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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 7-47303192-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=47303192&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "7",
"pos": 47303192,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "ENST00000311160.14",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.3215C>A",
"hgvs_p": "p.Thr1072Lys",
"transcript": "NM_022748.12",
"protein_id": "NP_073585.8",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1445,
"cds_start": 3215,
"cds_end": null,
"cds_length": 4338,
"cdna_start": 3540,
"cdna_end": null,
"cdna_length": 7585,
"mane_select": "ENST00000311160.14",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.3215C>A",
"hgvs_p": "p.Thr1072Lys",
"transcript": "ENST00000311160.14",
"protein_id": "ENSP00000312143.9",
"transcript_support_level": 1,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1445,
"cds_start": 3215,
"cds_end": null,
"cds_length": 4338,
"cdna_start": 3540,
"cdna_end": null,
"cdna_length": 7585,
"mane_select": "NM_022748.12",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.3557C>A",
"hgvs_p": "p.Thr1186Lys",
"transcript": "NM_001410877.1",
"protein_id": "NP_001397806.1",
"transcript_support_level": null,
"aa_start": 1186,
"aa_end": null,
"aa_length": 1559,
"cds_start": 3557,
"cds_end": null,
"cds_length": 4680,
"cdna_start": 3922,
"cdna_end": null,
"cdna_length": 7967,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.3557C>A",
"hgvs_p": "p.Thr1186Lys",
"transcript": "ENST00000705350.1",
"protein_id": "ENSP00000516118.1",
"transcript_support_level": null,
"aa_start": 1186,
"aa_end": null,
"aa_length": 1559,
"cds_start": 3557,
"cds_end": null,
"cds_length": 4680,
"cdna_start": 3792,
"cdna_end": null,
"cdna_length": 7837,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.3524C>A",
"hgvs_p": "p.Thr1175Lys",
"transcript": "NM_001410878.1",
"protein_id": "NP_001397807.1",
"transcript_support_level": null,
"aa_start": 1175,
"aa_end": null,
"aa_length": 1548,
"cds_start": 3524,
"cds_end": null,
"cds_length": 4647,
"cdna_start": 3639,
"cdna_end": null,
"cdna_length": 7684,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.3524C>A",
"hgvs_p": "p.Thr1175Lys",
"transcript": "ENST00000457718.6",
"protein_id": "ENSP00000414358.2",
"transcript_support_level": 5,
"aa_start": 1175,
"aa_end": null,
"aa_length": 1548,
"cds_start": 3524,
"cds_end": null,
"cds_length": 4647,
"cdna_start": 3611,
"cdna_end": null,
"cdna_length": 7656,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.3482C>A",
"hgvs_p": "p.Thr1161Lys",
"transcript": "ENST00000450444.6",
"protein_id": "ENSP00000396914.2",
"transcript_support_level": 5,
"aa_start": 1161,
"aa_end": null,
"aa_length": 1534,
"cds_start": 3482,
"cds_end": null,
"cds_length": 4605,
"cdna_start": 3682,
"cdna_end": null,
"cdna_length": 7727,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.1886C>A",
"hgvs_p": "p.Thr629Lys",
"transcript": "ENST00000705474.1",
"protein_id": "ENSP00000516130.1",
"transcript_support_level": null,
"aa_start": 629,
"aa_end": null,
"aa_length": 1002,
"cds_start": 1886,
"cds_end": null,
"cds_length": 3009,
"cdna_start": 2529,
"cdna_end": null,
"cdna_length": 6572,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.524C>A",
"hgvs_p": "p.Thr175Lys",
"transcript": "ENST00000705473.1",
"protein_id": "ENSP00000516129.1",
"transcript_support_level": null,
"aa_start": 175,
"aa_end": null,
"aa_length": 548,
"cds_start": 524,
"cds_end": null,
"cds_length": 1647,
"cdna_start": 723,
"cdna_end": null,
"cdna_length": 4766,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.524C>A",
"hgvs_p": "p.Thr175Lys",
"transcript": "ENST00000705472.1",
"protein_id": "ENSP00000516128.1",
"transcript_support_level": null,
"aa_start": 175,
"aa_end": null,
"aa_length": 501,
"cds_start": 524,
"cds_end": null,
"cds_length": 1506,
"cdna_start": 723,
"cdna_end": null,
"cdna_length": 4725,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.3605C>A",
"hgvs_p": "p.Thr1202Lys",
"transcript": "XM_047420723.1",
"protein_id": "XP_047276679.1",
"transcript_support_level": null,
"aa_start": 1202,
