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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 7-44114886-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=44114886&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [
            "PP3"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "POLD2",
          "hgnc_id": 9176,
          "hgvs_c": "c.1309G>A",
          "hgvs_p": "p.Ala437Thr",
          "inheritance_mode": "AR",
          "pathogenic_score": 1,
          "score": 1,
          "transcript": "NM_006230.4",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PP3",
      "acmg_score": 1,
      "allele_count_reference_population": 28,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.6841,
      "alt": "T",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Uncertain_significance",
      "bayesdelnoaf_score": 0.12,
      "chr": "7",
      "clinvar_classification": "Uncertain significance",
      "clinvar_disease": "not provided,not specified",
      "clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
      "clinvar_submissions_summary": "US:2",
      "computational_prediction_selected": "Pathogenic",
      "computational_score_selected": 0.7856996655464172,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 469,
          "aa_ref": "A",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1609,
          "cdna_start": 1403,
          "cds_end": null,
          "cds_length": 1410,
          "cds_start": 1309,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "NM_006230.4",
          "gene_hgnc_id": 9176,
          "gene_symbol": "POLD2",
          "hgvs_c": "c.1309G>A",
          "hgvs_p": "p.Ala437Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000610533.6",
          "protein_coding": true,
          "protein_id": "NP_006221.3",
          "strand": false,
          "transcript": "NM_006230.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 469,
          "aa_ref": "A",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 1609,
          "cdna_start": 1403,
          "cds_end": null,
          "cds_length": 1410,
          "cds_start": 1309,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000610533.6",
          "gene_hgnc_id": 9176,
          "gene_symbol": "POLD2",
          "hgvs_c": "c.1309G>A",
          "hgvs_p": "p.Ala437Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_006230.4",
          "protein_coding": true,
          "protein_id": "ENSP00000480186.2",
          "strand": false,
          "transcript": "ENST00000610533.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 469,
          "aa_ref": "A",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1659,
          "cdna_start": 1558,
          "cds_end": null,
          "cds_length": 1410,
          "cds_start": 1309,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000452185.5",
          "gene_hgnc_id": 9176,
          "gene_symbol": "POLD2",
          "hgvs_c": "c.1309G>A",
          "hgvs_p": "p.Ala437Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000395231.1",
          "strand": false,
          "transcript": "ENST00000452185.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 478,
          "aa_ref": "A",
          "aa_start": 446,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1627,
          "cdna_start": 1430,
          "cds_end": null,
          "cds_length": 1437,
          "cds_start": 1336,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000881309.1",
          "gene_hgnc_id": 9176,
          "gene_symbol": "POLD2",
          "hgvs_c": "c.1336G>A",
          "hgvs_p": "p.Ala446Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000551368.1",
          "strand": false,
          "transcript": "ENST00000881309.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 478,
          "aa_ref": "A",
          "aa_start": 446,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1783,
          "cdna_start": 1585,
          "cds_end": null,
          "cds_length": 1437,
          "cds_start": 1336,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000964235.1",
          "gene_hgnc_id": 9176,
          "gene_symbol": "POLD2",
          "hgvs_c": "c.1336G>A",
          "hgvs_p": "p.Ala446Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000634294.1",
          "strand": false,
          "transcript": "ENST00000964235.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 469,
          "aa_ref": "A",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1782,
          "cdna_start": 1576,
          "cds_end": null,
          "cds_length": 1410,
          "cds_start": 1309,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "NM_001127218.3",
          "gene_hgnc_id": 9176,
          "gene_symbol": "POLD2",
          "hgvs_c": "c.1309G>A",
          "hgvs_p": "p.Ala437Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001120690.1",
          "strand": false,
          "transcript": "NM_001127218.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 469,
          "aa_ref": "A",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2205,
          "cdna_start": 1999,
          "cds_end": null,
          "cds_length": 1410,
          "cds_start": 1309,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "NM_001256879.2",
          "gene_hgnc_id": 9176,
          "gene_symbol": "POLD2",
          "hgvs_c": "c.1309G>A",
          "hgvs_p": "p.Ala437Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001243808.1",
          "strand": false,
          "transcript": "NM_001256879.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 469,
          "aa_ref": "A",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2158,
          "cdna_start": 1959,
          "cds_end": null,
          "cds_length": 1410,
          "cds_start": 1309,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000406581.6",
          "gene_hgnc_id": 9176,
          "gene_symbol": "POLD2",
          "hgvs_c": "c.1309G>A",
          "hgvs_p": "p.Ala437Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000386105.2",
          "strand": false,
          "transcript": "ENST00000406581.6",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 469,
          "aa_ref": "A",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1676,
          "cdna_start": 1421,
