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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 7-149721467-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=149721467&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "7",
"pos": 149721467,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "ENST00000496259.6",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRABD3",
"gene_hgnc_id": 22228,
"hgvs_c": "c.500C>G",
"hgvs_p": "p.Thr167Arg",
"transcript": "NM_001290187.2",
"protein_id": "NP_001277116.1",
"transcript_support_level": null,
"aa_start": 167,
"aa_end": null,
"aa_length": 1064,
"cds_start": 500,
"cds_end": null,
"cds_length": 3195,
"cdna_start": 604,
"cdna_end": null,
"cdna_length": 3827,
"mane_select": "ENST00000496259.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRBA1",
"gene_hgnc_id": 22228,
"hgvs_c": "c.500C>G",
"hgvs_p": "p.Thr167Arg",
"transcript": "ENST00000496259.6",
"protein_id": "ENSP00000418647.3",
"transcript_support_level": 1,
"aa_start": 167,
"aa_end": null,
"aa_length": 1064,
"cds_start": 500,
"cds_end": null,
"cds_length": 3195,
"cdna_start": 604,
"cdna_end": null,
"cdna_length": 3827,
"mane_select": "NM_001290187.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRBA1",
"gene_hgnc_id": 22228,
"hgvs_c": "c.398C>G",
"hgvs_p": "p.Thr133Arg",
"transcript": "ENST00000319551.12",
"protein_id": "ENSP00000317165.9",
"transcript_support_level": 1,
"aa_start": 133,
"aa_end": null,
"aa_length": 1030,
"cds_start": 398,
"cds_end": null,
"cds_length": 3093,
"cdna_start": 797,
"cdna_end": null,
"cdna_length": 4020,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRBA1",
"gene_hgnc_id": 22228,
"hgvs_c": "n.266C>G",
"hgvs_p": null,
"transcript": "ENST00000621069.1",
"protein_id": "ENSP00000479341.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3449,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRABD3",
"gene_hgnc_id": 22228,
"hgvs_c": "c.566C>G",
"hgvs_p": "p.Thr189Arg",
"transcript": "NM_001394491.1",
"protein_id": "NP_001381420.1",
"transcript_support_level": null,
"aa_start": 189,
"aa_end": null,
"aa_length": 1086,
"cds_start": 566,
"cds_end": null,
"cds_length": 3261,
"cdna_start": 670,
"cdna_end": null,
"cdna_length": 3893,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRABD3",
"gene_hgnc_id": 22228,
"hgvs_c": "c.500C>G",
"hgvs_p": "p.Thr167Arg",
"transcript": "NM_001394478.1",
"protein_id": "NP_001381407.1",
"transcript_support_level": null,
"aa_start": 167,
"aa_end": null,
"aa_length": 1080,
"cds_start": 500,
"cds_end": null,
"cds_length": 3243,
"cdna_start": 604,
"cdna_end": null,
"cdna_length": 3875,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRABD3",
"gene_hgnc_id": 22228,
"hgvs_c": "c.503C>G",
"hgvs_p": "p.Thr168Arg",
"transcript": "NM_001394479.1",
"protein_id": "NP_001381408.1",
"transcript_support_level": null,
"aa_start": 168,
"aa_end": null,
"aa_length": 1065,
"cds_start": 503,
"cds_end": null,
"cds_length": 3198,
"cdna_start": 607,
"cdna_end": null,
"cdna_length": 3830,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRABD3",
"gene_hgnc_id": 22228,
"hgvs_c": "c.458C>G",
"hgvs_p": "p.Thr153Arg",
"transcript": "NM_001394480.1",
"protein_id": "NP_001381409.1",
"transcript_support_level": null,
"aa_start": 153,
"aa_end": null,
"aa_length": 1050,
"cds_start": 458,
"cds_end": null,
"cds_length": 3153,
"cdna_start": 562,
"cdna_end": null,
"cdna_length": 3785,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRABD3",
"gene_hgnc_id": 22228,
"hgvs_c": "c.455C>G",
"hgvs_p": "p.Thr152Arg",
"transcript": "NM_001394481.1",
"protein_id": "NP_001381410.1",
"transcript_support_level": null,
"aa_start": 152,
"aa_end": null,
"aa_length": 1049,
"cds_start": 455,
"cds_end": null,
"cds_length": 3150,
"cdna_start": 559,
"cdna_end": null,
"cdna_length": 3782,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRABD3",
"gene_hgnc_id": 22228,
"hgvs_c": "c.398C>G",
"hgvs_p": "p.Thr133Arg",
"transcript": "NM_032534.4",
"protein_id": "NP_115923.2",
"transcript_support_level": null,
"aa_start": 133,
"aa_end": null,
"aa_length": 1030,
"cds_start": 398,
"cds_end": null,
"cds_length": 3093,
"cdna_start": 903,
"cdna_end": null,
"cdna_length": 4126,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRABD3",
"gene_hgnc_id": 22228,
"hgvs_c": "c.395C>G",
"hgvs_p": "p.Thr132Arg",
"transcript": "NM_001394482.1",
"protein_id": "NP_001381411.1",
"transcript_support_level": null,
"aa_start": 132,
"aa_end": null,
"aa_length": 1029,
"cds_start": 395,
"cds_end": null,
"cds_length": 3090,
"cdna_start": 617,
