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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 7-44696501-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=44696501&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "7",
"pos": 44696501,
"ref": "C",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_001439007.1",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1844C>A",
"hgvs_p": "p.Thr615Lys",
"transcript": "NM_002541.4",
"protein_id": "NP_002532.2",
"transcript_support_level": null,
"aa_start": 615,
"aa_end": null,
"aa_length": 1023,
"cds_start": 1844,
"cds_end": null,
"cds_length": 3072,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000222673.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_002541.4"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1844C>A",
"hgvs_p": "p.Thr615Lys",
"transcript": "ENST00000222673.6",
"protein_id": "ENSP00000222673.5",
"transcript_support_level": 1,
"aa_start": 615,
"aa_end": null,
"aa_length": 1023,
"cds_start": 1844,
"cds_end": null,
"cds_length": 3072,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_002541.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000222673.6"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1976C>A",
"hgvs_p": "p.Thr659Lys",
"transcript": "ENST00000962345.1",
"protein_id": "ENSP00000632404.1",
"transcript_support_level": null,
"aa_start": 659,
"aa_end": null,
"aa_length": 1067,
"cds_start": 1976,
"cds_end": null,
"cds_length": 3204,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962345.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1964C>A",
"hgvs_p": "p.Thr655Lys",
"transcript": "ENST00000906382.1",
"protein_id": "ENSP00000576441.1",
"transcript_support_level": null,
"aa_start": 655,
"aa_end": null,
"aa_length": 1063,
"cds_start": 1964,
"cds_end": null,
"cds_length": 3192,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906382.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1931C>A",
"hgvs_p": "p.Thr644Lys",
"transcript": "ENST00000906372.1",
"protein_id": "ENSP00000576431.1",
"transcript_support_level": null,
"aa_start": 644,
"aa_end": null,
"aa_length": 1052,
"cds_start": 1931,
"cds_end": null,
"cds_length": 3159,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906372.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1931C>A",
"hgvs_p": "p.Thr644Lys",
"transcript": "ENST00000930777.1",
"protein_id": "ENSP00000600836.1",
"transcript_support_level": null,
"aa_start": 644,
"aa_end": null,
"aa_length": 1052,
"cds_start": 1931,
"cds_end": null,
"cds_length": 3159,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000930777.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1922C>A",
"hgvs_p": "p.Thr641Lys",
"transcript": "ENST00000906377.1",
"protein_id": "ENSP00000576436.1",
"transcript_support_level": null,
"aa_start": 641,
"aa_end": null,
"aa_length": 1049,
"cds_start": 1922,
"cds_end": null,
"cds_length": 3150,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906377.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1889C>A",
"hgvs_p": "p.Thr630Lys",
"transcript": "NM_001439007.1",
"protein_id": "NP_001425936.1",
"transcript_support_level": null,
"aa_start": 630,
"aa_end": null,
"aa_length": 1038,
"cds_start": 1889,
"cds_end": null,
"cds_length": 3117,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439007.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1889C>A",
"hgvs_p": "p.Thr630Lys",
"transcript": "ENST00000444676.5",
"protein_id": "ENSP00000414662.1",
"transcript_support_level": 5,
"aa_start": 630,
"aa_end": null,
"aa_length": 1038,
"cds_start": 1889,
"cds_end": null,
"cds_length": 3117,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000444676.5"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1889C>A",
"hgvs_p": "p.Thr630Lys",
"transcript": "ENST00000906378.1",
"protein_id": "ENSP00000576437.1",
"transcript_support_level": null,
"aa_start": 630,
"aa_end": null,
"aa_length": 1038,
"cds_start": 1889,
"cds_end": null,
"cds_length": 3117,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906378.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1889C>A",
"hgvs_p": "p.Thr630Lys",
"transcript": "ENST00000906396.1",
"protein_id": "ENSP00000576455.1",
