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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 8-116847614-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=116847614&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "8",
"pos": 116847614,
"ref": "G",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "NM_006265.3",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAD21",
"gene_hgnc_id": 9811,
"hgvs_c": "c.1782C>G",
"hgvs_p": "p.Ala594Ala",
"transcript": "NM_006265.3",
"protein_id": "NP_006256.1",
"transcript_support_level": null,
"aa_start": 594,
"aa_end": null,
"aa_length": 631,
"cds_start": 1782,
"cds_end": null,
"cds_length": 1896,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000297338.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_006265.3"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAD21",
"gene_hgnc_id": 9811,
"hgvs_c": "c.1782C>G",
"hgvs_p": "p.Ala594Ala",
"transcript": "ENST00000297338.7",
"protein_id": "ENSP00000297338.2",
"transcript_support_level": 1,
"aa_start": 594,
"aa_end": null,
"aa_length": 631,
"cds_start": 1782,
"cds_end": null,
"cds_length": 1896,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_006265.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000297338.7"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAD21",
"gene_hgnc_id": 9811,
"hgvs_c": "c.1782C>G",
"hgvs_p": "p.Ala594Ala",
"transcript": "ENST00000517749.2",
"protein_id": "ENSP00000430273.2",
"transcript_support_level": 1,
"aa_start": 594,
"aa_end": null,
"aa_length": 631,
"cds_start": 1782,
"cds_end": null,
"cds_length": 1896,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000517749.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAD21",
"gene_hgnc_id": 9811,
"hgvs_c": "c.1782C>G",
"hgvs_p": "p.Ala594Ala",
"transcript": "ENST00000517485.6",
"protein_id": "ENSP00000427923.2",
"transcript_support_level": 3,
"aa_start": 594,
"aa_end": null,
"aa_length": 631,
"cds_start": 1782,
"cds_end": null,
"cds_length": 1896,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000517485.6"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAD21",
"gene_hgnc_id": 9811,
"hgvs_c": "c.1782C>G",
"hgvs_p": "p.Ala594Ala",
"transcript": "ENST00000519837.6",
"protein_id": "ENSP00000430524.2",
"transcript_support_level": 4,
"aa_start": 594,
"aa_end": null,
"aa_length": 631,
"cds_start": 1782,
"cds_end": null,
"cds_length": 1896,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000519837.6"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAD21",
"gene_hgnc_id": 9811,
"hgvs_c": "c.1782C>G",
"hgvs_p": "p.Ala594Ala",
"transcript": "ENST00000520992.6",
"protein_id": "ENSP00000429342.2",
"transcript_support_level": 4,
"aa_start": 594,
"aa_end": null,
"aa_length": 631,
"cds_start": 1782,
"cds_end": null,
"cds_length": 1896,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000520992.6"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAD21",
"gene_hgnc_id": 9811,
"hgvs_c": "c.1782C>G",
"hgvs_p": "p.Ala594Ala",
"transcript": "ENST00000522699.2",
"protein_id": "ENSP00000428158.2",
"transcript_support_level": 3,
"aa_start": 594,
"aa_end": null,
"aa_length": 631,
"cds_start": 1782,
"cds_end": null,
"cds_length": 1896,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000522699.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAD21",
"gene_hgnc_id": 9811,
"hgvs_c": "c.1782C>G",
"hgvs_p": "p.Ala594Ala",
"transcript": "ENST00000687358.1",
"protein_id": "ENSP00000509687.1",
"transcript_support_level": null,
"aa_start": 594,
"aa_end": null,
"aa_length": 631,
"cds_start": 1782,
"cds_end": null,
"cds_length": 1896,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000687358.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAD21",
"gene_hgnc_id": 9811,
"hgvs_c": "c.1782C>G",
"hgvs_p": "p.Ala594Ala",
"transcript": "ENST00000900009.1",
"protein_id": "ENSP00000570068.1",
"transcript_support_level": null,
"aa_start": 594,
"aa_end": null,
"aa_length": 631,
"cds_start": 1782,
"cds_end": null,
"cds_length": 1896,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900009.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAD21",
"gene_hgnc_id": 9811,
"hgvs_c": "c.1782C>G",
"hgvs_p": "p.Ala594Ala",
"transcript": "ENST00000900010.1",
"protein_id": "ENSP00000570069.1",
"transcript_support_level": null,
"aa_start": 594,
"aa_end": null,
"aa_length": 631,
"cds_start": 1782,
"cds_end": null,
"cds_length": 1896,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900010.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAD21",
"gene_hgnc_id": 9811,
"hgvs_c": "c.1782C>G",
"hgvs_p": "p.Ala594Ala",
"transcript": "ENST00000927340.1",
"protein_id": "ENSP00000597399.1",
"transcript_support_level": null,