          "cds_end": null,
          "cds_length": 1410,
          "cds_start": 1309,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000418438.2",
          "gene_hgnc_id": 9176,
          "gene_symbol": "POLD2",
          "hgvs_c": "c.1309G>A",
          "hgvs_p": "p.Ala437Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000406702.2",
          "strand": false,
          "transcript": "ENST00000418438.2",
          "transcript_support_level": 4
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 469,
          "aa_ref": "A",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1814,
          "cdna_start": 1615,
          "cds_end": null,
          "cds_length": 1410,
          "cds_start": 1309,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000698945.1",
          "gene_hgnc_id": 9176,
          "gene_symbol": "POLD2",
          "hgvs_c": "c.1309G>A",
          "hgvs_p": "p.Ala437Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000514051.1",
          "strand": false,
          "transcript": "ENST00000698945.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 469,
          "aa_ref": "A",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2304,
          "cdna_start": 2105,
          "cds_end": null,
          "cds_length": 1410,
          "cds_start": 1309,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000698946.1",
          "gene_hgnc_id": 9176,
          "gene_symbol": "POLD2",
          "hgvs_c": "c.1309G>A",
          "hgvs_p": "p.Ala437Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000514052.1",
          "strand": false,
          "transcript": "ENST00000698946.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 469,
          "aa_ref": "A",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1688,
          "cdna_start": 1489,
          "cds_end": null,
          "cds_length": 1410,
          "cds_start": 1309,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000698947.1",
          "gene_hgnc_id": 9176,
          "gene_symbol": "POLD2",
          "hgvs_c": "c.1309G>A",
          "hgvs_p": "p.Ala437Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000514053.1",
          "strand": false,
          "transcript": "ENST00000698947.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 469,
          "aa_ref": "A",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1661,
          "cdna_start": 1463,
          "cds_end": null,
          "cds_length": 1410,
          "cds_start": 1309,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000881299.1",
          "gene_hgnc_id": 9176,
          "gene_symbol": "POLD2",
          "hgvs_c": "c.1309G>A",
          "hgvs_p": "p.Ala437Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000551358.1",
          "strand": false,
          "transcript": "ENST00000881299.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 469,
          "aa_ref": "A",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1824,
          "cdna_start": 1625,
          "cds_end": null,
          "cds_length": 1410,
          "cds_start": 1309,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000881300.1",
          "gene_hgnc_id": 9176,
          "gene_symbol": "POLD2",
          "hgvs_c": "c.1309G>A",
          "hgvs_p": "p.Ala437Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000551359.1",
          "strand": false,
          "transcript": "ENST00000881300.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 469,
          "aa_ref": "A",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1779,
          "cdna_start": 1581,
          "cds_end": null,
          "cds_length": 1410,
          "cds_start": 1309,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000881304.1",
          "gene_hgnc_id": 9176,
          "gene_symbol": "POLD2",
          "hgvs_c": "c.1309G>A",
          "hgvs_p": "p.Ala437Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000551363.1",
          "strand": false,
          "transcript": "ENST00000881304.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 469,
          "aa_ref": "A",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1865,
          "cdna_start": 1667,
          "cds_end": null,
          "cds_length": 1410,
          "cds_start": 1309,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000881305.1",
          "gene_hgnc_id": 9176,
          "gene_symbol": "POLD2",
          "hgvs_c": "c.1309G>A",
          "hgvs_p": "p.Ala437Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000551364.1",
          "strand": false,
          "transcript": "ENST00000881305.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 469,
          "aa_ref": "A",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1813,
          "cdna_start": 1615,
          "cds_end": null,
          "cds_length": 1410,
          "cds_start": 1309,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000881316.1",
          "gene_hgnc_id": 9176,
          "gene_symbol": "POLD2",
          "hgvs_c": "c.1309G>A",
          "hgvs_p": "p.Ala437Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000551375.1",
          "strand": false,
          "transcript": "ENST00000881316.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 469,
          "aa_ref": "A",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2883,
          "cdna_start": 2685,
          "cds_end": null,
          "cds_length": 1410,
          "cds_start": 1309,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000881321.1",
          "gene_hgnc_id": 9176,
          "gene_symbol": "POLD2",
          "hgvs_c": "c.1309G>A",
          "hgvs_p": "p.Ala437Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000551380.1",
          "strand": false,
          "transcript": "ENST00000881321.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 469,
          "aa_ref": "A",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1855,
          "cdna_start": 1657,
          "cds_end": null,
          "cds_length": 1410,
          "cds_start": 1309,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000881322.1",
          "gene_hgnc_id": 9176,
          "gene_symbol": "POLD2",
          "hgvs_c": "c.1309G>A",
          "hgvs_p": "p.Ala437Thr",
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.