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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 7-103086667-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=103086667&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "7",
"pos": 103086667,
"ref": "C",
"alt": "A",
"effect": "missense_variant",
"transcript": "ENST00000323716.8",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.431C>A",
"hgvs_p": "p.Ala144Glu",
"transcript": "NM_031905.5",
"protein_id": "NP_114111.2",
"transcript_support_level": null,
"aa_start": 144,
"aa_end": null,
"aa_length": 343,
"cds_start": 431,
"cds_end": null,
"cds_length": 1032,
"cdna_start": 564,
"cdna_end": null,
"cdna_length": 2371,
"mane_select": "ENST00000323716.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.431C>A",
"hgvs_p": "p.Ala144Glu",
"transcript": "ENST00000323716.8",
"protein_id": "ENSP00000319412.3",
"transcript_support_level": 1,
"aa_start": 144,
"aa_end": null,
"aa_length": 343,
"cds_start": 431,
"cds_end": null,
"cds_length": 1032,
"cdna_start": 564,
"cdna_end": null,
"cdna_length": 2371,
"mane_select": "NM_031905.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.326C>A",
"hgvs_p": "p.Ala109Glu",
"transcript": "ENST00000441711.6",
"protein_id": "ENSP00000413619.2",
"transcript_support_level": 1,
"aa_start": 109,
"aa_end": null,
"aa_length": 308,
"cds_start": 326,
"cds_end": null,
"cds_length": 927,
"cdna_start": 718,
"cdna_end": null,
"cdna_length": 2524,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.431C>A",
"hgvs_p": "p.Ala144Glu",
"transcript": "ENST00000428183.6",
"protein_id": "ENSP00000396654.2",
"transcript_support_level": 1,
"aa_start": 144,
"aa_end": null,
"aa_length": 284,
"cds_start": 431,
"cds_end": null,
"cds_length": 855,
"cdna_start": 823,
"cdna_end": null,
"cdna_length": 2445,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.326C>A",
"hgvs_p": "p.Ala109Glu",
"transcript": "ENST00000454559.5",
"protein_id": "ENSP00000405612.1",
"transcript_support_level": 1,
"aa_start": 109,
"aa_end": null,
"aa_length": 249,
"cds_start": 326,
"cds_end": null,
"cds_length": 750,
"cdna_start": 718,
"cdna_end": null,
"cdna_length": 2347,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.326C>A",
"hgvs_p": "p.Ala109Glu",
"transcript": "ENST00000541300.5",
"protein_id": "ENSP00000440463.1",
"transcript_support_level": 1,
"aa_start": 109,
"aa_end": null,
"aa_length": 225,
"cds_start": 326,
"cds_end": null,
"cds_length": 678,
"cdna_start": 718,
"cdna_end": null,
"cdna_length": 2266,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.326C>A",
"hgvs_p": "p.Ala109Glu",
"transcript": "NM_001161009.3",
"protein_id": "NP_001154481.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 308,
"cds_start": 326,
"cds_end": null,
"cds_length": 927,
"cdna_start": 459,
"cdna_end": null,
"cdna_length": 2266,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.431C>A",
"hgvs_p": "p.Ala144Glu",
"transcript": "NM_001161010.3",
"protein_id": "NP_001154482.1",
"transcript_support_level": null,
"aa_start": 144,
"aa_end": null,
"aa_length": 284,
"cds_start": 431,
"cds_end": null,
"cds_length": 855,
"cdna_start": 564,
"cdna_end": null,
"cdna_length": 2194,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.326C>A",
"hgvs_p": "p.Ala109Glu",
"transcript": "NM_001161011.3",
"protein_id": "NP_001154483.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 284,
"cds_start": 326,
"cds_end": null,
"cds_length": 855,
"cdna_start": 459,
"cdna_end": null,
"cdna_length": 2194,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.326C>A",
"hgvs_p": "p.Ala109Glu",
"transcript": "ENST00000425331.5",
"protein_id": "ENSP00000397969.1",
"transcript_support_level": 2,
"aa_start": 109,
"aa_end": null,
"aa_length": 284,
"cds_start": 326,
"cds_end": null,
"cds_length": 855,
"cdna_start": 718,
"cdna_end": null,
"cdna_length": 2443,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.326C>A",
"hgvs_p": "p.Ala109Glu",
"transcript": "NM_001161012.3",
"protein_id": "NP_001154484.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 249,
"cds_start": 326,
"cds_end": null,
"cds_length": 750,
"cdna_start": 459,
"cdna_end": null,
