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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 7-6409890-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=6409890&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "7",
      "pos": 6409890,
      "ref": "C",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "NM_139179.4",
      "consequences": [
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.1966G>A",
          "hgvs_p": "p.Ala656Thr",
          "transcript": "NM_139179.4",
          "protein_id": "NP_631918.3",
          "transcript_support_level": null,
          "aa_start": 656,
          "aa_end": null,
          "aa_length": 672,
          "cds_start": 1966,
          "cds_end": null,
          "cds_length": 2019,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000297056.11",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_139179.4"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.1966G>A",
          "hgvs_p": "p.Ala656Thr",
          "transcript": "ENST00000297056.11",
          "protein_id": "ENSP00000297056.6",
          "transcript_support_level": 1,
          "aa_start": 656,
          "aa_end": null,
          "aa_length": 672,
          "cds_start": 1966,
          "cds_end": null,
          "cds_length": 2019,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_139179.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000297056.11"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.2074G>A",
          "hgvs_p": "p.Ala692Thr",
          "transcript": "ENST00000878465.1",
          "protein_id": "ENSP00000548524.1",
          "transcript_support_level": null,
          "aa_start": 692,
          "aa_end": null,
          "aa_length": 708,
          "cds_start": 2074,
          "cds_end": null,
          "cds_length": 2127,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000878465.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.1960G>A",
          "hgvs_p": "p.Ala654Thr",
          "transcript": "ENST00000878464.1",
          "protein_id": "ENSP00000548523.1",
          "transcript_support_level": null,
          "aa_start": 654,
          "aa_end": null,
          "aa_length": 670,
          "cds_start": 1960,
          "cds_end": null,
          "cds_length": 2013,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000878464.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.1930G>A",
          "hgvs_p": "p.Ala644Thr",
          "transcript": "ENST00000878463.1",
          "protein_id": "ENSP00000548522.1",
          "transcript_support_level": null,
          "aa_start": 644,
          "aa_end": null,
          "aa_length": 660,
          "cds_start": 1930,
          "cds_end": null,
          "cds_length": 1983,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000878463.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.1888G>A",
          "hgvs_p": "p.Ala630Thr",
          "transcript": "ENST00000878457.1",
          "protein_id": "ENSP00000548516.1",
          "transcript_support_level": null,
          "aa_start": 630,
          "aa_end": null,
          "aa_length": 646,
          "cds_start": 1888,
          "cds_end": null,
          "cds_length": 1941,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000878457.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.1882G>A",
          "hgvs_p": "p.Ala628Thr",
          "transcript": "ENST00000878456.1",
          "protein_id": "ENSP00000548515.1",
          "transcript_support_level": null,
          "aa_start": 628,
          "aa_end": null,
          "aa_length": 644,
          "cds_start": 1882,
          "cds_end": null,
          "cds_length": 1935,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000878456.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.1843G>A",
          "hgvs_p": "p.Ala615Thr",
          "transcript": "ENST00000436575.5",
          "protein_id": "ENSP00000404785.1",
          "transcript_support_level": 2,
          "aa_start": 615,
          "aa_end": null,
          "aa_length": 631,
          "cds_start": 1843,
          "cds_end": null,
          "cds_length": 1896,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000436575.5"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.1843G>A",
          "hgvs_p": "p.Ala615Thr",
          "transcript": "ENST00000878461.1",
          "protein_id": "ENSP00000548520.1",
          "transcript_support_level": null,
          "aa_start": 615,
          "aa_end": null,
          "aa_length": 631,
          "cds_start": 1843,
          "cds_end": null,
          "cds_length": 1896,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000878461.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.1804G>A",
          "hgvs_p": "p.Ala602Thr",
          "transcript": "ENST00000878459.1",
          "protein_id": "ENSP00000548518.1",
          "transcript_support_level": null,
          "aa_start": 602,
          "aa_end": null,
          "aa_length": 618,
          "cds_start": 1804,
          "cds_end": null,
          "cds_length": 1857,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000878459.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.1762G>A",
          "hgvs_p": "p.Ala588Thr",
          "transcript": "ENST00000878462.1",
          "protein_id": "ENSP00000548521.1",
          "transcript_support_level": null,
          "aa_start": 588,
          "aa_end": null,
          "aa_length": 604,
          "cds_start": 1762,
          "cds_end": null,
          "cds_length": 1815,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000878462.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.1711G>A",
          "hgvs_p": "p.Ala571Thr",
          "transcript": "ENST00000878458.1",
          "protein_id": "ENSP00000548517.1",
          "transcript_support_level": null,
          "aa_start": 571,
          "aa_end": null,
          "aa_length": 587,
          "cds_start": 1711,
          "cds_end": null,
          "cds_length": 1764,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000878458.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.1702G>A",
          "hgvs_p": "p.Ala568Thr",
          "transcript": "ENST00000930345.1",
          "protein_id": "ENSP00000600404.1",
          "transcript_support_level": null,
          "aa_start": 568,
          "aa_end": null,
          "aa_length": 584,
          "cds_start": 1702,
          "cds_end": null,
