← Back to variant description

GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 7-44145594-GC-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=44145594&ref=GC&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "7",
      "pos": 44145594,
      "ref": "GC",
      "alt": "G",
      "effect": "frameshift_variant",
      "transcript": "ENST00000403799.8",
      "consequences": [
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "c.1155delG",
          "hgvs_p": "p.Leu386fs",
          "transcript": "NM_000162.5",
          "protein_id": "NP_000153.1",
          "transcript_support_level": null,
          "aa_start": 385,
          "aa_end": null,
          "aa_length": 465,
          "cds_start": 1155,
          "cds_end": null,
          "cds_length": 1398,
          "cdna_start": 1641,
          "cdna_end": null,
          "cdna_length": 2745,
          "mane_select": "ENST00000403799.8",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "c.1155delG",
          "hgvs_p": "p.Leu386fs",
          "transcript": "ENST00000403799.8",
          "protein_id": "ENSP00000384247.3",
          "transcript_support_level": 1,
          "aa_start": 385,
          "aa_end": null,
          "aa_length": 465,
          "cds_start": 1155,
          "cds_end": null,
          "cds_length": 1398,
          "cdna_start": 1641,
          "cdna_end": null,
          "cdna_length": 2745,
          "mane_select": "NM_000162.5",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "n.*1153delG",
          "hgvs_p": null,
          "transcript": "ENST00000395796.8",
          "protein_id": "ENSP00000379142.4",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2539,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "n.535delG",
          "hgvs_p": null,
          "transcript": "ENST00000459642.1",
          "protein_id": null,
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1641,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "n.*1153delG",
          "hgvs_p": null,
          "transcript": "ENST00000395796.8",
          "protein_id": "ENSP00000379142.4",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2539,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "c.1218delG",
          "hgvs_p": "p.Leu407fs",
          "transcript": "ENST00000671824.1",
          "protein_id": "ENSP00000500264.1",
          "transcript_support_level": null,
          "aa_start": 406,
          "aa_end": null,
          "aa_length": 486,
          "cds_start": 1218,
          "cds_end": null,
          "cds_length": 1461,
          "cdna_start": 1704,
          "cdna_end": null,
          "cdna_length": 2749,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "c.1158delG",
          "hgvs_p": "p.Leu387fs",
          "transcript": "NM_033507.3",
          "protein_id": "NP_277042.1",
          "transcript_support_level": null,
          "aa_start": 386,
          "aa_end": null,
          "aa_length": 466,
          "cds_start": 1158,
          "cds_end": null,
          "cds_length": 1401,
          "cdna_start": 1320,
          "cdna_end": null,
          "cdna_length": 2424,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "c.1158delG",
          "hgvs_p": "p.Leu387fs",
          "transcript": "ENST00000345378.7",
          "protein_id": "ENSP00000223366.2",
          "transcript_support_level": 2,
          "aa_start": 386,
          "aa_end": null,
          "aa_length": 466,
          "cds_start": 1158,
          "cds_end": null,
          "cds_length": 1401,
          "cdna_start": 1320,
          "cdna_end": null,
          "cdna_length": 2424,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "c.1152delG",
          "hgvs_p": "p.Leu385fs",
          "transcript": "NM_033508.3",
          "protein_id": "NP_277043.1",
          "transcript_support_level": null,
          "aa_start": 384,
          "aa_end": null,
          "aa_length": 464,
          "cds_start": 1152,
          "cds_end": null,
          "cds_length": 1395,
          "cdna_start": 1444,
          "cdna_end": null,
          "cdna_length": 2548,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "c.1155delG",
          "hgvs_p": "p.Leu386fs",
          "transcript": "NM_001354800.1",
          "protein_id": "NP_001341729.1",
          "transcript_support_level": null,
          "aa_start": 385,
          "aa_end": null,
          "aa_length": 456,
          "cds_start": 1155,
          "cds_end": null,
          "cds_length": 1371,
          "cdna_start": 1641,
          "cdna_end": null,
          "cdna_length": 2879,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "c.1155delG",
          "hgvs_p": "p.Leu386fs",
          "transcript": "ENST00000673284.1",
          "protein_id": "ENSP00000499852.1",
          "transcript_support_level": null,
          "aa_start": 385,
          "aa_end": null,
          "aa_length": 456,
          "cds_start": 1155,
          "cds_end": null,
          "cds_length": 1371,
          "cdna_start": 1641,
          "cdna_end": null,
          "cdna_length": 2879,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "c.1104delG",
          "hgvs_p": "p.Leu369fs",
          "transcript": "ENST00000437084.1",
          "protein_id": "ENSP00000402840.1",
          "transcript_support_level": 5,
          "aa_start": 368,
          "aa_end": null,
          "aa_length": 448,
          "cds_start": 1104,
          "cds_end": null,
          "cds_length": 1347,
          "cdna_start": 1138,
          "cdna_end": null,
          "cdna_length": 1385,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "c.189delG",
          "hgvs_p": "p.Leu64fs",
          "transcript": "NM_001354803.2",
          "protein_id": "NP_001341732.1",
          "transcript_support_level": null,
          "aa_start": 63,
          "aa_end": null,
          "aa_length": 143,
          "cds_start": 189,
          "cds_end": null,
          "cds_length": 432,
          "cdna_start": 207,
          "cdna_end": null,
          "cdna_length": 1311,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "c.189delG",
          "hgvs_p": "p.Leu64fs",
