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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 7-65975066-C-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=65975066&ref=C&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 1,
          "criteria": [
            "BP4"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "GUSB",
          "hgnc_id": 4696,
          "hgvs_c": "c.918G>T",
          "hgvs_p": "p.Gln306His",
          "inheritance_mode": "AR",
          "pathogenic_score": 0,
          "score": -1,
          "transcript": "NM_000181.4",
          "verdict": "Likely_benign"
        }
      ],
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "BP4",
      "acmg_score": -1,
      "allele_count_reference_population": 184,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.1575,
      "alt": "A",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.28,
      "chr": "7",
      "clinvar_classification": "Uncertain significance",
      "clinvar_disease": "Inborn genetic diseases,Mucopolysaccharidosis type 7",
      "clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
      "clinvar_submissions_summary": "US:2",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": 0.32298725843429565,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 651,
          "aa_ref": "Q",
          "aa_start": 306,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2199,
          "cdna_start": 948,
          "cds_end": null,
          "cds_length": 1956,
          "cds_start": 918,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "NM_000181.4",
          "gene_hgnc_id": 4696,
          "gene_symbol": "GUSB",
          "hgvs_c": "c.918G>T",
          "hgvs_p": "p.Gln306His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000304895.9",
          "protein_coding": true,
          "protein_id": "NP_000172.2",
          "strand": false,
          "transcript": "NM_000181.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 651,
          "aa_ref": "Q",
          "aa_start": 306,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 2199,
          "cdna_start": 948,
          "cds_end": null,
          "cds_length": 1956,
          "cds_start": 918,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000304895.9",
          "gene_hgnc_id": 4696,
          "gene_symbol": "GUSB",
          "hgvs_c": "c.918G>T",
          "hgvs_p": "p.Gln306His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_000181.4",
          "protein_coding": true,
          "protein_id": "ENSP00000302728.4",
          "strand": false,
          "transcript": "ENST00000304895.9",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 679,
          "aa_ref": "Q",
          "aa_start": 334,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2283,
          "cdna_start": 1032,
          "cds_end": null,
          "cds_length": 2040,
          "cds_start": 1002,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000864783.1",
          "gene_hgnc_id": 4696,
          "gene_symbol": "GUSB",
          "hgvs_c": "c.1002G>T",
          "hgvs_p": "p.Gln334His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000534842.1",
          "strand": false,
          "transcript": "ENST00000864783.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 661,
          "aa_ref": "Q",
          "aa_start": 327,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2218,
          "cdna_start": 1011,
          "cds_end": null,
          "cds_length": 1986,
          "cds_start": 981,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000864792.1",
          "gene_hgnc_id": 4696,
          "gene_symbol": "GUSB",
          "hgvs_c": "c.981G>T",
          "hgvs_p": "p.Gln327His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000534851.1",
          "strand": false,
          "transcript": "ENST00000864792.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 660,
          "aa_ref": "Q",
          "aa_start": 315,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2220,
          "cdna_start": 975,
          "cds_end": null,
          "cds_length": 1983,
          "cds_start": 945,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000864788.1",
          "gene_hgnc_id": 4696,
          "gene_symbol": "GUSB",
          "hgvs_c": "c.945G>T",
          "hgvs_p": "p.Gln315His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000534847.1",
          "strand": false,
          "transcript": "ENST00000864788.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 658,
          "aa_ref": "Q",
          "aa_start": 306,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2192,
          "cdna_start": 948,
          "cds_end": null,
          "cds_length": 1977,
          "cds_start": 918,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000912577.1",
          "gene_hgnc_id": 4696,
          "gene_symbol": "GUSB",
          "hgvs_c": "c.918G>T",
          "hgvs_p": "p.Gln306His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000582636.1",
          "strand": false,
          "transcript": "ENST00000912577.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 650,
          "aa_ref": "Q",
          "aa_start": 305,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2204,
          "cdna_start": 953,
          "cds_end": null,
          "cds_length": 1953,
          "cds_start": 915,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000864780.1",
          "gene_hgnc_id": 4696,
          "gene_symbol": "GUSB",
          "hgvs_c": "c.915G>T",
          "hgvs_p": "p.Gln305His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000534839.1",
          "strand": false,
          "transcript": "ENST00000864780.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 640,
          "aa_ref": "Q",
          "aa_start": 306,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2183,
          "cdna_start": 965,
          "cds_end": null,
          "cds_length": 1923,
          "cds_start": 918,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000864778.1",
          "gene_hgnc_id": 4696,
          "gene_symbol": "GUSB",
          "hgvs_c": "c.918G>T",
          "hgvs_p": "p.Gln306His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000534837.1",
          "strand": false,
          "transcript": "ENST00000864778.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 634,
          "aa_ref": "Q",
          "aa_start": 289,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2129,
