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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 7-24830877-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=24830877&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "7",
"pos": 24830877,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_015550.4",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "c.1775C>A",
"hgvs_p": "p.Ala592Glu",
"transcript": "NM_015550.4",
"protein_id": "NP_056365.1",
"transcript_support_level": null,
"aa_start": 592,
"aa_end": null,
"aa_length": 887,
"cds_start": 1775,
"cds_end": null,
"cds_length": 2664,
"cdna_start": 2217,
"cdna_end": null,
"cdna_length": 6749,
"mane_select": "ENST00000313367.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015550.4"
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "c.1775C>A",
"hgvs_p": "p.Ala592Glu",
"transcript": "ENST00000313367.7",
"protein_id": "ENSP00000315410.2",
"transcript_support_level": 1,
"aa_start": 592,
"aa_end": null,
"aa_length": 887,
"cds_start": 1775,
"cds_end": null,
"cds_length": 2664,
"cdna_start": 2217,
"cdna_end": null,
"cdna_length": 6749,
"mane_select": "NM_015550.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000313367.7"
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "c.1682C>A",
"hgvs_p": "p.Ala561Glu",
"transcript": "ENST00000396431.5",
"protein_id": "ENSP00000379708.1",
"transcript_support_level": 1,
"aa_start": 561,
"aa_end": null,
"aa_length": 856,
"cds_start": 1682,
"cds_end": null,
"cds_length": 2571,
"cdna_start": 1822,
"cdna_end": null,
"cdna_length": 2969,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000396431.5"
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "c.1667C>A",
"hgvs_p": "p.Ala556Glu",
"transcript": "ENST00000396429.5",
"protein_id": "ENSP00000379706.1",
"transcript_support_level": 1,
"aa_start": 556,
"aa_end": null,
"aa_length": 851,
"cds_start": 1667,
"cds_end": null,
"cds_length": 2556,
"cdna_start": 1770,
"cdna_end": null,
"cdna_length": 2707,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000396429.5"
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "c.1574C>A",
"hgvs_p": "p.Ala525Glu",
"transcript": "ENST00000409069.5",
"protein_id": "ENSP00000386953.1",
"transcript_support_level": 1,
"aa_start": 525,
"aa_end": null,
"aa_length": 820,
"cds_start": 1574,
"cds_end": null,
"cds_length": 2463,
"cdna_start": 1677,
"cdna_end": null,
"cdna_length": 2614,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000409069.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "n.*245C>A",
"hgvs_p": null,
"transcript": "ENST00000409452.5",
"protein_id": "ENSP00000386801.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3344,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000409452.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "n.*245C>A",
"hgvs_p": null,
"transcript": "ENST00000409863.5",
"protein_id": "ENSP00000386429.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3490,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000409863.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "n.*245C>A",
"hgvs_p": null,
"transcript": "ENST00000409452.5",
"protein_id": "ENSP00000386801.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3344,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000409452.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "n.*245C>A",
"hgvs_p": null,
"transcript": "ENST00000409863.5",
"protein_id": "ENSP00000386429.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3490,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000409863.5"
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "c.1745C>A",
"hgvs_p": "p.Ala582Glu",
"transcript": "ENST00000969022.1",
"protein_id": "ENSP00000639081.1",
"transcript_support_level": null,
"aa_start": 582,
"aa_end": null,
"aa_length": 877,
"cds_start": 1745,
"cds_end": null,
"cds_length": 2634,
"cdna_start": 2201,
"cdna_end": null,
"cdna_length": 6718,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969022.1"
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "c.1733C>A",
"hgvs_p": "p.Ala578Glu",
"transcript": "ENST00000940424.1",
"protein_id": "ENSP00000610483.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 873,
"cds_start": 1733,
"cds_end": null,
"cds_length": 2622,
"cdna_start": 2164,
"cdna_end": null,
"cdna_length": 6116,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940424.1"
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "c.1721C>A",
"hgvs_p": "p.Ala574Glu",
"transcript": "ENST00000898370.1",
"protein_id": "ENSP00000568429.1",
"transcript_support_level": null,
"aa_start": 574,
