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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 7-87935182-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=87935182&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "7",
"pos": 87935182,
"ref": "C",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_001324418.2",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.242C>A",
"hgvs_p": "p.Pro81Gln",
"transcript": "NM_001324418.2",
"protein_id": "NP_001311347.1",
"transcript_support_level": null,
"aa_start": 81,
"aa_end": null,
"aa_length": 964,
"cds_start": 242,
"cds_end": null,
"cds_length": 2895,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000413139.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001324418.2"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.242C>A",
"hgvs_p": "p.Pro81Gln",
"transcript": "ENST00000413139.2",
"protein_id": "ENSP00000412085.2",
"transcript_support_level": 5,
"aa_start": 81,
"aa_end": null,
"aa_length": 964,
"cds_start": 242,
"cds_end": null,
"cds_length": 2895,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001324418.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000413139.2"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.242C>A",
"hgvs_p": "p.Pro81Gln",
"transcript": "ENST00000265727.11",
"protein_id": "ENSP00000265727.7",
"transcript_support_level": 1,
"aa_start": 81,
"aa_end": null,
"aa_length": 906,
"cds_start": 242,
"cds_end": null,
"cds_length": 2721,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000265727.11"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.242C>A",
"hgvs_p": "p.Pro81Gln",
"transcript": "ENST00000398209.7",
"protein_id": "ENSP00000381267.3",
"transcript_support_level": 1,
"aa_start": 81,
"aa_end": null,
"aa_length": 899,
"cds_start": 242,
"cds_end": null,
"cds_length": 2700,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000398209.7"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.242C>A",
"hgvs_p": "p.Pro81Gln",
"transcript": "ENST00000398204.8",
"protein_id": "ENSP00000381262.4",
"transcript_support_level": 1,
"aa_start": 81,
"aa_end": null,
"aa_length": 870,
"cds_start": 242,
"cds_end": null,
"cds_length": 2613,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000398204.8"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.242C>A",
"hgvs_p": "p.Pro81Gln",
"transcript": "ENST00000398201.8",
"protein_id": "ENSP00000381260.4",
"transcript_support_level": 1,
"aa_start": 81,
"aa_end": null,
"aa_length": 859,
"cds_start": 242,
"cds_end": null,
"cds_length": 2580,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000398201.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "n.457C>A",
"hgvs_p": null,
"transcript": "ENST00000439864.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000439864.5"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.239C>A",
"hgvs_p": "p.Pro80Gln",
"transcript": "NM_001324419.2",
"protein_id": "NP_001311348.1",
"transcript_support_level": null,
"aa_start": 80,
"aa_end": null,
"aa_length": 963,
"cds_start": 239,
"cds_end": null,
"cds_length": 2892,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001324419.2"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.239C>A",
"hgvs_p": "p.Pro80Gln",
"transcript": "ENST00000966491.1",
"protein_id": "ENSP00000636550.1",
"transcript_support_level": null,
"aa_start": 80,
"aa_end": null,
"aa_length": 963,
"cds_start": 239,
"cds_end": null,
"cds_length": 2892,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000966491.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.242C>A",
"hgvs_p": "p.Pro81Gln",
"transcript": "NM_001391975.1",
"protein_id": "NP_001378904.1",
"transcript_support_level": null,
"aa_start": 81,
"aa_end": null,
"aa_length": 953,
"cds_start": 242,
"cds_end": null,
"cds_length": 2862,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001391975.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.242C>A",
"hgvs_p": "p.Pro81Gln",
"transcript": "NM_001391976.1",
"protein_id": "NP_001378905.1",
"transcript_support_level": null,
"aa_start": 81,
"aa_end": null,
"aa_length": 943,
"cds_start": 242,
"cds_end": null,
"cds_length": 2832,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001391976.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.242C>A",
"hgvs_p": "p.Pro81Gln",
"transcript": "ENST00000915159.1",
"protein_id": "ENSP00000585218.1",
"transcript_support_level": null,
"aa_start": 81,
"aa_end": null,
"aa_length": 936,
"cds_start": 242,
"cds_end": null,
"cds_length": 2811,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000915159.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.242C>A",
"hgvs_p": "p.Pro81Gln",
"transcript": "NM_001324420.2",
"protein_id": "NP_001311349.1",
"transcript_support_level": null,
"aa_start": 81,
"aa_end": null,
"aa_length": 935,
"cds_start": 242,
"cds_end": null,
"cds_length": 2808,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001324420.2"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.242C>A",
"hgvs_p": "p.Pro81Gln",
"transcript": "ENST00000898403.1",
"protein_id": "ENSP00000568462.1",
"transcript_support_level": null,
"aa_start": 81,
"aa_end": null,
"aa_length": 935,
"cds_start": 242,
"cds_end": null,
"cds_length": 2808,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898403.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.242C>A",
"hgvs_p": "p.Pro81Gln",
"transcript": "ENST00000898404.1",
"protein_id": "ENSP00000568463.1",
"transcript_support_level": null,
"aa_start": 81,
"aa_end": null,
"aa_length": 916,
"cds_start": 242,
"cds_end": null,
"cds_length": 2751,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898404.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.242C>A",
"hgvs_p": "p.Pro81Gln",
"transcript": "ENST00000915161.1",
"protein_id": "ENSP00000585220.1",
"transcript_support_level": null,
"aa_start": 81,
"aa_end": null,
"aa_length": 909,
"cds_start": 242,
"cds_end": null,
"cds_length": 2730,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000915161.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.242C>A",
"hgvs_p": "p.Pro81Gln",
"transcript": "NM_001391977.1",
"protein_id": "NP_001378906.1",
"transcript_support_level": null,
"aa_start": 81,
"aa_end": null,
"aa_length": 907,
"cds_start": 242,
"cds_end": null,
"cds_length": 2724,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001391977.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.242C>A",
"hgvs_p": "p.Pro81Gln",
"transcript": "ENST00000915160.1",
"protein_id": "ENSP00000585219.1",
"transcript_support_level": null,
"aa_start": 81,
"aa_end": null,
"aa_length": 907,
"cds_start": 242,
"cds_end": null,
"cds_length": 2724,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000915160.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.239C>A",
"hgvs_p": "p.Pro80Gln",
"transcript": "NM_001391978.1",
"protein_id": "NP_001378907.1",
"transcript_support_level": null,
"aa_start": 80,
"aa_end": null,
"aa_length": 906,
"cds_start": 239,
"cds_end": null,
"cds_length": 2721,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001391978.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.242C>A",
"hgvs_p": "p.Pro81Gln",
"transcript": "NM_021723.5",
"protein_id": "NP_068369.1",
"transcript_support_level": null,
"aa_start": 81,
"aa_end": null,
"aa_length": 906,
"cds_start": 242,
"cds_end": null,
"cds_length": 2721,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_021723.5"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.242C>A",
"hgvs_p": "p.Pro81Gln",
"transcript": "ENST00000683525.1",
"protein_id": "ENSP00000506730.1",
"transcript_support_level": null,
"aa_start": 81,
"aa_end": null,
"aa_length": 905,
"cds_start": 242,
"cds_end": null,
"cds_length": 2720,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000683525.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.239C>A",
"hgvs_p": "p.Pro80Gln",
"transcript": "NM_001391979.1",
"protein_id": "NP_001378908.1",
"transcript_support_level": null,
"aa_start": 80,
"aa_end": null,
"aa_length": 905,
"cds_start": 239,
"cds_end": null,
"cds_length": 2718,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001391979.1"
},
{
"aa_ref": "P",
"aa_alt": "Q",
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}
],
"message": null
}