"aa_end": null,
"aa_length": 1575,
"cds_start": 3605,
"cds_end": null,
"cds_length": 4728,
"cdna_start": 3711,
"cdna_end": null,
"cdna_length": 7756,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.3605C>A",
"hgvs_p": "p.Thr1202Lys",
"transcript": "XM_047420724.1",
"protein_id": "XP_047276680.1",
"transcript_support_level": null,
"aa_start": 1202,
"aa_end": null,
"aa_length": 1575,
"cds_start": 3605,
"cds_end": null,
"cds_length": 4728,
"cdna_start": 3718,
"cdna_end": null,
"cdna_length": 7763,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.3563C>A",
"hgvs_p": "p.Thr1188Lys",
"transcript": "XM_047420725.1",
"protein_id": "XP_047276681.1",
"transcript_support_level": null,
"aa_start": 1188,
"aa_end": null,
"aa_length": 1561,
"cds_start": 3563,
"cds_end": null,
"cds_length": 4686,
"cdna_start": 3654,
"cdna_end": null,
"cdna_length": 7699,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.3524C>A",
"hgvs_p": "p.Thr1175Lys",
"transcript": "XM_017012537.2",
"protein_id": "XP_016868026.1",
"transcript_support_level": null,
"aa_start": 1175,
"aa_end": null,
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"cds_start": 3524,
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"cdna_start": 3554,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.3518C>A",
"hgvs_p": "p.Thr1173Lys",
"transcript": "XM_047420726.1",
"protein_id": "XP_047276682.1",
"transcript_support_level": null,
"aa_start": 1173,
"aa_end": null,
"aa_length": 1546,
"cds_start": 3518,
"cds_end": null,
"cds_length": 4641,
"cdna_start": 3883,
"cdna_end": null,
"cdna_length": 7928,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.3491C>A",
"hgvs_p": "p.Thr1164Lys",
"transcript": "XM_047420728.1",
"protein_id": "XP_047276684.1",
"transcript_support_level": null,
"aa_start": 1164,
"aa_end": null,
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"cds_start": 3491,
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"cdna_start": 3597,
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"cdna_length": 7642,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.3485C>A",
"hgvs_p": "p.Thr1162Lys",
"transcript": "XM_047420729.1",
"protein_id": "XP_047276685.1",
"transcript_support_level": null,
"aa_start": 1162,
"aa_end": null,
"aa_length": 1535,
"cds_start": 3485,
"cds_end": null,
"cds_length": 4608,
"cdna_start": 3600,
"cdna_end": null,
"cdna_length": 7645,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.3482C>A",
"hgvs_p": "p.Thr1161Lys",
"transcript": "XM_011515478.3",
"protein_id": "XP_011513780.1",
"transcript_support_level": null,
"aa_start": 1161,
"aa_end": null,
"aa_length": 1534,
"cds_start": 3482,
"cds_end": null,
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"cdna_start": 3649,
"cdna_end": null,
"cdna_length": 7694,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.3344C>A",
"hgvs_p": "p.Thr1115Lys",
"transcript": "XM_011515479.3",
"protein_id": "XP_011513781.1",
"transcript_support_level": null,
"aa_start": 1115,
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"cdna_start": 3537,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.3215C>A",
"hgvs_p": "p.Thr1072Lys",
"transcript": "XM_011515480.4",
"protein_id": "XP_011513782.1",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1445,
"cds_start": 3215,
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"cdna_start": 3608,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.3215C>A",
"hgvs_p": "p.Thr1072Lys",
"transcript": "XM_011515481.3",
"protein_id": "XP_011513783.1",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1445,
"cds_start": 3215,
"cds_end": null,
"cds_length": 4338,
"cdna_start": 3368,
"cdna_end": null,
"cdna_length": 7413,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNS3",
"gene_hgnc_id": 21616,
"hgvs_c": "c.3215C>A",
"hgvs_p": "p.Thr1072Lys",
"transcript": "XM_011515483.3",
"protein_id": "XP_011513785.1",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1445,
"cds_start": 3215,
"cds_end": null,
"cds_length": 4338,
"cdna_start": 3657,
"cdna_end": null,
"cdna_length": 7702,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
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}