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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 7-120810570-CCTGGT-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=120810570&ref=CCTGGT&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "7",
      "pos": 120810570,
      "ref": "CCTGGT",
      "alt": "C",
      "effect": "splice_acceptor_variant,splice_region_variant,intron_variant",
      "transcript": "NM_012338.4",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "TSPAN12",
          "gene_hgnc_id": 21641,
          "hgvs_c": "c.361-5_361-1delACCAG",
          "hgvs_p": null,
          "transcript": "NM_012338.4",
          "protein_id": "NP_036470.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 305,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 918,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000222747.8",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_012338.4"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "TSPAN12",
          "gene_hgnc_id": 21641,
          "hgvs_c": "c.361-5_361-1delACCAG",
          "hgvs_p": null,
          "transcript": "ENST00000222747.8",
          "protein_id": "ENSP00000222747.3",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 305,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 918,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_012338.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000222747.8"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "TSPAN12",
          "gene_hgnc_id": 21641,
          "hgvs_c": "c.361-5_361-1delACCAG",
          "hgvs_p": null,
          "transcript": "ENST00000415871.5",
          "protein_id": "ENSP00000397699.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 305,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 918,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000415871.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "TSPAN12",
          "gene_hgnc_id": 21641,
          "hgvs_c": "c.361-5_361-1delACCAG",
          "hgvs_p": null,
          "transcript": "ENST00000854320.1",
          "protein_id": "ENSP00000524379.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 305,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 918,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000854320.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "TSPAN12",
          "gene_hgnc_id": 21641,
          "hgvs_c": "c.361-5_361-1delACCAG",
          "hgvs_p": null,
          "transcript": "ENST00000854325.1",
          "protein_id": "ENSP00000524384.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 305,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 918,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000854325.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": 4,
          "intron_rank_end": null,
          "gene_symbol": "TSPAN12",
          "gene_hgnc_id": 21641,
          "hgvs_c": "c.361-5_361-1delACCAG",
          "hgvs_p": null,
          "transcript": "ENST00000854326.1",
          "protein_id": "ENSP00000524385.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 305,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 918,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000854326.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "TSPAN12",
          "gene_hgnc_id": 21641,
          "hgvs_c": "c.361-5_361-1delACCAG",
          "hgvs_p": null,
          "transcript": "ENST00000968603.1",
          "protein_id": "ENSP00000638662.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 305,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 918,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000968603.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "TSPAN12",
          "gene_hgnc_id": 21641,
          "hgvs_c": "c.361-5_361-1delACCAG",
          "hgvs_p": null,
          "transcript": "ENST00000968604.1",
          "protein_id": "ENSP00000638663.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": 305,
          "cds_start": null,
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          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
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        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "TSPAN12",
          "gene_hgnc_id": 21641,
          "hgvs_c": "c.361-5_361-1delACCAG",
          "hgvs_p": null,
          "transcript": "ENST00000968602.1",
          "protein_id": "ENSP00000638661.1",
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          "aa_start": null,
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          "cds_start": null,
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          "cdna_start": null,
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          "mane_select": null,
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        {
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          "canonical": false,
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          "strand": false,
          "consequences": [
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          "exon_count": 8,
          "intron_rank": 5,
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          "gene_symbol": "TSPAN12",
          "gene_hgnc_id": 21641,
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          "cds_start": null,
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        {
          "aa_ref": null,
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          "canonical": false,
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          "strand": false,
          "consequences": [
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          ],
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          "exon_count": 7,
          "intron_rank": 4,
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          "gene_symbol": "TSPAN12",
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          "intron_rank": 4,
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          "gene_symbol": "TSPAN12",
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          "consequences": [
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            "splice_region_variant",
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          ],
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          "exon_count": 6,
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          "gene_symbol": "TSPAN12",
          "gene_hgnc_id": 21641,
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          "transcript": "ENST00000441017.5",
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            "splice_region_variant",
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          "gene_symbol": "TSPAN12",
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        },
        {
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            "splice_region_variant",
            "intron_variant"
          ],
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          "exon_count": 6,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "TSPAN12",
          "gene_hgnc_id": 21641,
          "hgvs_c": "n.*211-5_*211-1delACCAG",
          "hgvs_p": null,
          "transcript": "ENST00000450414.5",
          "protein_id": "ENSP00000397411.1",
          "transcript_support_level": 5,
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          "mane_select": null,
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          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000450414.5"
        }
      ],
      "gene_symbol": "TSPAN12",
      "gene_hgnc_id": 21641,
      "dbsnp": "rs794726655",
      "frequency_reference_population": null,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 0,
      "gnomad_exomes_af": null,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": null,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": null,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": null,
      "computational_prediction_selected": null,
      "computational_source_selected": null,
      "splice_score_selected": null,
      "splice_prediction_selected": null,
      "splice_source_selected": null,
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": null,
      "bayesdelnoaf_prediction": null,
      "phylop100way_score": 5.199,
      "phylop100way_prediction": "Uncertain_significance",
      "spliceai_max_score": null,
      "spliceai_max_prediction": null,
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 7,
      "acmg_classification": "Likely_pathogenic",
      "acmg_criteria": "PVS1_Strong,PM2,PP5",
      "acmg_by_gene": [
        {
          "score": 7,
          "benign_score": 0,
          "pathogenic_score": 7,
          "criteria": [
            "PVS1_Strong",
            "PM2",
            "PP5"
          ],
          "verdict": "Likely_pathogenic",
          "transcript": "NM_012338.4",
          "gene_symbol": "TSPAN12",
          "hgnc_id": 21641,
          "effects": [
            "splice_acceptor_variant",
            "splice_region_variant",
            "intron_variant"
          ],
          "inheritance_mode": "AD,SD",
          "hgvs_c": "c.361-5_361-1delACCAG",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "Exudative vitreoretinopathy 5",
      "clinvar_classification": "Pathogenic",
      "clinvar_review_status": "no assertion criteria provided",
      "clinvar_submissions_summary": "null",
      "phenotype_combined": "Exudative vitreoretinopathy 5",
      "pathogenicity_classification_combined": "Pathogenic",
      "custom_annotations": null
    }
  ],
  "message": null
}