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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 7-88125600-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=88125600&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "7",
"pos": 88125600,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "ENST00000413139.2",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "NM_001324418.2",
"protein_id": "NP_001311347.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 964,
"cds_start": 619,
"cds_end": null,
"cds_length": 2895,
"cdna_start": 834,
"cdna_end": null,
"cdna_length": 9508,
"mane_select": "ENST00000413139.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "ENST00000413139.2",
"protein_id": "ENSP00000412085.2",
"transcript_support_level": 5,
"aa_start": 207,
"aa_end": null,
"aa_length": 964,
"cds_start": 619,
"cds_end": null,
"cds_length": 2895,
"cdna_start": 834,
"cdna_end": null,
"cdna_length": 9508,
"mane_select": "NM_001324418.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "ENST00000265727.11",
"protein_id": "ENSP00000265727.7",
"transcript_support_level": 1,
"aa_start": 207,
"aa_end": null,
"aa_length": 906,
"cds_start": 619,
"cds_end": null,
"cds_length": 2721,
"cdna_start": 698,
"cdna_end": null,
"cdna_length": 2891,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "ENST00000398209.7",
"protein_id": "ENSP00000381267.3",
"transcript_support_level": 1,
"aa_start": 207,
"aa_end": null,
"aa_length": 899,
"cds_start": 619,
"cds_end": null,
"cds_length": 2700,
"cdna_start": 665,
"cdna_end": null,
"cdna_length": 9144,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "ENST00000398204.8",
"protein_id": "ENSP00000381262.4",
"transcript_support_level": 1,
"aa_start": 207,
"aa_end": null,
"aa_length": 870,
"cds_start": 619,
"cds_end": null,
"cds_length": 2613,
"cdna_start": 942,
"cdna_end": null,
"cdna_length": 9334,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "ENST00000398201.8",
"protein_id": "ENSP00000381260.4",
"transcript_support_level": 1,
"aa_start": 207,
"aa_end": null,
"aa_length": 859,
"cds_start": 619,
"cds_end": null,
"cds_length": 2580,
"cdna_start": 738,
"cdna_end": null,
"cdna_length": 2784,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "n.834G>A",
"hgvs_p": null,
"transcript": "ENST00000439864.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2576,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.616G>A",
"hgvs_p": "p.Val206Ile",
"transcript": "NM_001324419.2",
"protein_id": "NP_001311348.1",
"transcript_support_level": null,
"aa_start": 206,
"aa_end": null,
"aa_length": 963,
"cds_start": 616,
"cds_end": null,
"cds_length": 2892,
"cdna_start": 831,
"cdna_end": null,
"cdna_length": 9505,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.670G>A",
"hgvs_p": "p.Val224Ile",
"transcript": "NM_001391975.1",
"protein_id": "NP_001378904.1",
"transcript_support_level": null,
"aa_start": 224,
"aa_end": null,
"aa_length": 953,
"cds_start": 670,
"cds_end": null,
"cds_length": 2862,
"cdna_start": 885,
"cdna_end": null,
"cdna_length": 9475,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "NM_001391976.1",
"protein_id": "NP_001378905.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 943,
"cds_start": 619,
"cds_end": null,
"cds_length": 2832,
"cdna_start": 834,
"cdna_end": null,
"cdna_length": 9445,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "NM_001324420.2",
"protein_id": "NP_001311349.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 935,
"cds_start": 619,
"cds_end": null,
"cds_length": 2808,
"cdna_start": 834,
"cdna_end": null,
"cdna_length": 9421,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "NM_001391977.1",
"protein_id": "NP_001378906.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 907,
"cds_start": 619,
"cds_end": null,
"cds_length": 2724,
"cdna_start": 834,
"cdna_end": null,
"cdna_length": 9337,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.616G>A",
"hgvs_p": "p.Val206Ile",
"transcript": "NM_001391978.1",
"protein_id": "NP_001378907.1",
"transcript_support_level": null,
"aa_start": 206,
"aa_end": null,
"aa_length": 906,
"cds_start": 616,
"cds_end": null,
"cds_length": 2721,
"cdna_start": 831,
"cdna_end": null,
"cdna_length": 9334,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "NM_021723.5",
"protein_id": "NP_068369.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 906,
"cds_start": 619,
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"cdna_start": 834,
"cdna_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "ENST00000683525.1",
"protein_id": "ENSP00000506730.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 905,
"cds_start": 619,
"cds_end": null,
"cds_length": 2720,
"cdna_start": 756,
"cdna_end": null,
"cdna_length": 2857,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.616G>A",
"hgvs_p": "p.Val206Ile",
"transcript": "NM_001391979.1",
"protein_id": "NP_001378908.1",
"transcript_support_level": null,
"aa_start": 206,
"aa_end": null,
"aa_length": 905,
"cds_start": 616,
"cds_end": null,
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"cdna_start": 831,
"cdna_end": null,
"cdna_length": 9331,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "NM_021722.6",
"protein_id": "NP_068368.2",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 899,
"cds_start": 619,
"cds_end": null,
"cds_length": 2700,
"cdna_start": 834,
"cdna_end": null,
"cdna_length": 9313,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "NM_001324421.2",
"protein_id": "NP_001311350.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 890,
"cds_start": 619,
"cds_end": null,
"cds_length": 2673,
"cdna_start": 834,
"cdna_end": null,
"cdna_length": 9102,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.670G>A",
"hgvs_p": "p.Val224Ile",
"transcript": "NM_001391980.1",
"protein_id": "NP_001378909.1",
"transcript_support_level": null,
"aa_start": 224,
"aa_end": null,
"aa_length": 887,
"cds_start": 670,
"cds_end": null,
"cds_length": 2664,
"cdna_start": 885,
"cdna_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "NM_016351.6",
"protein_id": "NP_057435.2",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 870,
"cds_start": 619,
"cds_end": null,
"cds_length": 2613,
"cdna_start": 834,
"cdna_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.616G>A",
"hgvs_p": "p.Val206Ile",
"transcript": "NM_001324417.2",
"protein_id": "NP_001311346.1",
"transcript_support_level": null,
"aa_start": 206,
"aa_end": null,
"aa_length": 869,
"cds_start": 616,
"cds_end": null,
"cds_length": 2610,
"cdna_start": 831,
"cdna_end": null,
"cdna_length": 9223,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.616G>A",
"hgvs_p": "p.Val206Ile",
"transcript": "NM_001391981.1",
"protein_id": "NP_001378910.1",
"transcript_support_level": null,
"aa_start": 206,
"aa_end": null,
"aa_length": 863,
"cds_start": 616,
"cds_end": null,
"cds_length": 2592,
"cdna_start": 831,
"cdna_end": null,
"cdna_length": 9205,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.670G>A",
"hgvs_p": "p.Val224Ile",
"transcript": "NM_001391982.1",
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