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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 7-151409544-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=151409544&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "7",
      "pos": 151409544,
      "ref": "C",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "NM_001284260.2",
      "consequences": [
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WDR86",
          "gene_hgnc_id": 28020,
          "hgvs_c": "c.46G>A",
          "hgvs_p": "p.Gly16Arg",
          "transcript": "NM_198285.3",
          "protein_id": "NP_938026.2",
          "transcript_support_level": null,
          "aa_start": 16,
          "aa_end": null,
          "aa_length": 376,
          "cds_start": 46,
          "cds_end": null,
          "cds_length": 1131,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000334493.11",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_198285.3"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WDR86",
          "gene_hgnc_id": 28020,
          "hgvs_c": "c.46G>A",
          "hgvs_p": "p.Gly16Arg",
          "transcript": "ENST00000334493.11",
          "protein_id": "ENSP00000335522.7",
          "transcript_support_level": 5,
          "aa_start": 16,
          "aa_end": null,
          "aa_length": 376,
          "cds_start": 46,
          "cds_end": null,
          "cds_length": 1131,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_198285.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000334493.11"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "WDR86-AS1",
          "gene_hgnc_id": 41186,
          "hgvs_c": "n.160+162C>T",
          "hgvs_p": null,
          "transcript": "ENST00000480632.6",
          "protein_id": null,
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000480632.6"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WDR86",
          "gene_hgnc_id": 28020,
          "hgvs_c": "c.46G>A",
          "hgvs_p": "p.Gly16Arg",
          "transcript": "NM_001284260.2",
          "protein_id": "NP_001271189.1",
          "transcript_support_level": null,
          "aa_start": 16,
          "aa_end": null,
          "aa_length": 482,
          "cds_start": 46,
          "cds_end": null,
          "cds_length": 1449,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001284260.2"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WDR86",
          "gene_hgnc_id": 28020,
          "hgvs_c": "c.46G>A",
          "hgvs_p": "p.Gly16Arg",
          "transcript": "ENST00000469830.2",
          "protein_id": "ENSP00000419162.2",
          "transcript_support_level": 2,
          "aa_start": 16,
          "aa_end": null,
          "aa_length": 482,
          "cds_start": 46,
          "cds_end": null,
          "cds_length": 1449,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000469830.2"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WDR86",
          "gene_hgnc_id": 28020,
          "hgvs_c": "c.46G>A",
          "hgvs_p": "p.Gly16Arg",
          "transcript": "XM_011516144.4",
          "protein_id": "XP_011514446.1",
          "transcript_support_level": null,
          "aa_start": 16,
          "aa_end": null,
          "aa_length": 468,
          "cds_start": 46,
          "cds_end": null,
          "cds_length": 1407,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011516144.4"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WDR86",
          "gene_hgnc_id": 28020,
          "hgvs_c": "c.46G>A",
          "hgvs_p": "p.Gly16Arg",
          "transcript": "XM_011516145.4",
          "protein_id": "XP_011514447.1",
          "transcript_support_level": null,
          "aa_start": 16,
          "aa_end": null,
          "aa_length": 425,
          "cds_start": 46,
          "cds_end": null,
          "cds_length": 1278,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011516145.4"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WDR86",
          "gene_hgnc_id": 28020,
          "hgvs_c": "c.46G>A",
          "hgvs_p": "p.Gly16Arg",
          "transcript": "XM_005249989.5",
          "protein_id": "XP_005250046.1",
          "transcript_support_level": null,
          "aa_start": 16,
          "aa_end": null,
          "aa_length": 405,
          "cds_start": 46,
          "cds_end": null,
          "cds_length": 1218,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_005249989.5"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WDR86",
          "gene_hgnc_id": 28020,
          "hgvs_c": "c.46G>A",
          "hgvs_p": "p.Gly16Arg",
          "transcript": "XM_011516146.4",
          "protein_id": "XP_011514448.1",
          "transcript_support_level": null,
          "aa_start": 16,
          "aa_end": null,
          "aa_length": 370,
          "cds_start": 46,
          "cds_end": null,
          "cds_length": 1113,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011516146.4"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WDR86",
          "gene_hgnc_id": 28020,
          "hgvs_c": "c.46G>A",
          "hgvs_p": "p.Gly16Arg",
          "transcript": "XM_011516147.4",
          "protein_id": "XP_011514449.1",
          "transcript_support_level": null,
          "aa_start": 16,
          "aa_end": null,
          "aa_length": 368,
          "cds_start": 46,
          "cds_end": null,
          "cds_length": 1107,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "XM_011516147.4"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 1,
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          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WDR86",
          "gene_hgnc_id": 28020,
          "hgvs_c": "c.46G>A",
          "hgvs_p": "p.Gly16Arg",
          "transcript": "XM_005249990.6",
          "protein_id": "XP_005250047.1",
          "transcript_support_level": null,
          "aa_start": 16,
          "aa_end": null,
          "aa_length": 327,
          "cds_start": 46,
          "cds_end": null,
          "cds_length": 984,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_005249990.6"
        },
        {
          "aa_ref": "G",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
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          "exon_count": 5,
          "intron_rank": null,
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          "gene_symbol": "WDR86",
          "gene_hgnc_id": 28020,
          "hgvs_c": "c.46G>A",
          "hgvs_p": "p.Gly16Arg",
