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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 7-44760577-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=44760577&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "7",
"pos": 44760577,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_031449.4",
"consequences": [
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "c.1224G>T",
"hgvs_p": "p.Leu408Phe",
"transcript": "NM_031449.4",
"protein_id": "NP_113637.3",
"transcript_support_level": null,
"aa_start": 408,
"aa_end": null,
"aa_length": 920,
"cds_start": 1224,
"cds_end": null,
"cds_length": 2763,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000309315.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_031449.4"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "c.1224G>T",
"hgvs_p": "p.Leu408Phe",
"transcript": "ENST00000309315.9",
"protein_id": "ENSP00000311778.4",
"transcript_support_level": 2,
"aa_start": 408,
"aa_end": null,
"aa_length": 920,
"cds_start": 1224,
"cds_end": null,
"cds_length": 2763,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_031449.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000309315.9"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "c.1224G>T",
"hgvs_p": "p.Leu408Phe",
"transcript": "ENST00000441627.5",
"protein_id": "ENSP00000414723.1",
"transcript_support_level": 1,
"aa_start": 408,
"aa_end": null,
"aa_length": 920,
"cds_start": 1224,
"cds_end": null,
"cds_length": 2763,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000441627.5"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "c.1050G>T",
"hgvs_p": "p.Leu350Phe",
"transcript": "ENST00000413916.5",
"protein_id": "ENSP00000409648.1",
"transcript_support_level": 1,
"aa_start": 350,
"aa_end": null,
"aa_length": 862,
"cds_start": 1050,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000413916.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "n.844G>T",
"hgvs_p": null,
"transcript": "ENST00000478045.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000478045.5"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "c.1224G>T",
"hgvs_p": "p.Leu408Phe",
"transcript": "ENST00000884708.1",
"protein_id": "ENSP00000554767.1",
"transcript_support_level": null,
"aa_start": 408,
"aa_end": null,
"aa_length": 929,
"cds_start": 1224,
"cds_end": null,
"cds_length": 2790,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884708.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "c.1224G>T",
"hgvs_p": "p.Leu408Phe",
"transcript": "ENST00000931488.1",
"protein_id": "ENSP00000601547.1",
"transcript_support_level": null,
"aa_start": 408,
"aa_end": null,
"aa_length": 929,
"cds_start": 1224,
"cds_end": null,
"cds_length": 2790,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931488.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "c.1239G>T",
"hgvs_p": "p.Leu413Phe",
"transcript": "ENST00000931490.1",
"protein_id": "ENSP00000601549.1",
"transcript_support_level": null,
"aa_start": 413,
"aa_end": null,
"aa_length": 925,
"cds_start": 1239,
"cds_end": null,
"cds_length": 2778,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931490.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "c.1224G>T",
"hgvs_p": "p.Leu408Phe",
"transcript": "ENST00000931484.1",
"protein_id": "ENSP00000601543.1",
"transcript_support_level": null,
"aa_start": 408,
"aa_end": null,
"aa_length": 920,
"cds_start": 1224,
"cds_end": null,
"cds_length": 2763,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931484.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "c.1224G>T",
"hgvs_p": "p.Leu408Phe",
"transcript": "ENST00000931487.1",
"protein_id": "ENSP00000601546.1",
"transcript_support_level": null,
"aa_start": 408,
"aa_end": null,
"aa_length": 920,
"cds_start": 1224,
"cds_end": null,
"cds_length": 2763,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931487.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "c.1224G>T",
"hgvs_p": "p.Leu408Phe",
"transcript": "ENST00000884711.1",
"protein_id": "ENSP00000554770.1",
"transcript_support_level": null,
"aa_start": 408,
"aa_end": null,
"aa_length": 914,
"cds_start": 1224,
"cds_end": null,
"cds_length": 2745,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884711.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "c.1224G>T",
"hgvs_p": "p.Leu408Phe",
"transcript": "ENST00000931491.1",
"protein_id": "ENSP00000601550.1",
"transcript_support_level": null,
"aa_start": 408,
"aa_end": null,
"aa_length": 914,
"cds_start": 1224,
"cds_end": null,
"cds_length": 2745,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931491.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "c.1146G>T",
"hgvs_p": "p.Leu382Phe",
"transcript": "ENST00000884707.1",
"protein_id": "ENSP00000554766.1",
"transcript_support_level": null,
"aa_start": 382,
"aa_end": null,
"aa_length": 903,
"cds_start": 1146,
"cds_end": null,
"cds_length": 2712,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884707.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "c.1146G>T",
"hgvs_p": "p.Leu382Phe",
"transcript": "ENST00000884712.1",
"protein_id": "ENSP00000554771.1",
"transcript_support_level": null,
"aa_start": 382,
"aa_end": null,
"aa_length": 903,
"cds_start": 1146,
"cds_end": null,
"cds_length": 2712,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884712.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "c.1146G>T",
"hgvs_p": "p.Leu382Phe",
"transcript": "ENST00000884713.1",
"protein_id": "ENSP00000554772.1",
"transcript_support_level": null,
"aa_start": 382,
"aa_end": null,
"aa_length": 903,
"cds_start": 1146,
"cds_end": null,
"cds_length": 2712,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884713.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "c.1146G>T",
"hgvs_p": "p.Leu382Phe",
"transcript": "ENST00000884706.1",
"protein_id": "ENSP00000554765.1",
"transcript_support_level": null,
"aa_start": 382,
"aa_end": null,
"aa_length": 897,
"cds_start": 1146,
"cds_end": null,
"cds_length": 2694,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884706.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "c.1128G>T",
"hgvs_p": "p.Leu376Phe",
"transcript": "ENST00000931486.1",
"protein_id": "ENSP00000601545.1",
"transcript_support_level": null,
"aa_start": 376,
"aa_end": null,
"aa_length": 897,
"cds_start": 1128,
"cds_end": null,
"cds_length": 2694,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931486.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "c.1146G>T",
"hgvs_p": "p.Leu382Phe",
"transcript": "NM_174929.2",
"protein_id": "NP_777589.2",
"transcript_support_level": null,
"aa_start": 382,
"aa_end": null,
"aa_length": 894,
"cds_start": 1146,
"cds_end": null,
"cds_length": 2685,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_174929.2"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "c.1146G>T",
"hgvs_p": "p.Leu382Phe",
"transcript": "ENST00000265346.11",
"protein_id": "ENSP00000265346.7",
"transcript_support_level": 5,
"aa_start": 382,
"aa_end": null,
"aa_length": 894,
"cds_start": 1146,
"cds_end": null,
"cds_length": 2685,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000265346.11"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "c.1128G>T",
"hgvs_p": "p.Leu376Phe",
"transcript": "ENST00000433667.5",
"protein_id": "ENSP00000396601.1",
"transcript_support_level": 5,
"aa_start": 376,
"aa_end": null,
"aa_length": 888,
"cds_start": 1128,
"cds_end": null,
"cds_length": 2667,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000433667.5"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "c.1146G>T",
"hgvs_p": "p.Leu382Phe",
"transcript": "ENST00000944840.1",
"protein_id": "ENSP00000614899.1",
"transcript_support_level": null,
"aa_start": 382,
"aa_end": null,
"aa_length": 888,
"cds_start": 1146,
"cds_end": null,
"cds_length": 2667,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000944840.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZMIZ2",
"gene_hgnc_id": 22229,
"hgvs_c": "c.1224G>T",
"hgvs_p": "p.Leu408Phe",
"transcript": "ENST00000884710.1",
"protein_id": "ENSP00000554769.1",
"transcript_support_level": null,
"aa_start": 408,
"aa_end": null,
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}