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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 7-67234797-T-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=67234797&ref=T&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "7",
      "pos": 67234797,
      "ref": "T",
      "alt": "C",
      "effect": "intron_variant",
      "transcript": "NM_018264.4",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": 15,
          "intron_rank_end": null,
          "gene_symbol": "TYW1",
          "gene_hgnc_id": 25598,
          "hgvs_c": "c.1978-3511T>C",
          "hgvs_p": null,
          "transcript": "NM_018264.4",
          "protein_id": "NP_060734.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 732,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2199,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000359626.10",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_018264.4"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": 15,
          "intron_rank_end": null,
          "gene_symbol": "TYW1",
          "gene_hgnc_id": 25598,
          "hgvs_c": "c.1978-3511T>C",
          "hgvs_p": null,
          "transcript": "ENST00000359626.10",
          "protein_id": "ENSP00000352645.5",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 732,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2199,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_018264.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000359626.10"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": 14,
          "intron_rank_end": null,
          "gene_symbol": "TYW1",
          "gene_hgnc_id": 25598,
          "hgvs_c": "n.*770-3511T>C",
          "hgvs_p": null,
          "transcript": "ENST00000361660.8",
          "protein_id": "ENSP00000354795.4",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000361660.8"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": 16,
          "intron_rank_end": null,
          "gene_symbol": "TYW1",
          "gene_hgnc_id": 25598,
          "hgvs_c": "c.2152-3511T>C",
          "hgvs_p": null,
          "transcript": "ENST00000860521.1",
          "protein_id": "ENSP00000530580.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 790,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2373,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000860521.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": 16,
          "intron_rank_end": null,
          "gene_symbol": "TYW1",
          "gene_hgnc_id": 25598,
          "hgvs_c": "c.2020-3511T>C",
          "hgvs_p": null,
          "transcript": "ENST00000935197.1",
          "protein_id": "ENSP00000605256.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 746,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2241,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000935197.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": 15,
          "intron_rank_end": null,
          "gene_symbol": "TYW1",
          "gene_hgnc_id": 25598,
          "hgvs_c": "c.2008-3511T>C",
          "hgvs_p": null,
          "transcript": "ENST00000860522.1",
          "protein_id": "ENSP00000530581.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 742,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2229,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000860522.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": 15,
          "intron_rank_end": null,
          "gene_symbol": "TYW1",
          "gene_hgnc_id": 25598,
          "hgvs_c": "c.2005-3511T>C",
          "hgvs_p": null,
          "transcript": "ENST00000960946.1",
          "protein_id": "ENSP00000631005.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 741,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2226,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000960946.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": 15,
          "intron_rank_end": null,
          "gene_symbol": "TYW1",
          "gene_hgnc_id": 25598,
          "hgvs_c": "c.1975-3511T>C",
          "hgvs_p": null,
          "transcript": "ENST00000935194.1",
          "protein_id": "ENSP00000605253.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 731,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2196,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000935194.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": 15,
          "intron_rank_end": null,
          "gene_symbol": "TYW1",
          "gene_hgnc_id": 25598,
          "hgvs_c": "c.1966-3511T>C",
          "hgvs_p": null,
          "transcript": "ENST00000935196.1",
          "protein_id": "ENSP00000605255.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": 728,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2187,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000935196.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 15,
          "intron_rank": 14,
          "intron_rank_end": null,
          "gene_symbol": "TYW1",
          "gene_hgnc_id": 25598,
          "hgvs_c": "c.1867-3511T>C",
          "hgvs_p": null,
          "transcript": "ENST00000960945.1",
          "protein_id": "ENSP00000631004.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": 695,
          "cds_start": null,
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          "cdna_start": null,
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          "biotype": "protein_coding",
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        {
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          "canonical": false,
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          "intron_rank": 14,
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          "gene_symbol": "TYW1",
          "gene_hgnc_id": 25598,
          "hgvs_c": "c.1855-3511T>C",
          "hgvs_p": null,
          "transcript": "ENST00000960949.1",
          "protein_id": "ENSP00000631008.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": 691,
          "cds_start": null,
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          "cdna_start": null,
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          "biotype": "protein_coding",
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        {
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        {
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          "gene_symbol": "TYW1",
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          "protein_id": "ENSP00000530579.1",
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        {
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          "exon_count": 14,
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          "gene_symbol": "TYW1",
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          "protein_id": "ENSP00000631006.1",
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        {
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          "exon_count": 13,
          "intron_rank": 12,
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          "gene_symbol": "TYW1",
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          "transcript": "XM_017012392.3",
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        {
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          "gene_symbol": "TYW1",
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          "hgvs_c": "n.970-3511T>C",
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          "transcript": "ENST00000495971.1",
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        {
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        {
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          "gene_symbol": "ENSG00000291154",
          "gene_hgnc_id": null,
          "hgvs_c": "n.1037-41638A>G",
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          "transcript": "ENST00000685318.2",
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        },
        {
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          "consequences": [
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          ],
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      "gnomad_genomes_af": 0.386043,
      "gnomad_exomes_ac": null,
      "gnomad_genomes_ac": 58640,
      "gnomad_exomes_homalt": null,
      "gnomad_genomes_homalt": 12177,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": -0.9800000190734863,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "BayesDel_noAF",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.98,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": -1.182,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -12,
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BA1",
      "acmg_by_gene": [
        {
          "score": -12,
          "benign_score": 12,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong",
            "BA1"
          ],
          "verdict": "Benign",
          "transcript": "NM_018264.4",
          "gene_symbol": "TYW1",
          "hgnc_id": 25598,
          "effects": [
            "intron_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.1978-3511T>C",
          "hgvs_p": null
        },
        {
          "score": -12,
          "benign_score": 12,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong",
            "BA1"
          ],
          "verdict": "Benign",
          "transcript": "ENST00000684859.2",
          "gene_symbol": "ENSG00000291154",
          "hgnc_id": null,
          "effects": [
            "intron_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.521-41638A>G",
          "hgvs_p": null
        },
        {
          "score": -12,
          "benign_score": 12,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong",
            "BA1"
          ],
          "verdict": "Benign",
          "transcript": "XR_007060371.1",
          "gene_symbol": "LOC124901665",
          "hgnc_id": null,
          "effects": [
            "intron_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.719+1437A>G",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}
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