
"feature": "NM_001375768.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"downstream_gene_variant"
],
"exon_rank": null,
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"exon_count": 28,
"intron_rank": null,
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"gene_symbol": "GIGYF1",
"gene_hgnc_id": 9126,
"hgvs_c": "c.*2348T>G",
"hgvs_p": null,
"transcript": "NM_001375766.1",
"protein_id": "NP_001362695.1",
"transcript_support_level": null,
"aa_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "NM_001375766.1"
},
{
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"protein_coding": true,
"strand": true,
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"downstream_gene_variant"
],
"exon_rank": null,
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"intron_rank": null,
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"gene_symbol": "GIGYF1",
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"hgvs_c": "c.*2348T>G",
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"transcript": "ENST00000646601.1",
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"biotype": "protein_coding",
"feature": "ENST00000646601.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 27,
"intron_rank": null,
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"gene_symbol": "GIGYF1",
"gene_hgnc_id": 9126,
"hgvs_c": "c.*2348T>G",
"hgvs_p": null,
"transcript": "ENST00000925356.1",
"protein_id": "ENSP00000595415.1",
"transcript_support_level": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000925356.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 25,
"intron_rank": null,
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"gene_symbol": "GIGYF1",
"gene_hgnc_id": 9126,
"hgvs_c": "c.*2348T>G",
"hgvs_p": null,
"transcript": "ENST00000961707.1",
"protein_id": "ENSP00000631766.1",
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},
{
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],
"exon_rank": null,
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"intron_rank": null,
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"gene_symbol": "GIGYF1",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"intron_rank": null,
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"gene_symbol": "GIGYF1",
"gene_hgnc_id": 9126,
"hgvs_c": "c.*2348T>G",
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"transcript": "ENST00000925357.1",
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},
{
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"strand": true,
"consequences": [
"downstream_gene_variant"
],
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"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNB2",
"gene_hgnc_id": 4398,
"hgvs_c": "c.*570A>C",
"hgvs_p": null,
"transcript": "ENST00000879679.1",
"protein_id": "ENSP00000549738.1",
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"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000879679.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"downstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNB2",
"gene_hgnc_id": 4398,
"hgvs_c": "c.*570A>C",
"hgvs_p": null,
"transcript": "ENST00000879684.1",
"protein_id": "ENSP00000549743.1",
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"aa_start": null,
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"aa_length": 344,
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "ENST00000879684.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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}