          "transcript": "XM_006715966.4",
          "protein_id": "XP_006716029.1",
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          "aa_start": 16,
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          "cds_start": 46,
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          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "G",
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          "canonical": false,
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          ],
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          "intron_rank": null,
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          "gene_symbol": "WDR86",
          "gene_hgnc_id": 28020,
          "hgvs_c": "c.46G>A",
          "hgvs_p": "p.Gly16Arg",
          "transcript": "XM_011516151.4",
          "protein_id": "XP_011514453.1",
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          "cds_start": 46,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "G",
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          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 1,
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          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WDR86",
          "gene_hgnc_id": 28020,
          "hgvs_c": "c.46G>A",
          "hgvs_p": "p.Gly16Arg",
          "transcript": "XM_011516152.3",
          "protein_id": "XP_011514454.1",
          "transcript_support_level": null,
          "aa_start": 16,
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        {
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          ],
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          "gene_symbol": "WDR86",
          "gene_hgnc_id": 28020,
          "hgvs_c": "c.46G>A",
          "hgvs_p": "p.Gly16Arg",
          "transcript": "XM_047420326.1",
          "protein_id": "XP_047276282.1",
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": null,
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          "canonical": false,
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          "strand": false,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
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          "gene_symbol": "WDR86",
          "gene_hgnc_id": 28020,
          "hgvs_c": "c.-339G>A",
          "hgvs_p": null,
          "transcript": "ENST00000628331.1",
          "protein_id": "ENSP00000486705.1",
          "transcript_support_level": 5,
          "aa_start": null,
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          "cds_start": null,
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          "cdna_start": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": null,
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          "canonical": false,
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          "consequences": [
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          ],
          "exon_rank": null,
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          "exon_count": 5,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "WDR86",
          "gene_hgnc_id": 28020,
          "hgvs_c": "c.-222+1049G>A",
          "hgvs_p": null,
          "transcript": "NM_001284261.2",
          "protein_id": "NP_001271190.1",
          "transcript_support_level": null,
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        {
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          ],
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          "hgvs_c": "c.-222+1049G>A",
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          "transcript": "ENST00000477459.5",
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        {
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          ],
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          "gene_symbol": "WDR86",
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          "hgvs_c": "c.-222+1049G>A",
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          "transcript": "NM_001284262.2",
          "protein_id": "NP_001271191.1",
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        },
        {
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          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 6,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "WDR86",
          "gene_hgnc_id": 28020,
          "hgvs_c": "c.-222+1049G>A",
          "hgvs_p": null,
          "transcript": "ENST00000621812.2",
          "protein_id": "ENSP00000482209.1",
          "transcript_support_level": 5,
          "aa_start": null,
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          "cdna_start": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000621812.2"
        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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      "gnomad_exomes_homalt": 0,
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      "computational_score_selected": 0.3771234154701233,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0.019999999552965164,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.36,
      "revel_prediction": "Uncertain_significance",
      "alphamissense_score": 0.8363,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.07,
      "bayesdelnoaf_prediction": "Uncertain_significance",
      "phylop100way_score": 2.743,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0.02,
      "spliceai_max_prediction": "Benign",
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      "acmg_score": 1,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4",
      "acmg_by_gene": [
        {
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            "BP4"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_001284260.2",
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          "effects": [
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        {
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          ],
          "verdict": "Uncertain_significance",
          "transcript": "ENST00000480632.6",
          "gene_symbol": "WDR86-AS1",
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          "effects": [
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          "inheritance_mode": "",
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      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
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  ],
  "message": null
}