          "transcript": "ENST00000336642.9",
          "protein_id": "ENSP00000338009.5",
          "transcript_support_level": 2,
          "aa_start": 63,
          "aa_end": null,
          "aa_length": 143,
          "cds_start": 189,
          "cds_end": null,
          "cds_length": 432,
          "cdna_start": 207,
          "cdna_end": null,
          "cdna_length": 1311,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "c.144delG",
          "hgvs_p": "p.Leu49fs",
          "transcript": "NM_001354801.1",
          "protein_id": "NP_001341730.1",
          "transcript_support_level": null,
          "aa_start": 48,
          "aa_end": null,
          "aa_length": 128,
          "cds_start": 144,
          "cds_end": null,
          "cds_length": 387,
          "cdna_start": 151,
          "cdna_end": null,
          "cdna_length": 1259,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "c.15delG",
          "hgvs_p": "p.Leu6fs",
          "transcript": "NM_001354802.1",
          "protein_id": "NP_001341731.1",
          "transcript_support_level": null,
          "aa_start": 5,
          "aa_end": null,
          "aa_length": 76,
          "cds_start": 15,
          "cds_end": null,
          "cds_length": 231,
          "cdna_start": 372,
          "cdna_end": null,
          "cdna_length": 1610,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "c.15delG",
          "hgvs_p": "p.Leu6fs",
          "transcript": "XM_024446707.2",
          "protein_id": "XP_024302475.1",
          "transcript_support_level": null,
          "aa_start": 5,
          "aa_end": null,
          "aa_length": 85,
          "cds_start": 15,
          "cds_end": null,
          "cds_length": 258,
          "cdna_start": 372,
          "cdna_end": null,
          "cdna_length": 1480,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "n.*275delG",
          "hgvs_p": null,
          "transcript": "ENST00000616242.5",
          "protein_id": "ENSP00000482149.2",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2686,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "n.167delG",
          "hgvs_p": null,
          "transcript": "ENST00000672743.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 846,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "n.381delG",
          "hgvs_p": null,
          "transcript": "ENST00000683378.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1432,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ENSG00000300758",
          "gene_hgnc_id": null,
          "hgvs_c": "n.25delC",
          "hgvs_p": null,
          "transcript": "ENST00000773856.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1210,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ENSG00000300758",
          "gene_hgnc_id": null,
          "hgvs_c": "n.24delC",
          "hgvs_p": null,
          "transcript": "ENST00000773857.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1381,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "n.*275delG",
          "hgvs_p": null,
          "transcript": "ENST00000616242.5",
          "protein_id": "ENSP00000482149.2",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2686,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "downstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GCK",
          "gene_hgnc_id": 4195,
          "hgvs_c": "n.*49delG",
          "hgvs_p": null,
          "transcript": "ENST00000473353.1",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 404,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        }
      ],
      "gene_symbol": "GCK",
      "gene_hgnc_id": 4195,
      "dbsnp": "rs1400535021",
      "frequency_reference_population": 6.8785255e-7,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 1,
      "gnomad_exomes_af": 6.87853e-7,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": 1,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": null,
      "computational_prediction_selected": null,
      "computational_source_selected": null,
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": null,
      "bayesdelnoaf_prediction": null,
      "phylop100way_score": -0.317,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 18,
      "acmg_classification": "Pathogenic",
      "acmg_criteria": "PVS1,PM2,PP5_Very_Strong",
      "acmg_by_gene": [
        {
          "score": 18,
          "benign_score": 0,
          "pathogenic_score": 18,
          "criteria": [
            "PVS1",
            "PM2",
            "PP5_Very_Strong"
          ],
          "verdict": "Pathogenic",
          "transcript": "ENST00000403799.8",
          "gene_symbol": "GCK",
          "hgnc_id": 4195,
          "effects": [
            "frameshift_variant"
          ],
          "inheritance_mode": "AR,AD",
          "hgvs_c": "c.1155delG",
          "hgvs_p": "p.Leu386fs"
        },
        {
          "score": 10,
          "benign_score": 0,
          "pathogenic_score": 10,
          "criteria": [
            "PM2",
            "PP5_Very_Strong"
          ],
          "verdict": "Pathogenic",
          "transcript": "ENST00000773856.1",
          "gene_symbol": "ENSG00000300758",
          "hgnc_id": null,
          "effects": [
            "non_coding_transcript_exon_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.25delC",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "Hyperinsulinism due to glucokinase deficiency,Maturity onset diabetes mellitus in young,Maturity-onset diabetes of the young type 2,Permanent neonatal diabetes mellitus 1,Type 2 diabetes mellitus,not provided",
      "clinvar_classification": "Pathogenic/Likely pathogenic",
      "clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
      "clinvar_submissions_summary": "P:1 LP:5 US:1",
      "phenotype_combined": "not provided|Maturity-onset diabetes of the young type 2|Maturity onset diabetes mellitus in young|Type 2 diabetes mellitus|Hyperinsulinism due to glucokinase deficiency|Permanent neonatal diabetes mellitus 1",
      "pathogenicity_classification_combined": "Pathogenic/Likely pathogenic",
      "custom_annotations": null
    }
  ],
  "message": null
}