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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 7-151376796-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=151376796&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "7",
"pos": 151376796,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_001243351.2",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1654C>T",
"hgvs_p": "p.Pro552Ser",
"transcript": "NM_001243351.2",
"protein_id": "NP_001230280.2",
"transcript_support_level": null,
"aa_start": 552,
"aa_end": null,
"aa_length": 615,
"cds_start": 1654,
"cds_end": null,
"cds_length": 1848,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000568733.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001243351.2"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1654C>T",
"hgvs_p": "p.Pro552Ser",
"transcript": "ENST00000568733.6",
"protein_id": "ENSP00000454264.2",
"transcript_support_level": 1,
"aa_start": 552,
"aa_end": null,
"aa_length": 615,
"cds_start": 1654,
"cds_end": null,
"cds_length": 1848,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001243351.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000568733.6"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1612C>T",
"hgvs_p": "p.Pro538Ser",
"transcript": "ENST00000413040.7",
"protein_id": "ENSP00000398644.3",
"transcript_support_level": 1,
"aa_start": 538,
"aa_end": null,
"aa_length": 601,
"cds_start": 1612,
"cds_end": null,
"cds_length": 1806,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000413040.7"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1708C>T",
"hgvs_p": "p.Pro570Ser",
"transcript": "ENST00000866417.1",
"protein_id": "ENSP00000536476.1",
"transcript_support_level": null,
"aa_start": 570,
"aa_end": null,
"aa_length": 633,
"cds_start": 1708,
"cds_end": null,
"cds_length": 1902,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866417.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1675C>T",
"hgvs_p": "p.Pro559Ser",
"transcript": "ENST00000959562.1",
"protein_id": "ENSP00000629621.1",
"transcript_support_level": null,
"aa_start": 559,
"aa_end": null,
"aa_length": 622,
"cds_start": 1675,
"cds_end": null,
"cds_length": 1869,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000959562.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1669C>T",
"hgvs_p": "p.Pro557Ser",
"transcript": "ENST00000866412.1",
"protein_id": "ENSP00000536471.1",
"transcript_support_level": null,
"aa_start": 557,
"aa_end": null,
"aa_length": 620,
"cds_start": 1669,
"cds_end": null,
"cds_length": 1863,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866412.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1669C>T",
"hgvs_p": "p.Pro557Ser",
"transcript": "ENST00000866415.1",
"protein_id": "ENSP00000536474.1",
"transcript_support_level": null,
"aa_start": 557,
"aa_end": null,
"aa_length": 620,
"cds_start": 1669,
"cds_end": null,
"cds_length": 1863,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866415.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1654C>T",
"hgvs_p": "p.Pro552Ser",
"transcript": "NM_001363529.2",
"protein_id": "NP_001350458.1",
"transcript_support_level": null,
"aa_start": 552,
"aa_end": null,
"aa_length": 615,
"cds_start": 1654,
"cds_end": null,
"cds_length": 1848,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001363529.2"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1654C>T",
"hgvs_p": "p.Pro552Ser",
"transcript": "ENST00000470229.6",
"protein_id": "ENSP00000418234.2",
"transcript_support_level": 2,
"aa_start": 552,
"aa_end": null,
"aa_length": 615,
"cds_start": 1654,
"cds_end": null,
"cds_length": 1848,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000470229.6"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1651C>T",
"hgvs_p": "p.Pro551Ser",
"transcript": "ENST00000866406.1",
"protein_id": "ENSP00000536465.1",
"transcript_support_level": null,
"aa_start": 551,
"aa_end": null,
"aa_length": 614,
"cds_start": 1651,
"cds_end": null,
"cds_length": 1845,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866406.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1636C>T",
"hgvs_p": "p.Pro546Ser",
"transcript": "ENST00000914412.1",
"protein_id": "ENSP00000584471.1",
"transcript_support_level": null,
"aa_start": 546,
"aa_end": null,
"aa_length": 609,
"cds_start": 1636,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000914412.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1633C>T",
"hgvs_p": "p.Pro545Ser",
"transcript": "ENST00000914410.1",
"protein_id": "ENSP00000584469.1",
"transcript_support_level": null,
"aa_start": 545,
"aa_end": null,
"aa_length": 608,
"cds_start": 1633,
"cds_end": null,
"cds_length": 1827,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000914410.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1627C>T",
"hgvs_p": "p.Pro543Ser",
"transcript": "ENST00000866402.1",
"protein_id": "ENSP00000536461.1",
"transcript_support_level": null,
"aa_start": 543,
"aa_end": null,
"aa_length": 606,
"cds_start": 1627,
"cds_end": null,
"cds_length": 1821,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866402.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1627C>T",
"hgvs_p": "p.Pro543Ser",
"transcript": "ENST00000866408.1",
"protein_id": "ENSP00000536467.1",
"transcript_support_level": null,
"aa_start": 543,
"aa_end": null,
"aa_length": 606,
"cds_start": 1627,
"cds_end": null,
