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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 7-13919781-G-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=13919781&ref=G&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "7",
      "pos": 13919781,
      "ref": "G",
      "alt": "T",
      "effect": "intron_variant",
      "transcript": "ENST00000430479.6",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": 9,
          "intron_rank_end": null,
          "gene_symbol": "ETV1",
          "gene_hgnc_id": 3490,
          "hgvs_c": "c.803-8474C>A",
          "hgvs_p": null,
          "transcript": "NM_004956.5",
          "protein_id": "NP_004947.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 477,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1434,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 6459,
          "mane_select": "ENST00000430479.6",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": 9,
          "intron_rank_end": null,
          "gene_symbol": "ETV1",
          "gene_hgnc_id": 3490,
          "hgvs_c": "c.803-8474C>A",
          "hgvs_p": null,
          "transcript": "ENST00000430479.6",
          "protein_id": "ENSP00000405327.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 477,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1434,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 6459,
          "mane_select": "NM_004956.5",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": 7,
          "intron_rank_end": null,
          "gene_symbol": "ETV1",
          "gene_hgnc_id": 3490,
          "hgvs_c": "c.845-8474C>A",
          "hgvs_p": null,
          "transcript": "ENST00000405358.8",
          "protein_id": "ENSP00000384085.4",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 491,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1476,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4181,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": 8,
          "intron_rank_end": null,
          "gene_symbol": "ETV1",
          "gene_hgnc_id": 3490,
          "hgvs_c": "c.803-8474C>A",
          "hgvs_p": null,
          "transcript": "ENST00000405218.6",
          "protein_id": "ENSP00000385551.2",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 477,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1434,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3391,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": 7,
          "intron_rank_end": null,
          "gene_symbol": "ETV1",
          "gene_hgnc_id": 3490,
          "hgvs_c": "c.749-8474C>A",
          "hgvs_p": null,
          "transcript": "ENST00000403685.5",
          "protein_id": "ENSP00000385686.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 459,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1380,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1603,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": 8,
          "intron_rank_end": null,
          "gene_symbol": "ETV1",
          "gene_hgnc_id": 3490,
          "hgvs_c": "c.803-10081C>A",
          "hgvs_p": null,
          "transcript": "ENST00000405192.6",
          "protein_id": "ENSP00000385381.2",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 454,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1365,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4402,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "ETV1",
          "gene_hgnc_id": 3490,
          "hgvs_c": "c.683-8474C>A",
          "hgvs_p": null,
          "transcript": "ENST00000403527.6",
          "protein_id": "ENSP00000384138.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 437,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1314,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 6187,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": 4,
          "intron_rank_end": null,
          "gene_symbol": "ETV1",
          "gene_hgnc_id": 3490,
          "hgvs_c": "c.629-8474C>A",
          "hgvs_p": null,
          "transcript": "ENST00000438956.6",
          "protein_id": "ENSP00000393078.2",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 419,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1260,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3253,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": 9,
          "intron_rank_end": null,
          "gene_symbol": "ETV1",
          "gene_hgnc_id": 3490,
          "hgvs_c": "n.803-8474C>A",
          "hgvs_p": null,
          "transcript": "ENST00000443137.5",
          "protein_id": "ENSP00000413836.1",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 2050,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "ETV1",
          "gene_hgnc_id": 3490,
          "hgvs_c": "n.757-8474C>A",
          "hgvs_p": null,
          "transcript": "ENST00000472931.6",
          "protein_id": null,
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 1296,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
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          "exon_rank": null,
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          "exon_count": 6,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "ETV1",
          "gene_hgnc_id": 3490,
          "hgvs_c": "n.788-8474C>A",
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          "transcript": "ENST00000476720.6",
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          "transcript_support_level": 1,
          "aa_start": null,
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          "cds_start": -4,
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          "cdna_start": null,
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          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
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        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          "exon_count": 13,
          "intron_rank": 8,
          "intron_rank_end": null,
          "gene_symbol": "ETV1",
          "gene_hgnc_id": 3490,
          "hgvs_c": "c.803-8474C>A",
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          "transcript": "NM_001370555.1",
          "protein_id": "NP_001357484.1",
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          "canonical": false,
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          "exon_rank": null,
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          "intron_rank": 7,
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          "gene_symbol": "ETV1",
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          "hgvs_c": "c.755-8474C>A",
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          "transcript": "NM_001370556.1",
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          "cds_start": -4,
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          "cdna_start": null,
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        {
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          "gene_symbol": "ETV1",
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          "hgvs_c": "c.749-8474C>A",
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          "mane_select": null,
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        {
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          "gene_symbol": "ETV1",
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          "gene_symbol": "ETV1",
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          "hgvs_c": "c.803-10081C>A",
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        {
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          "gene_symbol": "ETV1",
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          "gene_symbol": "ETV1",
          "gene_hgnc_id": 3490,
          "hgvs_c": "c.494-8474C>A",
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          "transcript": "ENST00000443608.6",
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      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
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      "custom_annotations": null
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  "message": null
}