"transcript_support_level": null,
"aa_start": 630,
"aa_end": null,
"aa_length": 1038,
"cds_start": 1889,
"cds_end": null,
"cds_length": 3117,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906396.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1886C>A",
"hgvs_p": "p.Thr629Lys",
"transcript": "ENST00000962344.1",
"protein_id": "ENSP00000632403.1",
"transcript_support_level": null,
"aa_start": 629,
"aa_end": null,
"aa_length": 1037,
"cds_start": 1886,
"cds_end": null,
"cds_length": 3114,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962344.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1877C>A",
"hgvs_p": "p.Thr626Lys",
"transcript": "NM_001363523.2",
"protein_id": "NP_001350452.1",
"transcript_support_level": null,
"aa_start": 626,
"aa_end": null,
"aa_length": 1034,
"cds_start": 1877,
"cds_end": null,
"cds_length": 3105,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001363523.2"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1877C>A",
"hgvs_p": "p.Thr626Lys",
"transcript": "ENST00000447398.6",
"protein_id": "ENSP00000388183.1",
"transcript_support_level": 5,
"aa_start": 626,
"aa_end": null,
"aa_length": 1034,
"cds_start": 1877,
"cds_end": null,
"cds_length": 3105,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000447398.6"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1877C>A",
"hgvs_p": "p.Thr626Lys",
"transcript": "ENST00000906369.1",
"protein_id": "ENSP00000576428.1",
"transcript_support_level": null,
"aa_start": 626,
"aa_end": null,
"aa_length": 1034,
"cds_start": 1877,
"cds_end": null,
"cds_length": 3105,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906369.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1877C>A",
"hgvs_p": "p.Thr626Lys",
"transcript": "ENST00000906387.1",
"protein_id": "ENSP00000576446.1",
"transcript_support_level": null,
"aa_start": 626,
"aa_end": null,
"aa_length": 1034,
"cds_start": 1877,
"cds_end": null,
"cds_length": 3105,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906387.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1877C>A",
"hgvs_p": "p.Thr626Lys",
"transcript": "ENST00000906399.1",
"protein_id": "ENSP00000576458.1",
"transcript_support_level": null,
"aa_start": 626,
"aa_end": null,
"aa_length": 1034,
"cds_start": 1877,
"cds_end": null,
"cds_length": 3105,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906399.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1877C>A",
"hgvs_p": "p.Thr626Lys",
"transcript": "ENST00000930779.1",
"protein_id": "ENSP00000600838.1",
"transcript_support_level": null,
"aa_start": 626,
"aa_end": null,
"aa_length": 1034,
"cds_start": 1877,
"cds_end": null,
"cds_length": 3105,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000930779.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1865C>A",
"hgvs_p": "p.Thr622Lys",
"transcript": "ENST00000906383.1",
"protein_id": "ENSP00000576442.1",
"transcript_support_level": null,
"aa_start": 622,
"aa_end": null,
"aa_length": 1030,
"cds_start": 1865,
"cds_end": null,
"cds_length": 3093,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906383.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1865C>A",
"hgvs_p": "p.Thr622Lys",
"transcript": "ENST00000906388.1",
"protein_id": "ENSP00000576447.1",
"transcript_support_level": null,
"aa_start": 622,
"aa_end": null,
"aa_length": 1030,
"cds_start": 1865,
"cds_end": null,
"cds_length": 3093,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906388.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1889C>A",
"hgvs_p": "p.Thr630Lys",
"transcript": "ENST00000906386.1",
"protein_id": "ENSP00000576445.1",
"transcript_support_level": null,
"aa_start": 630,
"aa_end": null,
"aa_length": 1027,
"cds_start": 1889,
"cds_end": null,
"cds_length": 3084,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906386.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OGDH",
"gene_hgnc_id": 8124,
"hgvs_c": "c.1844C>A",
"hgvs_p": "p.Thr615Lys",
"transcript": "NM_001439008.1",
"protein_id": "NP_001425937.1",
"transcript_support_level": null,
"aa_start": 615,
"aa_end": null,
"aa_length": 1023,
"cds_start": 1844,
"cds_end": null,
"cds_length": 3072,
"cdna_start": null,
"cdna_end": null,
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