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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 7-117130530-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=117130530&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "7",
"pos": 117130530,
"ref": "T",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "ENST00000323984.8",
"consequences": [
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7",
"gene_hgnc_id": 11351,
"hgvs_c": "c.489T>C",
"hgvs_p": "p.Tyr163Tyr",
"transcript": "NM_001369598.1",
"protein_id": "NP_001356527.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 577,
"cds_start": 489,
"cds_end": null,
"cds_length": 1734,
"cdna_start": 529,
"cdna_end": null,
"cdna_length": 2093,
"mane_select": "ENST00000323984.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7",
"gene_hgnc_id": 11351,
"hgvs_c": "c.489T>C",
"hgvs_p": "p.Tyr163Tyr",
"transcript": "ENST00000323984.8",
"protein_id": "ENSP00000325673.3",
"transcript_support_level": 5,
"aa_start": 163,
"aa_end": null,
"aa_length": 577,
"cds_start": 489,
"cds_end": null,
"cds_length": 1734,
"cdna_start": 529,
"cdna_end": null,
"cdna_length": 2093,
"mane_select": "NM_001369598.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7",
"gene_hgnc_id": 11351,
"hgvs_c": "c.489T>C",
"hgvs_p": "p.Tyr163Tyr",
"transcript": "ENST00000265437.9",
"protein_id": "ENSP00000265437.5",
"transcript_support_level": 1,
"aa_start": 163,
"aa_end": null,
"aa_length": 585,
"cds_start": 489,
"cds_end": null,
"cds_length": 1758,
"cdna_start": 703,
"cdna_end": null,
"cdna_length": 2899,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7",
"gene_hgnc_id": 11351,
"hgvs_c": "c.489T>C",
"hgvs_p": "p.Tyr163Tyr",
"transcript": "ENST00000393451.7",
"protein_id": "ENSP00000377097.3",
"transcript_support_level": 1,
"aa_start": 163,
"aa_end": null,
"aa_length": 554,
"cds_start": 489,
"cds_end": null,
"cds_length": 1665,
"cdna_start": 688,
"cdna_end": null,
"cdna_length": 2110,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7",
"gene_hgnc_id": 11351,
"hgvs_c": "c.360T>C",
"hgvs_p": "p.Tyr120Tyr",
"transcript": "ENST00000393447.8",
"protein_id": "ENSP00000377093.4",
"transcript_support_level": 1,
"aa_start": 120,
"aa_end": null,
"aa_length": 534,
"cds_start": 360,
"cds_end": null,
"cds_length": 1605,
"cdna_start": 691,
"cdna_end": null,
"cdna_length": 2182,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7",
"gene_hgnc_id": 11351,
"hgvs_c": "c.360T>C",
"hgvs_p": "p.Tyr120Tyr",
"transcript": "ENST00000393444.7",
"protein_id": "ENSP00000377090.3",
"transcript_support_level": 1,
"aa_start": 120,
"aa_end": null,
"aa_length": 511,
"cds_start": 360,
"cds_end": null,
"cds_length": 1536,
"cdna_start": 691,
"cdna_end": null,
"cdna_length": 2113,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"splice_region_variant",
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7-AS2",
"gene_hgnc_id": 16044,
"hgvs_c": "n.410A>G",
"hgvs_p": null,
"transcript": "ENST00000434993.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 918,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7",
"gene_hgnc_id": 11351,
"hgvs_c": "n.130T>C",
"hgvs_p": null,
"transcript": "ENST00000489293.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 904,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ST7-AS2",
"gene_hgnc_id": 16044,
"hgvs_c": "n.250+13637A>G",
"hgvs_p": null,
"transcript": "ENST00000432541.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1279,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7",
"gene_hgnc_id": 11351,
"hgvs_c": "c.489T>C",
"hgvs_p": "p.Tyr163Tyr",
"transcript": "NM_021908.3",
"protein_id": "NP_068708.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 585,
"cds_start": 489,
"cds_end": null,
"cds_length": 1758,
"cdna_start": 529,
"cdna_end": null,
"cdna_length": 2725,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7",
"gene_hgnc_id": 11351,
"hgvs_c": "c.489T>C",
"hgvs_p": "p.Tyr163Tyr",
"transcript": "NM_001369601.1",
"protein_id": "NP_001356530.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 572,
"cds_start": 489,
"cds_end": null,
"cds_length": 1719,
"cdna_start": 529,
"cdna_end": null,
"cdna_length": 2078,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7",
"gene_hgnc_id": 11351,
"hgvs_c": "c.489T>C",
"hgvs_p": "p.Tyr163Tyr",
"transcript": "ENST00000393449.5",