"cdna_length": 2089,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.464C>A",
"hgvs_p": "p.Ala155Glu",
"transcript": "ENST00000434153.1",
"protein_id": "ENSP00000398201.1",
"transcript_support_level": 5,
"aa_start": 155,
"aa_end": null,
"aa_length": 232,
"cds_start": 464,
"cds_end": null,
"cds_length": 700,
"cdna_start": 569,
"cdna_end": null,
"cdna_length": 805,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.326C>A",
"hgvs_p": "p.Ala109Glu",
"transcript": "NM_001161013.3",
"protein_id": "NP_001154485.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 225,
"cds_start": 326,
"cds_end": null,
"cds_length": 678,
"cdna_start": 459,
"cdna_end": null,
"cdna_length": 2017,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.29C>A",
"hgvs_p": "p.Ala10Glu",
"transcript": "ENST00000431642.1",
"protein_id": "ENSP00000406840.1",
"transcript_support_level": 3,
"aa_start": 10,
"aa_end": null,
"aa_length": 185,
"cds_start": 29,
"cds_end": null,
"cds_length": 558,
"cdna_start": 29,
"cdna_end": null,
"cdna_length": 688,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.545C>A",
"hgvs_p": "p.Ala182Glu",
"transcript": "XM_047420912.1",
"protein_id": "XP_047276868.1",
"transcript_support_level": null,
"aa_start": 182,
"aa_end": null,
"aa_length": 381,
"cds_start": 545,
"cds_end": null,
"cds_length": 1146,
"cdna_start": 678,
"cdna_end": null,
"cdna_length": 2485,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.524C>A",
"hgvs_p": "p.Ala175Glu",
"transcript": "XM_047420913.1",
"protein_id": "XP_047276869.1",
"transcript_support_level": null,
"aa_start": 175,
"aa_end": null,
"aa_length": 374,
"cds_start": 524,
"cds_end": null,
"cds_length": 1125,
"cdna_start": 657,
"cdna_end": null,
"cdna_length": 2464,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.545C>A",
"hgvs_p": "p.Ala182Glu",
"transcript": "XM_047420914.1",
"protein_id": "XP_047276870.1",
"transcript_support_level": null,
"aa_start": 182,
"aa_end": null,
"aa_length": 357,
"cds_start": 545,
"cds_end": null,
"cds_length": 1074,
"cdna_start": 678,
"cdna_end": null,
"cdna_length": 2413,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.458C>A",
"hgvs_p": "p.Ala153Glu",
"transcript": "XM_017012684.3",
"protein_id": "XP_016868173.1",
"transcript_support_level": null,
"aa_start": 153,
"aa_end": null,
"aa_length": 352,
"cds_start": 458,
"cds_end": null,
"cds_length": 1059,
"cdna_start": 591,
"cdna_end": null,
"cdna_length": 2398,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.458C>A",
"hgvs_p": "p.Ala153Glu",
"transcript": "XM_017012685.3",
"protein_id": "XP_016868174.1",
"transcript_support_level": null,
"aa_start": 153,
"aa_end": null,
"aa_length": 328,
"cds_start": 458,
"cds_end": null,
"cds_length": 987,
"cdna_start": 591,
"cdna_end": null,
"cdna_length": 2326,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.545C>A",
"hgvs_p": "p.Ala182Glu",
"transcript": "XM_047420915.1",
"protein_id": "XP_047276871.1",
"transcript_support_level": null,
"aa_start": 182,
"aa_end": null,
"aa_length": 322,
"cds_start": 545,
"cds_end": null,
"cds_length": 969,
"cdna_start": 678,
"cdna_end": null,
"cdna_length": 2308,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.431C>A",
"hgvs_p": "p.Ala144Glu",
"transcript": "XM_047420916.1",
"protein_id": "XP_047276872.1",
"transcript_support_level": null,
"aa_start": 144,
"aa_end": null,
"aa_length": 319,
"cds_start": 431,
"cds_end": null,
"cds_length": 960,
"cdna_start": 564,
"cdna_end": null,
"cdna_length": 2299,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.350C>A",
"hgvs_p": "p.Ala117Glu",
"transcript": "XM_011516601.4",
"protein_id": "XP_011514903.1",
"transcript_support_level": null,
"aa_start": 117,
"aa_end": null,
"aa_length": 316,
"cds_start": 350,
"cds_end": null,
"cds_length": 951,
"cdna_start": 483,
"cdna_end": null,
"cdna_length": 2290,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARMC10",
"gene_hgnc_id": 21706,
"hgvs_c": "c.524C>A",
"hgvs_p": "p.Ala175Glu",
"transcript": "XM_047420917.1",
"protein_id": "XP_047276873.1",
"transcript_support_level": null,
"aa_start": 175,
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}
],
"message": null
}