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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 7-141555469-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=141555469&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "7",
"pos": 141555469,
"ref": "G",
"alt": "A",
"effect": "start_lost",
"transcript": "NM_018238.4",
"consequences": [
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "NM_018238.4",
"protein_id": "NP_060708.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 422,
"cds_start": 3,
"cds_end": null,
"cds_length": 1269,
"cdna_start": 42,
"cdna_end": null,
"cdna_length": 3628,
"mane_select": "ENST00000649286.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_018238.4"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000649286.2",
"protein_id": "ENSP00000497280.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 422,
"cds_start": 3,
"cds_end": null,
"cds_length": 1269,
"cdna_start": 42,
"cdna_end": null,
"cdna_length": 3628,
"mane_select": "NM_018238.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000649286.2"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000492693.5",
"protein_id": "ENSP00000418789.1",
"transcript_support_level": 1,
"aa_start": 1,
"aa_end": null,
"aa_length": 65,
"cds_start": 3,
"cds_end": null,
"cds_length": 198,
"cdna_start": 17,
"cdna_end": null,
"cdna_length": 1046,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000492693.5"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000912229.1",
"protein_id": "ENSP00000582288.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 454,
"cds_start": 3,
"cds_end": null,
"cds_length": 1365,
"cdna_start": 1479,
"cdna_end": null,
"cdna_length": 4179,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912229.1"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000909108.1",
"protein_id": "ENSP00000579167.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 430,
"cds_start": 3,
"cds_end": null,
"cds_length": 1293,
"cdna_start": 17,
"cdna_end": null,
"cdna_length": 2282,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909108.1"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000648068.1",
"protein_id": "ENSP00000498112.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 422,
"cds_start": 3,
"cds_end": null,
"cds_length": 1269,
"cdna_start": 83,
"cdna_end": null,
"cdna_length": 2256,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000648068.1"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000650547.1",
"protein_id": "ENSP00000496789.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 422,
"cds_start": 3,
"cds_end": null,
"cds_length": 1269,
"cdna_start": 72,
"cdna_end": null,
"cdna_length": 2472,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000650547.1"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000909102.1",
"protein_id": "ENSP00000579161.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 422,
"cds_start": 3,
"cds_end": null,
"cds_length": 1269,
"cdna_start": 234,
"cdna_end": null,
"cdna_length": 2579,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909102.1"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000909104.1",
"protein_id": "ENSP00000579163.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 422,
"cds_start": 3,
"cds_end": null,
"cds_length": 1269,
"cdna_start": 31,
"cdna_end": null,
"cdna_length": 2284,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909104.1"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000909105.1",
"protein_id": "ENSP00000579164.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 422,
"cds_start": 3,
"cds_end": null,
"cds_length": 1269,
"cdna_start": 147,
"cdna_end": null,
"cdna_length": 2391,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909105.1"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000909106.1",
"protein_id": "ENSP00000579165.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 422,
"cds_start": 3,
"cds_end": null,
"cds_length": 1269,
"cdna_start": 516,
"cdna_end": null,
"cdna_length": 2857,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909106.1"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000912226.1",
"protein_id": "ENSP00000582285.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 422,
"cds_start": 3,
"cds_end": null,
"cds_length": 1269,
"cdna_start": 52,
"cdna_end": null,
"cdna_length": 2537,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912226.1"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000912227.1",
"protein_id": "ENSP00000582286.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 422,
"cds_start": 3,
"cds_end": null,
"cds_length": 1269,
"cdna_start": 50,
"cdna_end": null,
"cdna_length": 2290,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912227.1"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000912228.1",
"protein_id": "ENSP00000582287.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 422,
"cds_start": 3,
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"cds_length": 1269,
"cdna_start": 741,
"cdna_end": null,
"cdna_length": 3346,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912228.1"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000962104.1",
"protein_id": "ENSP00000632163.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 422,
"cds_start": 3,
"cds_end": null,
"cds_length": 1269,
"cdna_start": 74,
"cdna_end": null,
"cdna_length": 2832,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962104.1"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000962105.1",
"protein_id": "ENSP00000632164.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 422,
"cds_start": 3,
"cds_end": null,
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"cdna_start": 144,
"cdna_end": null,
"cdna_length": 2628,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962105.1"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000962106.1",
"protein_id": "ENSP00000632165.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 422,
"cds_start": 3,
"cds_end": null,
"cds_length": 1269,
"cdna_start": 130,
"cdna_end": null,
"cdna_length": 2372,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962106.1"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000909101.1",
"protein_id": "ENSP00000579160.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 421,
"cds_start": 3,
"cds_end": null,
"cds_length": 1266,
"cdna_start": 42,
"cdna_end": null,
"cdna_length": 2526,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909101.1"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000909107.1",
"protein_id": "ENSP00000579166.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 391,
"cds_start": 3,
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"cds_length": 1176,
"cdna_start": 17,
"cdna_end": null,
"cdna_length": 2409,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909107.1"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000909103.1",
"protein_id": "ENSP00000579162.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 356,
"cds_start": 3,
"cds_end": null,
"cds_length": 1071,
"cdna_start": 51,
"cdna_end": null,
"cdna_length": 2099,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909103.1"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "NM_001364948.3",
"protein_id": "NP_001351877.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 350,
"cds_start": 3,
"cds_end": null,
"cds_length": 1053,
"cdna_start": 42,
"cdna_end": null,
"cdna_length": 1216,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001364948.3"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGK",
"gene_hgnc_id": 21869,
"hgvs_c": "c.3G>A",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000650006.1",
"protein_id": "ENSP00000497457.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 350,
"cds_start": 3,
"cds_end": null,
"cds_length": 1053,
"cdna_start": 31,
"cdna_end": null,
"cdna_length": 1201,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000650006.1"
},
{
"aa_ref": "M",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
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}