"aa_end": null,
"aa_length": 869,
"cds_start": 1721,
"cds_end": null,
"cds_length": 2610,
"cdna_start": 2111,
"cdna_end": null,
"cdna_length": 3711,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898370.1"
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "c.1682C>A",
"hgvs_p": "p.Ala561Glu",
"transcript": "NM_145320.2",
"protein_id": "NP_663160.1",
"transcript_support_level": null,
"aa_start": 561,
"aa_end": null,
"aa_length": 856,
"cds_start": 1682,
"cds_end": null,
"cds_length": 2571,
"cdna_start": 1831,
"cdna_end": null,
"cdna_length": 6366,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_145320.2"
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "c.1667C>A",
"hgvs_p": "p.Ala556Glu",
"transcript": "NM_145321.2",
"protein_id": "NP_663161.1",
"transcript_support_level": null,
"aa_start": 556,
"aa_end": null,
"aa_length": 851,
"cds_start": 1667,
"cds_end": null,
"cds_length": 2556,
"cdna_start": 1816,
"cdna_end": null,
"cdna_length": 6351,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_145321.2"
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "c.1574C>A",
"hgvs_p": "p.Ala525Glu",
"transcript": "NM_145322.2",
"protein_id": "NP_663162.1",
"transcript_support_level": null,
"aa_start": 525,
"aa_end": null,
"aa_length": 820,
"cds_start": 1574,
"cds_end": null,
"cds_length": 2463,
"cdna_start": 1723,
"cdna_end": null,
"cdna_length": 6258,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_145322.2"
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "c.1574C>A",
"hgvs_p": "p.Ala525Glu",
"transcript": "ENST00000940423.1",
"protein_id": "ENSP00000610482.1",
"transcript_support_level": null,
"aa_start": 525,
"aa_end": null,
"aa_length": 820,
"cds_start": 1574,
"cds_end": null,
"cds_length": 2463,
"cdna_start": 1997,
"cdna_end": null,
"cdna_length": 6529,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940423.1"
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "c.1532C>A",
"hgvs_p": "p.Ala511Glu",
"transcript": "ENST00000940425.1",
"protein_id": "ENSP00000610484.1",
"transcript_support_level": null,
"aa_start": 511,
"aa_end": null,
"aa_length": 806,
"cds_start": 1532,
"cds_end": null,
"cds_length": 2421,
"cdna_start": 1949,
"cdna_end": null,
"cdna_length": 3102,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940425.1"
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "c.1841C>A",
"hgvs_p": "p.Ala614Glu",
"transcript": "XM_047420129.1",
"protein_id": "XP_047276085.1",
"transcript_support_level": null,
"aa_start": 614,
"aa_end": null,
"aa_length": 909,
"cds_start": 1841,
"cds_end": null,
"cds_length": 2730,
"cdna_start": 2283,
"cdna_end": null,
"cdna_length": 6818,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047420129.1"
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "c.1841C>A",
"hgvs_p": "p.Ala614Glu",
"transcript": "XM_047420130.1",
"protein_id": "XP_047276086.1",
"transcript_support_level": null,
"aa_start": 614,
"aa_end": null,
"aa_length": 909,
"cds_start": 1841,
"cds_end": null,
"cds_length": 2730,
"cdna_start": 2171,
"cdna_end": null,
"cdna_length": 6706,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047420130.1"
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "c.1841C>A",
"hgvs_p": "p.Ala614Glu",
"transcript": "XM_047420131.1",
"protein_id": "XP_047276087.1",
"transcript_support_level": null,
"aa_start": 614,
"aa_end": null,
"aa_length": 909,
"cds_start": 1841,
"cds_end": null,
"cds_length": 2730,
"cdna_start": 2306,
"cdna_end": null,
"cdna_length": 6841,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047420131.1"
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "c.1841C>A",
"hgvs_p": "p.Ala614Glu",
"transcript": "XM_047420132.1",
"protein_id": "XP_047276088.1",
"transcript_support_level": null,
"aa_start": 614,
"aa_end": null,
"aa_length": 909,
"cds_start": 1841,
"cds_end": null,
"cds_length": 2730,
"cdna_start": 2081,
"cdna_end": null,
"cdna_length": 6616,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047420132.1"
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OSBPL3",
"gene_hgnc_id": 16370,
"hgvs_c": "c.1841C>A",
"hgvs_p": "p.Ala614Glu",
"transcript": "XM_047420133.1",
"protein_id": "XP_047276089.1",
"transcript_support_level": null,
"aa_start": 614,
"aa_end": null,
"aa_length": 909,
"cds_start": 1841,
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{
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"clinvar_disease": "",
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"clinvar_review_status": "",
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"custom_annotations": null
}
],
"message": null
}