"cdna_end": null,
"cdna_length": 3840,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRABD3",
"gene_hgnc_id": 22228,
"hgvs_c": "c.395C>G",
"hgvs_p": "p.Thr132Arg",
"transcript": "NM_001394483.1",
"protein_id": "NP_001381412.1",
"transcript_support_level": null,
"aa_start": 132,
"aa_end": null,
"aa_length": 1029,
"cds_start": 395,
"cds_end": null,
"cds_length": 3090,
"cdna_start": 728,
"cdna_end": null,
"cdna_length": 3951,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRABD3",
"gene_hgnc_id": 22228,
"hgvs_c": "c.500C>G",
"hgvs_p": "p.Thr167Arg",
"transcript": "NM_001394484.1",
"protein_id": "NP_001381413.1",
"transcript_support_level": null,
"aa_start": 167,
"aa_end": null,
"aa_length": 1003,
"cds_start": 500,
"cds_end": null,
"cds_length": 3012,
"cdna_start": 604,
"cdna_end": null,
"cdna_length": 3644,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRABD3",
"gene_hgnc_id": 22228,
"hgvs_c": "c.398C>G",
"hgvs_p": "p.Thr133Arg",
"transcript": "NM_001394485.1",
"protein_id": "NP_001381414.1",
"transcript_support_level": null,
"aa_start": 133,
"aa_end": null,
"aa_length": 969,
"cds_start": 398,
"cds_end": null,
"cds_length": 2910,
"cdna_start": 620,
"cdna_end": null,
"cdna_length": 3660,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRBA1",
"gene_hgnc_id": 22228,
"hgvs_c": "c.398C>G",
"hgvs_p": "p.Thr133Arg",
"transcript": "ENST00000485033.6",
"protein_id": "ENSP00000420112.2",
"transcript_support_level": 5,
"aa_start": 133,
"aa_end": null,
"aa_length": 969,
"cds_start": 398,
"cds_end": null,
"cds_length": 2910,
"cdna_start": 398,
"cdna_end": null,
"cdna_length": 3434,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRABD3",
"gene_hgnc_id": 22228,
"hgvs_c": "c.503C>G",
"hgvs_p": "p.Thr168Arg",
"transcript": "NM_001394486.1",
"protein_id": "NP_001381415.1",
"transcript_support_level": null,
"aa_start": 168,
"aa_end": null,
"aa_length": 760,
"cds_start": 503,
"cds_end": null,
"cds_length": 2283,
"cdna_start": 607,
"cdna_end": null,
"cdna_length": 3807,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRABD3",
"gene_hgnc_id": 22228,
"hgvs_c": "c.500C>G",
"hgvs_p": "p.Thr167Arg",
"transcript": "NM_001394487.1",
"protein_id": "NP_001381416.1",
"transcript_support_level": null,
"aa_start": 167,
"aa_end": null,
"aa_length": 759,
"cds_start": 500,
"cds_end": null,
"cds_length": 2280,
"cdna_start": 604,
"cdna_end": null,
"cdna_length": 3804,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRABD3",
"gene_hgnc_id": 22228,
"hgvs_c": "c.350C>G",
"hgvs_p": "p.Thr117Arg",
"transcript": "NM_001394488.1",
"protein_id": "NP_001381417.1",
"transcript_support_level": null,
"aa_start": 117,
"aa_end": null,
"aa_length": 709,
"cds_start": 350,
"cds_end": null,
"cds_length": 2130,
"cdna_start": 572,
"cdna_end": null,
"cdna_length": 3772,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRABD3",
"gene_hgnc_id": 22228,
"hgvs_c": "c.500C>G",
"hgvs_p": "p.Thr167Arg",
"transcript": "NM_001394489.1",
"protein_id": "NP_001381418.1",
"transcript_support_level": null,
"aa_start": 167,
"aa_end": null,
"aa_length": 698,
"cds_start": 500,
"cds_end": null,
"cds_length": 2097,
"cdna_start": 604,
"cdna_end": null,
"cdna_length": 3621,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRABD3",
"gene_hgnc_id": 22228,
"hgvs_c": "c.455C>G",
"hgvs_p": "p.Thr152Arg",
"transcript": "NM_001394490.1",
"protein_id": "NP_001381419.1",
"transcript_support_level": null,
"aa_start": 152,
"aa_end": null,
"aa_length": 683,
"cds_start": 455,
"cds_end": null,
"cds_length": 2052,
"cdna_start": 559,
"cdna_end": null,
"cdna_length": 3576,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRABD3",
"gene_hgnc_id": 22228,
"hgvs_c": "c.398C>G",
"hgvs_p": "p.Thr133Arg",
"transcript": "NM_001394492.1",
"protein_id": "NP_001381421.1",
"transcript_support_level": null,
"aa_start": 133,
"aa_end": null,
"aa_length": 664,
"cds_start": 398,
"cds_end": null,
"cds_length": 1995,
"cdna_start": 620,
"cdna_end": null,
"cdna_length": 3637,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRABD3",
"gene_hgnc_id": 22228,
"hgvs_c": "c.455C>G",
"hgvs_p": "p.Thr152Arg",
"transcript": "NM_001394493.1",
"protein_id": "NP_001381422.1",
"transcript_support_level": null,
"aa_start": 152,
"aa_end": null,
"aa_length": 276,
"cds_start": 455,
"cds_end": null,
"cds_length": 831,
"cdna_start": 559,
"cdna_end": null,
"cdna_length": 1132,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KRBA1",
"gene_hgnc_id": 22228,
"hgvs_c": "c.125C>G",
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