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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 7-92022864-A-AAAC (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=92022864&ref=A&alt=AAAC&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "7",
      "pos": 92022864,
      "ref": "A",
      "alt": "AAAC",
      "effect": "disruptive_inframe_insertion",
      "transcript": "ENST00000356239.8",
      "consequences": [
        {
          "aa_ref": "L",
          "aa_alt": "QL",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 50,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "c.4004_4006dupAAC",
          "hgvs_p": "p.Lys1335_Leu1336insGln",
          "transcript": "NM_005751.5",
          "protein_id": "NP_005742.4",
          "transcript_support_level": null,
          "aa_start": 1336,
          "aa_end": null,
          "aa_length": 3907,
          "cds_start": 4007,
          "cds_end": null,
          "cds_length": 11724,
          "cdna_start": 4245,
          "cdna_end": null,
          "cdna_length": 12476,
          "mane_select": "ENST00000356239.8",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
          "aa_alt": "QL",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 50,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "c.4004_4006dupAAC",
          "hgvs_p": "p.Lys1335_Leu1336insGln",
          "transcript": "ENST00000356239.8",
          "protein_id": "ENSP00000348573.3",
          "transcript_support_level": 1,
          "aa_start": 1336,
          "aa_end": null,
          "aa_length": 3907,
          "cds_start": 4007,
          "cds_end": null,
          "cds_length": 11724,
          "cdna_start": 4245,
          "cdna_end": null,
          "cdna_length": 12476,
          "mane_select": "NM_005751.5",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
          "aa_alt": "QL",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 51,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "c.4004_4006dupAAC",
          "hgvs_p": "p.Lys1335_Leu1336insGln",
          "transcript": "ENST00000359028.7",
          "protein_id": "ENSP00000351922.4",
          "transcript_support_level": 5,
          "aa_start": 1336,
          "aa_end": null,
          "aa_length": 3931,
          "cds_start": 4007,
          "cds_end": null,
          "cds_length": 11796,
          "cdna_start": 4007,
          "cdna_end": null,
          "cdna_length": 12219,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
          "aa_alt": "QL",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 49,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "c.4004_4006dupAAC",
          "hgvs_p": "p.Lys1335_Leu1336insGln",
          "transcript": "ENST00000681412.1",
          "protein_id": "ENSP00000506486.1",
          "transcript_support_level": null,
          "aa_start": 1336,
          "aa_end": null,
          "aa_length": 3923,
          "cds_start": 4007,
          "cds_end": null,
          "cds_length": 11772,
          "cdna_start": 4229,
          "cdna_end": null,
          "cdna_length": 13915,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
          "aa_alt": "QL",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 51,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "c.4004_4006dupAAC",
          "hgvs_p": "p.Lys1335_Leu1336insGln",
          "transcript": "ENST00000680534.1",
          "protein_id": "ENSP00000506674.1",
          "transcript_support_level": null,
          "aa_start": 1336,
          "aa_end": null,
          "aa_length": 3920,
          "cds_start": 4007,
          "cds_end": null,
          "cds_length": 11763,
          "cdna_start": 4267,
          "cdna_end": null,
          "cdna_length": 12537,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
          "aa_alt": "QL",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 49,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "c.4004_4006dupAAC",
          "hgvs_p": "p.Lys1335_Leu1336insGln",
          "transcript": "ENST00000681722.1",
          "protein_id": "ENSP00000506566.1",
          "transcript_support_level": null,
          "aa_start": 1336,
          "aa_end": null,
          "aa_length": 3915,
          "cds_start": 4007,
          "cds_end": null,
          "cds_length": 11748,
          "cdna_start": 4245,
          "cdna_end": null,
          "cdna_length": 12328,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
          "aa_alt": "QL",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 50,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "c.4004_4006dupAAC",
          "hgvs_p": "p.Lys1335_Leu1336insGln",
          "transcript": "NM_147185.3",
          "protein_id": "NP_671714.1",
          "transcript_support_level": null,
          "aa_start": 1336,
          "aa_end": null,
          "aa_length": 3899,
          "cds_start": 4007,
          "cds_end": null,
          "cds_length": 11700,
          "cdna_start": 4245,
          "cdna_end": null,
          "cdna_length": 12452,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
          "aa_alt": "QL",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 50,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "c.4004_4006dupAAC",
          "hgvs_p": "p.Lys1335_Leu1336insGln",
