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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 7-106278476-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=106278476&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "7",
"pos": 106278476,
"ref": "A",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000222553.8",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.58-1297T>G",
"hgvs_p": null,
"transcript": "NM_005746.3",
"protein_id": "NP_005737.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 491,
"cds_start": -4,
"cds_end": null,
"cds_length": 1476,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4360,
"mane_select": "ENST00000222553.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.58-1297T>G",
"hgvs_p": null,
"transcript": "ENST00000222553.8",
"protein_id": "ENSP00000222553.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 491,
"cds_start": -4,
"cds_end": null,
"cds_length": 1476,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4360,
"mane_select": "NM_005746.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.58-1297T>G",
"hgvs_p": null,
"transcript": "ENST00000354289.9",
"protein_id": "ENSP00000346242.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 368,
"cds_start": -4,
"cds_end": null,
"cds_length": 1107,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1495,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.58-1297T>G",
"hgvs_p": null,
"transcript": "ENST00000424768.2",
"protein_id": "ENSP00000390591.2",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": 491,
"cds_start": -4,
"cds_end": null,
"cds_length": 1476,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4769,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.58-1297T>G",
"hgvs_p": null,
"transcript": "ENST00000681255.1",
"protein_id": "ENSP00000506129.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 491,
"cds_start": -4,
"cds_end": null,
"cds_length": 1476,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4700,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.58-1297T>G",
"hgvs_p": null,
"transcript": "ENST00000681491.1",
"protein_id": "ENSP00000506540.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 491,
"cds_start": -4,
"cds_end": null,
"cds_length": 1476,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4477,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.58-1297T>G",
"hgvs_p": null,
"transcript": "ENST00000680584.1",
"protein_id": "ENSP00000505012.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 490,
"cds_start": -4,
"cds_end": null,
"cds_length": 1473,
"cdna_start": null,
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"cdna_length": 4457,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.58-1297T>G",
"hgvs_p": null,
"transcript": "ENST00000681878.1",
"protein_id": "ENSP00000505577.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 488,
"cds_start": -4,
"cds_end": null,
"cds_length": 1467,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2598,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.58-1297T>G",
"hgvs_p": null,
"transcript": "ENST00000680468.1",
"protein_id": "ENSP00000505172.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 464,
"cds_start": -4,
"cds_end": null,
"cds_length": 1395,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4389,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
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"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.58-1297T>G",
"hgvs_p": null,
"transcript": "ENST00000679951.1",
"protein_id": "ENSP00000505427.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "NAMPT",
"gene_hgnc_id": 30092,
"hgvs_c": "c.-160-1297T>G",
"hgvs_p": null,
"transcript": "ENST00000680786.1",
"protein_id": "ENSP00000505453.1",
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},
{
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"consequences": [
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],
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"gene_symbol": "NAMPT",
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},
{
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],
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"gene_symbol": "NAMPT",
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"hgvs_c": "c.58-5818T>G",
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"transcript": "ENST00000491027.6",
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},
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],
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"gene_symbol": "NAMPT",
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},
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],
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},
{
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],
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],
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},
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],
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"gene_symbol": "NAMPT",
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"hgvs_c": "c.-1041-1297T>G",
"hgvs_p": null,
"transcript": "ENST00000681936.1",
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},
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],
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],
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],
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"gene_symbol": "NAMPT",
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},
{
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"strand": false,
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],
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"intron_rank": 1,
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"gene_symbol": "NAMPT",
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"hgvs_c": "n.58-1297T>G",
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