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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 7-149765108-T-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=149765108&ref=T&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "7",
      "pos": 149765108,
      "ref": "T",
      "alt": "C",
      "effect": "missense_variant",
      "transcript": "NM_207336.3",
      "consequences": [
        {
          "aa_ref": "D",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF467",
          "gene_hgnc_id": 23154,
          "hgvs_c": "c.1394A>G",
          "hgvs_p": "p.Asp465Gly",
          "transcript": "NM_207336.3",
          "protein_id": "NP_997219.1",
          "transcript_support_level": null,
          "aa_start": 465,
          "aa_end": null,
          "aa_length": 595,
          "cds_start": 1394,
          "cds_end": null,
          "cds_length": 1788,
          "cdna_start": 1917,
          "cdna_end": null,
          "cdna_length": 2843,
          "mane_select": "ENST00000302017.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_207336.3"
        },
        {
          "aa_ref": "D",
          "aa_alt": "G",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF467",
          "gene_hgnc_id": 23154,
          "hgvs_c": "c.1394A>G",
          "hgvs_p": "p.Asp465Gly",
          "transcript": "ENST00000302017.4",
          "protein_id": "ENSP00000304769.3",
          "transcript_support_level": 1,
          "aa_start": 465,
          "aa_end": null,
          "aa_length": 595,
          "cds_start": 1394,
          "cds_end": null,
          "cds_length": 1788,
          "cdna_start": 1917,
          "cdna_end": null,
          "cdna_length": 2843,
          "mane_select": "NM_207336.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000302017.4"
        },
        {
          "aa_ref": "D",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF467",
          "gene_hgnc_id": 23154,
          "hgvs_c": "c.1514A>G",
          "hgvs_p": "p.Asp505Gly",
          "transcript": "ENST00000882874.1",
          "protein_id": "ENSP00000552933.1",
          "transcript_support_level": null,
          "aa_start": 505,
          "aa_end": null,
          "aa_length": 635,
          "cds_start": 1514,
          "cds_end": null,
          "cds_length": 1908,
          "cdna_start": 2021,
          "cdna_end": null,
          "cdna_length": 2761,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000882874.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF467",
          "gene_hgnc_id": 23154,
          "hgvs_c": "c.1394A>G",
          "hgvs_p": "p.Asp465Gly",
          "transcript": "ENST00000882861.1",
          "protein_id": "ENSP00000552920.1",
          "transcript_support_level": null,
          "aa_start": 465,
          "aa_end": null,
          "aa_length": 595,
          "cds_start": 1394,
          "cds_end": null,
          "cds_length": 1788,
          "cdna_start": 1720,
          "cdna_end": null,
          "cdna_length": 2650,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000882861.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF467",
          "gene_hgnc_id": 23154,
          "hgvs_c": "c.1394A>G",
          "hgvs_p": "p.Asp465Gly",
          "transcript": "ENST00000882862.1",
          "protein_id": "ENSP00000552921.1",
          "transcript_support_level": null,
          "aa_start": 465,
          "aa_end": null,
          "aa_length": 595,
          "cds_start": 1394,
          "cds_end": null,
          "cds_length": 1788,
          "cdna_start": 1973,
          "cdna_end": null,
          "cdna_length": 2896,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000882862.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF467",
          "gene_hgnc_id": 23154,
          "hgvs_c": "c.1394A>G",
          "hgvs_p": "p.Asp465Gly",
          "transcript": "ENST00000882863.1",
          "protein_id": "ENSP00000552922.1",
          "transcript_support_level": null,
          "aa_start": 465,
          "aa_end": null,
          "aa_length": 595,
          "cds_start": 1394,
          "cds_end": null,
          "cds_length": 1788,
          "cdna_start": 2081,
          "cdna_end": null,
          "cdna_length": 3002,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000882863.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF467",
          "gene_hgnc_id": 23154,
          "hgvs_c": "c.1394A>G",
          "hgvs_p": "p.Asp465Gly",
          "transcript": "ENST00000882864.1",
          "protein_id": "ENSP00000552923.1",
          "transcript_support_level": null,
          "aa_start": 465,
          "aa_end": null,
          "aa_length": 595,
          "cds_start": 1394,
          "cds_end": null,
          "cds_length": 1788,
          "cdna_start": 1678,
          "cdna_end": null,
          "cdna_length": 2604,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000882864.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF467",
          "gene_hgnc_id": 23154,
          "hgvs_c": "c.1394A>G",
          "hgvs_p": "p.Asp465Gly",
          "transcript": "ENST00000882865.1",
          "protein_id": "ENSP00000552924.1",
          "transcript_support_level": null,
          "aa_start": 465,
          "aa_end": null,
          "aa_length": 595,
          "cds_start": 1394,
          "cds_end": null,
          "cds_length": 1788,
          "cdna_start": 1893,
          "cdna_end": null,
          "cdna_length": 2816,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000882865.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF467",
          "gene_hgnc_id": 23154,
          "hgvs_c": "c.1394A>G",
          "hgvs_p": "p.Asp465Gly",
          "transcript": "ENST00000882866.1",
          "protein_id": "ENSP00000552925.1",
          "transcript_support_level": null,
          "aa_start": 465,
          "aa_end": null,
          "aa_length": 595,
          "cds_start": 1394,
          "cds_end": null,
          "cds_length": 1788,