"protein_id": "ENSP00000377095.1",
"transcript_support_level": 5,
"aa_start": 163,
"aa_end": null,
"aa_length": 572,
"cds_start": 489,
"cds_end": null,
"cds_length": 1719,
"cdna_start": 651,
"cdna_end": null,
"cdna_length": 2127,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7",
"gene_hgnc_id": 11351,
"hgvs_c": "c.489T>C",
"hgvs_p": "p.Tyr163Tyr",
"transcript": "NM_001369604.1",
"protein_id": "NP_001356533.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 562,
"cds_start": 489,
"cds_end": null,
"cds_length": 1689,
"cdna_start": 529,
"cdna_end": null,
"cdna_length": 2656,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7",
"gene_hgnc_id": 11351,
"hgvs_c": "c.333T>C",
"hgvs_p": "p.Tyr111Tyr",
"transcript": "ENST00000490039.1",
"protein_id": "ENSP00000419516.1",
"transcript_support_level": 5,
"aa_start": 111,
"aa_end": null,
"aa_length": 560,
"cds_start": 333,
"cds_end": null,
"cds_length": 1684,
"cdna_start": 338,
"cdna_end": null,
"cdna_length": 1689,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7",
"gene_hgnc_id": 11351,
"hgvs_c": "c.489T>C",
"hgvs_p": "p.Tyr163Tyr",
"transcript": "ENST00000446490.5",
"protein_id": "ENSP00000402934.1",
"transcript_support_level": 5,
"aa_start": 163,
"aa_end": null,
"aa_length": 557,
"cds_start": 489,
"cds_end": null,
"cds_length": 1674,
"cdna_start": 509,
"cdna_end": null,
"cdna_length": 1694,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7",
"gene_hgnc_id": 11351,
"hgvs_c": "c.489T>C",
"hgvs_p": "p.Tyr163Tyr",
"transcript": "NM_018412.4",
"protein_id": "NP_060882.2",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 554,
"cds_start": 489,
"cds_end": null,
"cds_length": 1665,
"cdna_start": 529,
"cdna_end": null,
"cdna_length": 2024,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7",
"gene_hgnc_id": 11351,
"hgvs_c": "c.360T>C",
"hgvs_p": "p.Tyr120Tyr",
"transcript": "NM_001369599.1",
"protein_id": "NP_001356528.1",
"transcript_support_level": null,
"aa_start": 120,
"aa_end": null,
"aa_length": 534,
"cds_start": 360,
"cds_end": null,
"cds_length": 1605,
"cdna_start": 750,
"cdna_end": null,
"cdna_length": 2314,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7",
"gene_hgnc_id": 11351,
"hgvs_c": "c.351T>C",
"hgvs_p": "p.Tyr117Tyr",
"transcript": "NM_001369602.1",
"protein_id": "NP_001356531.1",
"transcript_support_level": null,
"aa_start": 117,
"aa_end": null,
"aa_length": 531,
"cds_start": 351,
"cds_end": null,
"cds_length": 1596,
"cdna_start": 441,
"cdna_end": null,
"cdna_length": 2005,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7",
"gene_hgnc_id": 11351,
"hgvs_c": "c.351T>C",
"hgvs_p": "p.Tyr117Tyr",
"transcript": "ENST00000432298.5",
"protein_id": "ENSP00000411118.1",
"transcript_support_level": 2,
"aa_start": 117,
"aa_end": null,
"aa_length": 531,
"cds_start": 351,
"cds_end": null,
"cds_length": 1596,
"cdna_start": 465,
"cdna_end": null,
"cdna_length": 1956,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7",
"gene_hgnc_id": 11351,
"hgvs_c": "c.339T>C",
"hgvs_p": "p.Tyr113Tyr",
"transcript": "NM_001369606.1",
"protein_id": "NP_001356535.1",
"transcript_support_level": null,
"aa_start": 113,
"aa_end": null,
"aa_length": 527,
"cds_start": 339,
"cds_end": null,
"cds_length": 1584,
"cdna_start": 953,
"cdna_end": null,
"cdna_length": 2517,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7",
"gene_hgnc_id": 11351,
"hgvs_c": "c.489T>C",
"hgvs_p": "p.Tyr163Tyr",
"transcript": "ENST00000393446.6",
"protein_id": "ENSP00000377092.2",
"transcript_support_level": 5,
"aa_start": 163,
"aa_end": null,
"aa_length": 523,
"cds_start": 489,
"cds_end": null,
"cds_length": 1572,
"cdna_start": 792,
"cdna_end": null,
"cdna_length": 2114,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7",
"gene_hgnc_id": 11351,
"hgvs_c": "c.360T>C",
"hgvs_p": "p.Tyr120Tyr",
"transcript": "NM_001369600.1",
"protein_id": "NP_001356529.1",
"transcript_support_level": null,
"aa_start": 120,
"aa_end": null,
"aa_length": 511,
"cds_start": 360,
"cds_end": null,
"cds_length": 1536,
"cdna_start": 750,
"cdna_end": null,
"cdna_length": 2245,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ST7",
"gene_hgnc_id": 11351,
"hgvs_c": "c.351T>C",
"hgvs_p": "p.Tyr117Tyr",
"transcript": "NM_001369603.1",
"protein_id": "NP_001356532.1",
"transcript_support_level": null,
"aa_start": 117,
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}