          "transcript": "ENST00000680766.1",
          "protein_id": "ENSP00000505204.1",
          "transcript_support_level": null,
          "aa_start": 1336,
          "aa_end": null,
          "aa_length": 3899,
          "cds_start": 4007,
          "cds_end": null,
          "cds_length": 11700,
          "cdna_start": 4229,
          "cdna_end": null,
          "cdna_length": 12423,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
          "aa_alt": "QL",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 49,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "c.3950_3952dupAAC",
          "hgvs_p": "p.Lys1317_Leu1318insGln",
          "transcript": "ENST00000679521.1",
          "protein_id": "ENSP00000505456.1",
          "transcript_support_level": null,
          "aa_start": 1318,
          "aa_end": null,
          "aa_length": 3889,
          "cds_start": 3953,
          "cds_end": null,
          "cds_length": 11670,
          "cdna_start": 4191,
          "cdna_end": null,
          "cdna_length": 12422,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
          "aa_alt": "QL",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 49,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "c.4004_4006dupAAC",
          "hgvs_p": "p.Lys1335_Leu1336insGln",
          "transcript": "ENST00000680181.1",
          "protein_id": "ENSP00000505548.1",
          "transcript_support_level": null,
          "aa_start": 1336,
          "aa_end": null,
          "aa_length": 3876,
          "cds_start": 4007,
          "cds_end": null,
          "cds_length": 11631,
          "cdna_start": 4245,
          "cdna_end": null,
          "cdna_length": 12370,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
          "aa_alt": "QL",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 49,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "c.4004_4006dupAAC",
          "hgvs_p": "p.Lys1335_Leu1336insGln",
          "transcript": "ENST00000680513.1",
          "protein_id": "ENSP00000505284.1",
          "transcript_support_level": null,
          "aa_start": 1336,
          "aa_end": null,
          "aa_length": 3860,
          "cds_start": 4007,
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          "cds_length": 11583,
          "cdna_start": 4267,
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          "cdna_length": 12357,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 49,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "c.4004_4006dupAAC",
          "hgvs_p": "p.Lys1335_Leu1336insGln",
          "transcript": "ENST00000680072.1",
          "protein_id": "ENSP00000506581.1",
          "transcript_support_level": null,
          "aa_start": 1336,
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          "aa_length": 3848,
          "cds_start": 4007,
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          "cdna_start": 4267,
          "cdna_end": null,
          "cdna_length": 12321,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
          "aa_alt": "QL",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 48,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "c.4004_4006dupAAC",
          "hgvs_p": "p.Lys1335_Leu1336insGln",
          "transcript": "ENST00000680952.1",
          "protein_id": "ENSP00000506407.1",
          "transcript_support_level": null,
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          "aa_length": 3827,
          "cds_start": 4007,
          "cds_end": null,
          "cds_length": 11484,
          "cdna_start": 4229,
          "cdna_end": null,
          "cdna_length": 12118,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
          "aa_alt": "QL",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 49,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "c.3746_3748dupAAC",
          "hgvs_p": "p.Lys1249_Leu1250insGln",
          "transcript": "ENST00000679821.1",
          "protein_id": "ENSP00000506040.1",
          "transcript_support_level": null,
          "aa_start": 1250,
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          "cds_start": 3749,
          "cds_end": null,
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          "cdna_start": 3989,
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          "mane_select": null,
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        },
        {
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "n.4224_4226dupAAC",
          "hgvs_p": null,
          "transcript": "ENST00000493453.1",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 6020,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 34,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "n.*3733_*3735dupAAC",
          "hgvs_p": null,
          "transcript": "ENST00000674381.2",
          "protein_id": "ENSP00000501536.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 8366,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 51,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "n.4004_4006dupAAC",
          "hgvs_p": null,
          "transcript": "ENST00000679448.1",
          "protein_id": "ENSP00000505889.1",
          "transcript_support_level": null,
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          "cdna_length": 12677,
          "mane_select": null,