          "cdna_start": 3077,
          "cdna_end": null,
          "cdna_length": 4003,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000882866.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF467",
          "gene_hgnc_id": 23154,
          "hgvs_c": "c.1394A>G",
          "hgvs_p": "p.Asp465Gly",
          "transcript": "ENST00000882868.1",
          "protein_id": "ENSP00000552927.1",
          "transcript_support_level": null,
          "aa_start": 465,
          "aa_end": null,
          "aa_length": 595,
          "cds_start": 1394,
          "cds_end": null,
          "cds_length": 1788,
          "cdna_start": 2030,
          "cdna_end": null,
          "cdna_length": 2775,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000882868.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF467",
          "gene_hgnc_id": 23154,
          "hgvs_c": "c.1394A>G",
          "hgvs_p": "p.Asp465Gly",
          "transcript": "ENST00000882869.1",
          "protein_id": "ENSP00000552928.1",
          "transcript_support_level": null,
          "aa_start": 465,
          "aa_end": null,
          "aa_length": 595,
          "cds_start": 1394,
          "cds_end": null,
          "cds_length": 1788,
          "cdna_start": 2502,
          "cdna_end": null,
          "cdna_length": 3425,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000882869.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
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          "exon_count": 5,
          "intron_rank": null,
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          "gene_symbol": "ZNF467",
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          "hgvs_c": "c.1394A>G",
          "hgvs_p": "p.Asp465Gly",
          "transcript": "ENST00000882871.1",
          "protein_id": "ENSP00000552930.1",
          "transcript_support_level": null,
          "aa_start": 465,
          "aa_end": null,
          "aa_length": 595,
          "cds_start": 1394,
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          "cds_length": 1788,
          "cdna_start": 1996,
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          "cdna_length": 2929,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "D",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
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          "gene_symbol": "ZNF467",
          "gene_hgnc_id": 23154,
          "hgvs_c": "c.1394A>G",
          "hgvs_p": "p.Asp465Gly",
          "transcript": "ENST00000882873.1",
          "protein_id": "ENSP00000552932.1",
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          "aa_start": 465,
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          "aa_length": 595,
          "cds_start": 1394,
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          "cdna_start": 1980,
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          "cdna_length": 2718,
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          "biotype": "protein_coding",
          "feature": "ENST00000882873.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF467",
          "gene_hgnc_id": 23154,
          "hgvs_c": "c.1394A>G",
          "hgvs_p": "p.Asp465Gly",
          "transcript": "ENST00000882875.1",
          "protein_id": "ENSP00000552934.1",
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          "aa_start": 465,
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          "aa_length": 595,
          "cds_start": 1394,
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        {
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          "intron_rank": null,
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          "gene_symbol": "ZNF467",
          "gene_hgnc_id": 23154,
          "hgvs_c": "c.1394A>G",
          "hgvs_p": "p.Asp465Gly",
          "transcript": "ENST00000882877.1",
          "protein_id": "ENSP00000552936.1",
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          "cds_start": 1394,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000882877.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
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          "gene_symbol": "ZNF467",
          "gene_hgnc_id": 23154,
          "hgvs_c": "c.1394A>G",
          "hgvs_p": "p.Asp465Gly",
          "transcript": "ENST00000882878.1",
          "protein_id": "ENSP00000552937.1",
          "transcript_support_level": null,
          "aa_start": 465,
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          "cds_start": 1394,
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          "cdna_length": 2399,
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          "biotype": "protein_coding",
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        {
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          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 6,
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          "exon_count": 6,
          "intron_rank": null,
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          "gene_symbol": "ZNF467",
          "gene_hgnc_id": 23154,
          "hgvs_c": "c.1394A>G",
          "hgvs_p": "p.Asp465Gly",
          "transcript": "ENST00000882879.1",
          "protein_id": "ENSP00000552938.1",
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        {
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          ],
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          "gene_symbol": "ZNF467",
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          "hgvs_c": "c.1394A>G",
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          "transcript": "ENST00000882880.1",
          "protein_id": "ENSP00000552939.1",
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        {
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          "exon_count": 6,
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          "gene_symbol": "ZNF467",