          "cds_length": 1755,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000930345.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.1672G>A",
          "hgvs_p": "p.Ala558Thr",
          "transcript": "ENST00000878460.1",
          "protein_id": "ENSP00000548519.1",
          "transcript_support_level": null,
          "aa_start": 558,
          "aa_end": null,
          "aa_length": 574,
          "cds_start": 1672,
          "cds_end": null,
          "cds_length": 1725,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000878460.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.1666G>A",
          "hgvs_p": "p.Ala556Thr",
          "transcript": "ENST00000947925.1",
          "protein_id": "ENSP00000617984.1",
          "transcript_support_level": null,
          "aa_start": 556,
          "aa_end": null,
          "aa_length": 572,
          "cds_start": 1666,
          "cds_end": null,
          "cds_length": 1719,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000947925.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.1627G>A",
          "hgvs_p": "p.Ala543Thr",
          "transcript": "ENST00000930344.1",
          "protein_id": "ENSP00000600403.1",
          "transcript_support_level": null,
          "aa_start": 543,
          "aa_end": null,
          "aa_length": 559,
          "cds_start": 1627,
          "cds_end": null,
          "cds_length": 1680,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000930344.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.1579G>A",
          "hgvs_p": "p.Ala527Thr",
          "transcript": "NM_001142936.2",
          "protein_id": "NP_001136408.1",
          "transcript_support_level": null,
          "aa_start": 527,
          "aa_end": null,
          "aa_length": 543,
          "cds_start": 1579,
          "cds_end": null,
          "cds_length": 1632,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001142936.2"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.1579G>A",
          "hgvs_p": "p.Ala527Thr",
          "transcript": "ENST00000425398.6",
          "protein_id": "ENSP00000391171.2",
          "transcript_support_level": 2,
          "aa_start": 527,
          "aa_end": null,
          "aa_length": 543,
          "cds_start": 1579,
          "cds_end": null,
          "cds_length": 1632,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000425398.6"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.1549G>A",
          "hgvs_p": "p.Ala517Thr",
          "transcript": "ENST00000930343.1",
          "protein_id": "ENSP00000600402.1",
          "transcript_support_level": null,
          "aa_start": 517,
          "aa_end": null,
          "aa_length": 533,
          "cds_start": 1549,
          "cds_end": null,
          "cds_length": 1602,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000930343.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.1531G>A",
          "hgvs_p": "p.Ala511Thr",
          "transcript": "ENST00000930346.1",
          "protein_id": "ENSP00000600405.1",
          "transcript_support_level": null,
          "aa_start": 511,
          "aa_end": null,
          "aa_length": 527,
          "cds_start": 1531,
          "cds_end": null,
          "cds_length": 1584,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000930346.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.1507G>A",
          "hgvs_p": "p.Ala503Thr",
          "transcript": "ENST00000947926.1",
          "protein_id": "ENSP00000617985.1",
          "transcript_support_level": null,
          "aa_start": 503,
          "aa_end": null,
          "aa_length": 519,
          "cds_start": 1507,
          "cds_end": null,
          "cds_length": 1560,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000947926.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "c.1210G>A",
          "hgvs_p": "p.Ala404Thr",
          "transcript": "ENST00000930342.1",
          "protein_id": "ENSP00000600401.1",
          "transcript_support_level": null,
          "aa_start": 404,
          "aa_end": null,
          "aa_length": 420,
          "cds_start": 1210,
          "cds_end": null,
          "cds_length": 1263,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000930342.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "n.1825G>A",
          "hgvs_p": null,
          "transcript": "ENST00000462934.5",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000462934.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DAGLB",
          "gene_hgnc_id": 28923,
          "hgvs_c": "n.1618G>A",
          "hgvs_p": null,
          "transcript": "ENST00000482149.5",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000482149.5"
        }
      ],
      "gene_symbol": "DAGLB",
      "gene_hgnc_id": 28923,
      "dbsnp": "rs145993691",
      "frequency_reference_population": 0.0010278034,
      "hom_count_reference_population": 19,
      "allele_count_reference_population": 1659,
      "gnomad_exomes_af": 0.000581484,
      "gnomad_genomes_af": 0.00531035,
      "gnomad_exomes_ac": 850,
      "gnomad_genomes_ac": 809,
      "gnomad_exomes_homalt": 11,
      "gnomad_genomes_homalt": 8,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.0029959678649902344,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.072,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.0736,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.75,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 0.004,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -14,
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BP6_Moderate,BS1,BS2",
      "acmg_by_gene": [
        {
          "score": -14,
          "benign_score": 14,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong",
            "BP6_Moderate",
            "BS1",
            "BS2"
          ],
          "verdict": "Benign",
          "transcript": "NM_139179.4",
          "gene_symbol": "DAGLB",
          "hgnc_id": 28923,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.1966G>A",
          "hgvs_p": "p.Ala656Thr"
        }
      ],
      "clinvar_disease": "not provided",
      "clinvar_classification": "Benign",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "B:1",
      "phenotype_combined": "not provided",
      "pathogenicity_classification_combined": "Benign",
      "custom_annotations": null
    }
  ],
  "message": null
}