          "cdna_start": 897,
          "cds_end": null,
          "cds_length": 1905,
          "cds_start": 867,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000864798.1",
          "gene_hgnc_id": 4696,
          "gene_symbol": "GUSB",
          "hgvs_c": "c.867G>T",
          "hgvs_p": "p.Gln289His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000534857.1",
          "strand": false,
          "transcript": "ENST00000864798.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 628,
          "aa_ref": "Q",
          "aa_start": 283,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2121,
          "cdna_start": 881,
          "cds_end": null,
          "cds_length": 1887,
          "cds_start": 849,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000864790.1",
          "gene_hgnc_id": 4696,
          "gene_symbol": "GUSB",
          "hgvs_c": "c.849G>T",
          "hgvs_p": "p.Gln283His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000534849.1",
          "strand": false,
          "transcript": "ENST00000864790.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 625,
          "aa_ref": "Q",
          "aa_start": 280,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2117,
          "cdna_start": 870,
          "cds_end": null,
          "cds_length": 1878,
          "cds_start": 840,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000864786.1",
          "gene_hgnc_id": 4696,
          "gene_symbol": "GUSB",
          "hgvs_c": "c.840G>T",
          "hgvs_p": "p.Gln280His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000534845.1",
          "strand": false,
          "transcript": "ENST00000864786.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 612,
          "aa_ref": "Q",
          "aa_start": 306,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2080,
          "cdna_start": 950,
          "cds_end": null,
          "cds_length": 1839,
          "cds_start": 918,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000864785.1",
          "gene_hgnc_id": 4696,
          "gene_symbol": "GUSB",
          "hgvs_c": "c.918G>T",
          "hgvs_p": "p.Gln306His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000534844.1",
          "strand": false,
          "transcript": "ENST00000864785.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 592,
          "aa_ref": "Q",
          "aa_start": 306,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2027,
          "cdna_start": 953,
          "cds_end": null,
          "cds_length": 1779,
          "cds_start": 918,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000864781.1",
          "gene_hgnc_id": 4696,
          "gene_symbol": "GUSB",
          "hgvs_c": "c.918G>T",
          "hgvs_p": "p.Gln306His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000534840.1",
          "strand": false,
          "transcript": "ENST00000864781.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 568,
          "aa_ref": "Q",
          "aa_start": 223,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1933,
          "cdna_start": 699,
          "cds_end": null,
          "cds_length": 1707,
          "cds_start": 669,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000864796.1",
          "gene_hgnc_id": 4696,
          "gene_symbol": "GUSB",
          "hgvs_c": "c.669G>T",
          "hgvs_p": "p.Gln223His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000534855.1",
          "strand": false,
          "transcript": "ENST00000864796.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 550,
          "aa_ref": "Q",
          "aa_start": 205,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1882,
          "cdna_start": 645,
          "cds_end": null,
          "cds_length": 1653,
          "cds_start": 615,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000864793.1",
          "gene_hgnc_id": 4696,
          "gene_symbol": "GUSB",
          "hgvs_c": "c.615G>T",
          "hgvs_p": "p.Gln205His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000534852.1",
          "strand": false,
          "transcript": "ENST00000864793.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 505,
          "aa_ref": "Q",
          "aa_start": 160,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1761,
          "cdna_start": 510,
          "cds_end": null,
          "cds_length": 1518,
          "cds_start": 480,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "NM_001284290.2",
          "gene_hgnc_id": 4696,
          "gene_symbol": "GUSB",
          "hgvs_c": "c.480G>T",
          "hgvs_p": "p.Gln160His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001271219.1",
          "strand": false,
          "transcript": "NM_001284290.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 505,
          "aa_ref": "Q",
          "aa_start": 160,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1742,
          "cdna_start": 508,
          "cds_end": null,
          "cds_length": 1518,
          "cds_start": 480,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000421103.5",
          "gene_hgnc_id": 4696,
          "gene_symbol": "GUSB",
          "hgvs_c": "c.480G>T",
          "hgvs_p": "p.Gln160His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000391390.1",
          "strand": false,
          "transcript": "ENST00000421103.5",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 461,
          "aa_ref": "Q",
          "aa_start": 116,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2014,
          "cdna_start": 763,
          "cds_end": null,
          "cds_length": 1386,
          "cds_start": 348,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "NM_001293104.2",
          "gene_hgnc_id": 4696,
          "gene_symbol": "GUSB",
          "hgvs_c": "c.348G>T",
          "hgvs_p": "p.Gln116His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001280033.1",
          "strand": false,
          "transcript": "NM_001293104.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 432,
          "aa_ref": "Q",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1871,
          "cdna_start": 620,
          "cds_end": null,
          "cds_length": 1299,
          "cds_start": 261,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "NM_001293105.2",
          "gene_hgnc_id": 4696,
          "gene_symbol": "GUSB",
          "hgvs_c": "c.261G>T",
          "hgvs_p": "p.Gln87His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.