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          "hgvs_c": "c.1394A>G",
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          "transcript": "ENST00000882881.1",
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          "cdna_length": 2602,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000882881.1"
        },
        {
          "aa_ref": "D",
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          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF467",
          "gene_hgnc_id": 23154,
          "hgvs_c": "c.1394A>G",
          "hgvs_p": "p.Asp465Gly",
          "transcript": "ENST00000882882.1",
          "protein_id": "ENSP00000552941.1",
          "transcript_support_level": null,
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          "cds_start": 1394,
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          "protein_id": "XP_047275893.1",
          "transcript_support_level": null,
          "aa_start": 428,
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          "aa_length": 558,
          "cds_start": 1283,
          "cds_end": null,
          "cds_length": 1677,
          "cdna_start": 1390,
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          "cdna_length": 2316,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "XM_047419937.1"
        },
        {
          "aa_ref": "D",
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          "protein_coding": true,
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            "missense_variant"
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          "exon_count": 3,
          "intron_rank": null,
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          "gene_symbol": "ZNF467",
          "gene_hgnc_id": 23154,
          "hgvs_c": "c.1166A>G",
          "hgvs_p": "p.Asp389Gly",
          "transcript": "XM_017011799.3",
          "protein_id": "XP_016867288.2",
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          "aa_start": 389,
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          "cds_length": 1560,
          "cdna_start": 1689,
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          "cdna_length": 2615,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "XM_017011799.3"
        },
        {
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          "canonical": false,
          "protein_coding": true,
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          "consequences": [
            "intron_variant"
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          "exon_rank": null,
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          "exon_count": 5,
          "intron_rank": 4,
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          "gene_symbol": "ZNF467",
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          "hgvs_c": "c.263-430A>G",
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          "transcript": "NM_001329856.2",
          "protein_id": "NP_001316785.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": 146,
          "cds_start": null,
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          "cds_length": 441,
          "cdna_start": null,
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          "cdna_length": 1282,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "NM_001329856.2"
        },
        {
          "aa_ref": null,
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          "protein_coding": true,
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            "intron_variant"
          ],
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          "exon_count": 5,
          "intron_rank": 4,
          "intron_rank_end": null,
          "gene_symbol": "ZNF467",
          "gene_hgnc_id": 23154,
          "hgvs_c": "c.263-430A>G",
          "hgvs_p": null,
          "transcript": "ENST00000484747.5",
          "protein_id": "ENSP00000418011.1",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 146,
          "cds_start": null,
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          "cds_length": 441,
          "cdna_start": null,
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          "cdna_length": 913,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000484747.5"
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      ],
      "gene_symbol": "ZNF467",
      "gene_hgnc_id": 23154,
      "dbsnp": "rs2117386386",
      "frequency_reference_population": 0.0000020409857,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 3,
      "gnomad_exomes_af": 0.00000151763,
      "gnomad_genomes_af": 0.0000065773,
      "gnomad_exomes_ac": 2,
      "gnomad_genomes_ac": 1,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.04256632924079895,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.121,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.0911,
      "alphamissense_prediction": "Benign",
      "bayesdelnoaf_score": -0.61,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 0.919,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -4,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "PM2,BP4_Strong,BP6_Moderate",
      "acmg_by_gene": [
        {
          "score": -4,
          "benign_score": 6,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Strong",
            "BP6_Moderate"
          ],
          "verdict": "Likely_benign",
          "transcript": "NM_207336.3",
          "gene_symbol": "ZNF467",
          "hgnc_id": 23154,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.1394A>G",
          "hgvs_p": "p.Asp465Gly"
        }
      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Likely benign",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "LB:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Likely benign",
      "custom_annotations": null
    }
  ],
  "message": null
}
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