"aa_start": 594,
"aa_end": null,
"aa_length": 631,
"cds_start": 1782,
"cds_end": null,
"cds_length": 1896,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927340.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAD21",
"gene_hgnc_id": 9811,
"hgvs_c": "c.1782C>G",
"hgvs_p": "p.Ala594Ala",
"transcript": "ENST00000958519.1",
"protein_id": "ENSP00000628578.1",
"transcript_support_level": null,
"aa_start": 594,
"aa_end": null,
"aa_length": 631,
"cds_start": 1782,
"cds_end": null,
"cds_length": 1896,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958519.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAD21",
"gene_hgnc_id": 9811,
"hgvs_c": "c.1776C>G",
"hgvs_p": "p.Ala592Ala",
"transcript": "ENST00000927337.1",
"protein_id": "ENSP00000597396.1",
"transcript_support_level": null,
"aa_start": 592,
"aa_end": null,
"aa_length": 629,
"cds_start": 1776,
"cds_end": null,
"cds_length": 1890,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927337.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAD21",
"gene_hgnc_id": 9811,
"hgvs_c": "c.1776C>G",
"hgvs_p": "p.Ala592Ala",
"transcript": "ENST00000927338.1",
"protein_id": "ENSP00000597397.1",
"transcript_support_level": null,
"aa_start": 592,
"aa_end": null,
"aa_length": 629,
"cds_start": 1776,
"cds_end": null,
"cds_length": 1890,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927338.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAD21",
"gene_hgnc_id": 9811,
"hgvs_c": "c.1773C>G",
"hgvs_p": "p.Ala591Ala",
"transcript": "ENST00000958517.1",
"protein_id": "ENSP00000628576.1",
"transcript_support_level": null,
"aa_start": 591,
"aa_end": null,
"aa_length": 628,
"cds_start": 1773,
"cds_end": null,
"cds_length": 1887,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958517.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAD21",
"gene_hgnc_id": 9811,
"hgvs_c": "c.1698C>G",
"hgvs_p": "p.Ala566Ala",
"transcript": "ENST00000900008.1",
"protein_id": "ENSP00000570067.1",
"transcript_support_level": null,
"aa_start": 566,
"aa_end": null,
"aa_length": 603,
"cds_start": 1698,
"cds_end": null,
"cds_length": 1812,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900008.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAD21",
"gene_hgnc_id": 9811,
"hgvs_c": "c.1698C>G",
"hgvs_p": "p.Ala566Ala",
"transcript": "ENST00000900011.1",
"protein_id": "ENSP00000570070.1",
"transcript_support_level": null,
"aa_start": 566,
"aa_end": null,
"aa_length": 603,
"cds_start": 1698,
"cds_end": null,
"cds_length": 1812,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900011.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAD21",
"gene_hgnc_id": 9811,
"hgvs_c": "c.1683C>G",
"hgvs_p": "p.Ala561Ala",
"transcript": "ENST00000927341.1",
"protein_id": "ENSP00000597400.1",
"transcript_support_level": null,
"aa_start": 561,
"aa_end": null,
"aa_length": 598,
"cds_start": 1683,
"cds_end": null,
"cds_length": 1797,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927341.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAD21",
"gene_hgnc_id": 9811,
"hgvs_c": "c.1683C>G",
"hgvs_p": "p.Ala561Ala",
"transcript": "ENST00000958518.1",
"protein_id": "ENSP00000628577.1",
"transcript_support_level": null,
"aa_start": 561,
"aa_end": null,
"aa_length": 598,
"cds_start": 1683,
"cds_end": null,
"cds_length": 1797,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958518.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAD21",
"gene_hgnc_id": 9811,
"hgvs_c": "c.447C>G",
"hgvs_p": "p.Ala149Ala",
"transcript": "ENST00000927339.1",
"protein_id": "ENSP00000597398.1",
"transcript_support_level": null,
"aa_start": 149,
"aa_end": null,
"aa_length": 186,
"cds_start": 447,
"cds_end": null,
"cds_length": 561,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927339.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAD21",
"gene_hgnc_id": 9811,
"hgvs_c": "c.222C>G",
"hgvs_p": "p.Ala74Ala",
"transcript": "ENST00000958516.1",
"protein_id": "ENSP00000628575.1",
"transcript_support_level": null,
"aa_start": 74,
"aa_end": null,
"aa_length": 111,
"cds_start": 222,
"cds_end": null,
"cds_length": 336,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958516.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "UTP23",
"gene_hgnc_id": 28224,
"hgvs_c": "c.189-1274G>C",
"hgvs_p": null,
"transcript": "ENST00000517820.1",
"protein_id": "ENSP00000427767.1",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 105,
"cds_start": null,
"cds_end": null,
"cds_length": 318,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000517820.1"
},
{
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{
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}
],
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}