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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 7-90226986-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=90226986&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "7",
"pos": 90226986,
"ref": "A",
"alt": "C",
"effect": "missense_variant",
"transcript": "ENST00000394621.7",
"consequences": [
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "NM_001244944.2",
"protein_id": "NP_001231873.1",
"transcript_support_level": null,
"aa_start": 170,
"aa_end": null,
"aa_length": 490,
"cds_start": 508,
"cds_end": null,
"cds_length": 1473,
"cdna_start": 960,
"cdna_end": null,
"cdna_length": 6984,
"mane_select": "ENST00000394621.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "ENST00000394621.7",
"protein_id": "ENSP00000378119.2",
"transcript_support_level": 1,
"aa_start": 170,
"aa_end": null,
"aa_length": 490,
"cds_start": 508,
"cds_end": null,
"cds_length": 1473,
"cdna_start": 960,
"cdna_end": null,
"cdna_length": 6984,
"mane_select": "NM_001244944.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "ENST00000287908.7",
"protein_id": "ENSP00000287908.3",
"transcript_support_level": 1,
"aa_start": 170,
"aa_end": null,
"aa_length": 490,
"cds_start": 508,
"cds_end": null,
"cds_length": 1473,
"cdna_start": 901,
"cdna_end": null,
"cdna_length": 6873,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "ENST00000394622.6",
"protein_id": "ENSP00000378120.2",
"transcript_support_level": 1,
"aa_start": 170,
"aa_end": null,
"aa_length": 490,
"cds_start": 508,
"cds_end": null,
"cds_length": 1473,
"cdna_start": 677,
"cdna_end": null,
"cdna_length": 6612,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "ENST00000394629.2",
"protein_id": "ENSP00000378125.2",
"transcript_support_level": 1,
"aa_start": 170,
"aa_end": null,
"aa_length": 454,
"cds_start": 508,
"cds_end": null,
"cds_length": 1365,
"cdna_start": 695,
"cdna_end": null,
"cdna_length": 2261,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "ENST00000394632.5",
"protein_id": "ENSP00000378128.1",
"transcript_support_level": 1,
"aa_start": 170,
"aa_end": null,
"aa_length": 419,
"cds_start": 508,
"cds_end": null,
"cds_length": 1260,
"cdna_start": 677,
"cdna_end": null,
"cdna_length": 2072,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "ENST00000428074.5",
"protein_id": "ENSP00000401783.1",
"transcript_support_level": 1,
"aa_start": 170,
"aa_end": null,
"aa_length": 180,
"cds_start": 508,
"cds_end": null,
"cds_length": 545,
"cdna_start": 865,
"cdna_end": null,
"cdna_length": 902,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "n.1871A>C",
"hgvs_p": null,
"transcript": "ENST00000482369.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1918,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "NM_001040665.2",
"protein_id": "NP_001035755.1",
"transcript_support_level": null,
"aa_start": 170,
"aa_end": null,
"aa_length": 490,
"cds_start": 508,
"cds_end": null,
"cds_length": 1473,
"cdna_start": 797,
"cdna_end": null,
"cdna_length": 6821,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "NM_152999.4",
"protein_id": "NP_694544.2",
"transcript_support_level": null,
"aa_start": 170,
"aa_end": null,
"aa_length": 490,
"cds_start": 508,
"cds_end": null,
"cds_length": 1473,
"cdna_start": 847,
"cdna_end": null,
"cdna_length": 6871,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "NM_001040666.2",
"protein_id": "NP_001035756.1",
"transcript_support_level": null,
"aa_start": 170,
"aa_end": null,
"aa_length": 454,
"cds_start": 508,
"cds_end": null,
"cds_length": 1365,
"cdna_start": 695,
"cdna_end": null,
"cdna_length": 2313,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "NM_001244945.2",
"protein_id": "NP_001231874.1",
"transcript_support_level": null,
"aa_start": 170,
"aa_end": null,
"aa_length": 454,
"cds_start": 508,
"cds_end": null,
"cds_length": 1365,
"cdna_start": 847,
"cdna_end": null,
"cdna_length": 2465,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "ENST00000394626.5",
"protein_id": "ENSP00000378123.1",
"transcript_support_level": 2,
"aa_start": 170,
"aa_end": null,
"aa_length": 454,
"cds_start": 508,
"cds_end": null,
"cds_length": 1365,
"cdna_start": 843,
"cdna_end": null,
"cdna_length": 2456,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "NM_001244946.2",
"protein_id": "NP_001231875.1",
"transcript_support_level": null,
"aa_start": 170,
"aa_end": null,
"aa_length": 419,
"cds_start": 508,
"cds_end": null,
"cds_length": 1260,
"cdna_start": 797,
"cdna_end": null,
"cdna_length": 2267,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "ENST00000402625.6",
"protein_id": "ENSP00000384191.1",
"transcript_support_level": 5,
"aa_start": 170,
"aa_end": null,
"aa_length": 403,
"cds_start": 508,
"cds_end": null,
"cds_length": 1212,
"cdna_start": 656,
"cdna_end": null,
"cdna_length": 1372,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "XM_006715921.5",
"protein_id": "XP_006715984.1",
"transcript_support_level": null,
"aa_start": 170,
"aa_end": null,
"aa_length": 490,
"cds_start": 508,
"cds_end": null,
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"cdna_start": 1019,
"cdna_end": null,
"cdna_length": 7043,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "XM_017011953.3",
"protein_id": "XP_016867442.1",
"transcript_support_level": null,
"aa_start": 170,
"aa_end": null,
"aa_length": 490,
"cds_start": 508,
"cds_end": null,
"cds_length": 1473,
"cdna_start": 849,
"cdna_end": null,
"cdna_length": 6873,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "XM_017011954.3",
"protein_id": "XP_016867443.1",
"transcript_support_level": null,
"aa_start": 170,
"aa_end": null,
"aa_length": 490,
"cds_start": 508,
"cds_end": null,
"cds_length": 1473,
"cdna_start": 736,
"cdna_end": null,
"cdna_length": 6760,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "XM_047420172.1",
"protein_id": "XP_047276128.1",
"transcript_support_level": null,
"aa_start": 170,
"aa_end": null,
"aa_length": 490,
"cds_start": 508,
"cds_end": null,
"cds_length": 1473,
"cdna_start": 1080,
"cdna_end": null,
"cdna_length": 7104,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "XM_047420173.1",
"protein_id": "XP_047276129.1",
"transcript_support_level": null,
"aa_start": 170,
"aa_end": null,
"aa_length": 490,
"cds_start": 508,
"cds_end": null,
"cds_length": 1473,
"cdna_start": 908,
"cdna_end": null,
"cdna_length": 6932,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "XM_047420174.1",
"protein_id": "XP_047276130.1",
"transcript_support_level": null,
"aa_start": 170,
"aa_end": null,
"aa_length": 490,
"cds_start": 508,
"cds_end": null,
"cds_length": 1473,
"cdna_start": 890,
"cdna_end": null,
"cdna_length": 6914,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "XM_047420175.1",
"protein_id": "XP_047276131.1",
"transcript_support_level": null,
"aa_start": 170,
"aa_end": null,
"aa_length": 490,
"cds_start": 508,
"cds_end": null,
"cds_length": 1473,
"cdna_start": 1021,
"cdna_end": null,
"cdna_length": 7045,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STEAP2",
"gene_hgnc_id": 17885,
"hgvs_c": "c.508A>C",
"hgvs_p": "p.Asn170His",
"transcript": "XM_017011955.2",
"protein_id": "XP_016867444.1",
"transcript_support_level": null,
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}