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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 7-106263458-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=106263458&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "7",
"pos": 106263458,
"ref": "T",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "NM_005746.3",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.903A>G",
"hgvs_p": "p.Ser301Ser",
"transcript": "NM_005746.3",
"protein_id": "NP_005737.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 491,
"cds_start": 903,
"cds_end": null,
"cds_length": 1476,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000222553.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_005746.3"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.903A>G",
"hgvs_p": "p.Ser301Ser",
"transcript": "ENST00000222553.8",
"protein_id": "ENSP00000222553.3",
"transcript_support_level": 1,
"aa_start": 301,
"aa_end": null,
"aa_length": 491,
"cds_start": 903,
"cds_end": null,
"cds_length": 1476,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_005746.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000222553.8"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.903A>G",
"hgvs_p": "p.Ser301Ser",
"transcript": "ENST00000354289.9",
"protein_id": "ENSP00000346242.4",
"transcript_support_level": 1,
"aa_start": 301,
"aa_end": null,
"aa_length": 368,
"cds_start": 903,
"cds_end": null,
"cds_length": 1107,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000354289.9"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.903A>G",
"hgvs_p": "p.Ser301Ser",
"transcript": "ENST00000968694.1",
"protein_id": "ENSP00000638753.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 510,
"cds_start": 903,
"cds_end": null,
"cds_length": 1533,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968694.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.903A>G",
"hgvs_p": "p.Ser301Ser",
"transcript": "ENST00000424768.2",
"protein_id": "ENSP00000390591.2",
"transcript_support_level": 4,
"aa_start": 301,
"aa_end": null,
"aa_length": 491,
"cds_start": 903,
"cds_end": null,
"cds_length": 1476,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000424768.2"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.903A>G",
"hgvs_p": "p.Ser301Ser",
"transcript": "ENST00000681255.1",
"protein_id": "ENSP00000506129.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 491,
"cds_start": 903,
"cds_end": null,
"cds_length": 1476,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000681255.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.903A>G",
"hgvs_p": "p.Ser301Ser",
"transcript": "ENST00000681491.1",
"protein_id": "ENSP00000506540.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 491,
"cds_start": 903,
"cds_end": null,
"cds_length": 1476,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000681491.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.903A>G",
"hgvs_p": "p.Ser301Ser",
"transcript": "ENST00000901886.1",
"protein_id": "ENSP00000571945.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 491,
"cds_start": 903,
"cds_end": null,
"cds_length": 1476,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000901886.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.903A>G",
"hgvs_p": "p.Ser301Ser",
"transcript": "ENST00000901887.1",
"protein_id": "ENSP00000571946.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 491,
"cds_start": 903,
"cds_end": null,
"cds_length": 1476,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000901887.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.903A>G",
"hgvs_p": "p.Ser301Ser",
"transcript": "ENST00000921397.1",
"protein_id": "ENSP00000591456.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 491,
"cds_start": 903,
"cds_end": null,
"cds_length": 1476,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000921397.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.900A>G",
"hgvs_p": "p.Ser300Ser",
"transcript": "ENST00000680584.1",
"protein_id": "ENSP00000505012.1",
"transcript_support_level": null,
"aa_start": 300,
"aa_end": null,
"aa_length": 490,
"cds_start": 900,
"cds_end": null,
"cds_length": 1473,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000680584.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.894A>G",
"hgvs_p": "p.Ser298Ser",
"transcript": "ENST00000681878.1",
"protein_id": "ENSP00000505577.1",
"transcript_support_level": null,
"aa_start": 298,
"aa_end": null,
"aa_length": 488,
"cds_start": 894,
"cds_end": null,
"cds_length": 1467,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000681878.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.903A>G",
"hgvs_p": "p.Ser301Ser",
"transcript": "ENST00000680468.1",
"protein_id": "ENSP00000505172.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 464,
"cds_start": 903,
"cds_end": null,
"cds_length": 1395,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000680468.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.903A>G",
"hgvs_p": "p.Ser301Ser",
"transcript": "ENST00000679951.1",
"protein_id": "ENSP00000505427.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 444,
"cds_start": 903,
"cds_end": null,
"cds_length": 1335,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000679951.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.705A>G",
"hgvs_p": "p.Ser235Ser",
"transcript": "ENST00000680786.1",
"protein_id": "ENSP00000505453.1",
"transcript_support_level": null,
"aa_start": 235,
"aa_end": null,
"aa_length": 425,
"cds_start": 705,
"cds_end": null,
"cds_length": 1278,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000680786.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.642A>G",
"hgvs_p": "p.Ser214Ser",
"transcript": "ENST00000679643.1",
"protein_id": "ENSP00000504962.1",
"transcript_support_level": null,
"aa_start": 214,
"aa_end": null,
"aa_length": 404,
"cds_start": 642,
"cds_end": null,
"cds_length": 1215,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000679643.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.642A>G",
"hgvs_p": "p.Ser214Ser",
"transcript": "ENST00000491027.6",
"protein_id": "ENSP00000506343.1",
"transcript_support_level": 2,
"aa_start": 214,
"aa_end": null,
"aa_length": 241,
"cds_start": 642,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000491027.6"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.903A>G",
"hgvs_p": "p.Ser301Ser",
"transcript": "XM_047419699.1",
"protein_id": "XP_047275655.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 491,
"cds_start": 903,
"cds_end": null,
"cds_length": 1476,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047419699.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.-199A>G",
"hgvs_p": null,
"transcript": "ENST00000680823.1",
"protein_id": "ENSP00000506618.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 124,
"cds_start": null,
"cds_end": null,
"cds_length": 375,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000680823.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.-199A>G",
"hgvs_p": null,
"transcript": "ENST00000681550.1",
"protein_id": "ENSP00000505112.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 124,
"cds_start": null,
"cds_end": null,
"cds_length": 375,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000681550.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.-199A>G",
"hgvs_p": null,
"transcript": "ENST00000681936.1",
"protein_id": "ENSP00000504973.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 124,
"cds_start": null,
"cds_end": null,
"cds_length": 375,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000681936.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "n.828A>G",
"hgvs_p": null,
"transcript": "ENST00000484527.6",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000484527.6"
},
{
"aa_ref": null,
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}