"cds_length": 1821,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866408.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1612C>T",
"hgvs_p": "p.Pro538Ser",
"transcript": "NM_001385353.1",
"protein_id": "NP_001372282.1",
"transcript_support_level": null,
"aa_start": 538,
"aa_end": null,
"aa_length": 601,
"cds_start": 1612,
"cds_end": null,
"cds_length": 1806,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001385353.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1612C>T",
"hgvs_p": "p.Pro538Ser",
"transcript": "NM_016118.5",
"protein_id": "NP_057202.4",
"transcript_support_level": null,
"aa_start": 538,
"aa_end": null,
"aa_length": 601,
"cds_start": 1612,
"cds_end": null,
"cds_length": 1806,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_016118.5"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1612C>T",
"hgvs_p": "p.Pro538Ser",
"transcript": "ENST00000866401.1",
"protein_id": "ENSP00000536460.1",
"transcript_support_level": null,
"aa_start": 538,
"aa_end": null,
"aa_length": 601,
"cds_start": 1612,
"cds_end": null,
"cds_length": 1806,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866401.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1612C>T",
"hgvs_p": "p.Pro538Ser",
"transcript": "ENST00000866411.1",
"protein_id": "ENSP00000536470.1",
"transcript_support_level": null,
"aa_start": 538,
"aa_end": null,
"aa_length": 601,
"cds_start": 1612,
"cds_end": null,
"cds_length": 1806,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866411.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1612C>T",
"hgvs_p": "p.Pro538Ser",
"transcript": "ENST00000959560.1",
"protein_id": "ENSP00000629619.1",
"transcript_support_level": null,
"aa_start": 538,
"aa_end": null,
"aa_length": 601,
"cds_start": 1612,
"cds_end": null,
"cds_length": 1806,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000959560.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1609C>T",
"hgvs_p": "p.Pro537Ser",
"transcript": "NM_001385354.1",
"protein_id": "NP_001372283.1",
"transcript_support_level": null,
"aa_start": 537,
"aa_end": null,
"aa_length": 600,
"cds_start": 1609,
"cds_end": null,
"cds_length": 1803,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001385354.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1609C>T",
"hgvs_p": "p.Pro537Ser",
"transcript": "NM_001385355.1",
"protein_id": "NP_001372284.1",
"transcript_support_level": null,
"aa_start": 537,
"aa_end": null,
"aa_length": 600,
"cds_start": 1609,
"cds_end": null,
"cds_length": 1803,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001385355.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"hgvs_c": "c.1609C>T",
"hgvs_p": "p.Pro537Ser",
"transcript": "ENST00000866400.1",
"protein_id": "ENSP00000536459.1",
"transcript_support_level": null,
"aa_start": 537,
"aa_end": null,
"aa_length": 600,
"cds_start": 1609,
"cds_end": null,
"cds_length": 1803,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047420328.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WDR86",
"gene_hgnc_id": 28020,
"hgvs_c": "n.494G>A",
"hgvs_p": null,
"transcript": "ENST00000463000.1",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000463000.1"
}
],
"gene_symbol": "NUB1",
"gene_hgnc_id": 17623,
"dbsnp": "rs1458457448",
"frequency_reference_population": 0.0000027911676,
"hom_count_reference_population": 0,
"allele_count_reference_population": 4,
"gnomad_exomes_af": 0.00000279117,
"gnomad_genomes_af": null,
"gnomad_exomes_ac": 4,
"gnomad_genomes_ac": null,
"gnomad_exomes_homalt": 0,
"gnomad_genomes_homalt": null,
"gnomad_mito_homoplasmic": null,
"gnomad_mito_heteroplasmic": null,
"computational_score_selected": 0.10454139113426208,
"computational_prediction_selected": "Benign",
"computational_source_selected": "MetaRNN",
"splice_score_selected": 0.009999999776482582,
"splice_prediction_selected": "Benign",
"splice_source_selected": "max_spliceai",
"revel_score": 0.082,
"revel_prediction": "Benign",
"alphamissense_score": 0.081,
"alphamissense_prediction": null,
"bayesdelnoaf_score": -0.58,
"bayesdelnoaf_prediction": "Benign",
"phylop100way_score": 2.423,
"phylop100way_prediction": "Benign",
"spliceai_max_score": 0.01,
"spliceai_max_prediction": "Benign",
"dbscsnv_ada_score": null,
"dbscsnv_ada_prediction": null,
"apogee2_score": null,
"apogee2_prediction": null,
"mitotip_score": null,
"mitotip_prediction": null,
"acmg_score": 0,
"acmg_classification": "Uncertain_significance",
"acmg_criteria": "PM2,BP4_Moderate",
"acmg_by_gene": [
{
"score": 0,
"benign_score": 2,
"pathogenic_score": 2,
"criteria": [
"PM2",
"BP4_Moderate"
],
"verdict": "Uncertain_significance",
"transcript": "NM_001243351.2",
"gene_symbol": "NUB1",
"hgnc_id": 17623,
"effects": [
"missense_variant"
],
"inheritance_mode": "AR",
"hgvs_c": "c.1654C>T",
"hgvs_p": "p.Pro552Ser"
},
{
"score": 0,
"benign_score": 2,
"pathogenic_score": 2,
"criteria": [
"PM2",
"BP4_Moderate"
],
"verdict": "Uncertain_significance",
"transcript": "ENST00000463000.1",
"gene_symbol": "WDR86",
"hgnc_id": 28020,
"effects": [
"non_coding_transcript_exon_variant"
],
"inheritance_mode": "AR",
"hgvs_c": "n.494G>A",
"hgvs_p": null
}
],
"clinvar_disease": "not specified",
"clinvar_classification": "Uncertain significance",
"clinvar_review_status": "criteria provided, single submitter",
"clinvar_submissions_summary": "US:1",
"phenotype_combined": "not specified",
"pathogenicity_classification_combined": "Uncertain significance",
"custom_annotations": null
}
],
"message": null
}