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        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 48,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "n.4004_4006dupAAC",
          "hgvs_p": null,
          "transcript": "ENST00000679457.1",
          "protein_id": "ENSP00000505450.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
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          "cdna_start": null,
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          "cdna_length": 13676,
          "mane_select": null,
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          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 49,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "n.4226_4228dupAAC",
          "hgvs_p": null,
          "transcript": "ENST00000679474.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 13320,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 34,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "n.*3789_*3791dupAAC",
          "hgvs_p": null,
          "transcript": "ENST00000679554.1",
          "protein_id": "ENSP00000506415.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
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        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 37,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "n.4226_4228dupAAC",
          "hgvs_p": null,
          "transcript": "ENST00000679722.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 9295,
          "mane_select": null,
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          "feature": null
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 49,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "n.4226_4228dupAAC",
          "hgvs_p": null,
          "transcript": "ENST00000680047.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 13866,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "n.4226_4228dupAAC",
          "hgvs_p": null,
          "transcript": "ENST00000680074.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 10080,
          "mane_select": null,
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          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 34,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "n.*3733_*3735dupAAC",
          "hgvs_p": null,
          "transcript": "ENST00000674381.2",
          "protein_id": "ENSP00000501536.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 8366,
          "mane_select": null,
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          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 34,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AKAP9",
          "gene_hgnc_id": 379,
          "hgvs_c": "n.*3789_*3791dupAAC",
          "hgvs_p": null,
          "transcript": "ENST00000679554.1",
          "protein_id": "ENSP00000506415.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 8638,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        }
      ],
      "gene_symbol": "AKAP9",
      "gene_hgnc_id": 379,
      "dbsnp": "rs10644111",
      "frequency_reference_population": 0.39514166,
      "hom_count_reference_population": 129701,
      "allele_count_reference_population": 633548,
      "gnomad_exomes_af": 0.389443,
      "gnomad_genomes_af": 0.449623,
      "gnomad_exomes_ac": 565279,
      "gnomad_genomes_ac": 68269,
      "gnomad_exomes_homalt": 113263,
      "gnomad_genomes_homalt": 16438,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": null,
      "computational_prediction_selected": null,
      "computational_source_selected": null,
      "splice_score_selected": null,
      "splice_prediction_selected": null,
      "splice_source_selected": null,
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": null,
      "bayesdelnoaf_prediction": null,
      "phylop100way_score": 1,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": null,
      "spliceai_max_prediction": null,
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -15,
      "acmg_classification": "Benign",
      "acmg_criteria": "PM4_Supporting,BP6_Very_Strong,BA1",
      "acmg_by_gene": [
        {
          "score": -15,
          "benign_score": 16,
          "pathogenic_score": 1,
          "criteria": [
            "PM4_Supporting",
            "BP6_Very_Strong",
            "BA1"
          ],
          "verdict": "Benign",
          "transcript": "ENST00000356239.8",
          "gene_symbol": "AKAP9",
          "hgnc_id": 379,
          "effects": [
            "disruptive_inframe_insertion"
          ],
          "inheritance_mode": "AD,AR",
          "hgvs_c": "c.4004_4006dupAAC",
          "hgvs_p": "p.Lys1335_Leu1336insGln"
        }
      ],
      "clinvar_disease": "Cardiovascular phenotype,Congenital long QT syndrome,Long QT syndrome,Long QT syndrome 11,not provided,not specified",
      "clinvar_classification": "Benign/Likely benign",
      "clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
      "clinvar_submissions_summary": "LB:1 B:11",
      "phenotype_combined": "not specified|Congenital long QT syndrome|Long QT syndrome|Cardiovascular phenotype|not provided|Long QT syndrome 11",
      "pathogenicity_classification_combined": "Benign/Likely benign",
      "custom_annotations": null
    }
  ],
  "message": null
}