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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 8-132817032-T-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=132817032&ref=T&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "8",
      "pos": 132817032,
      "ref": "T",
      "alt": "C",
      "effect": "missense_variant",
      "transcript": "NM_001438309.1",
      "consequences": [
        {
          "aa_ref": "F",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PHF20L1",
          "gene_hgnc_id": 24280,
          "hgvs_c": "c.1328T>C",
          "hgvs_p": "p.Phe443Ser",
          "transcript": "NM_016018.5",
          "protein_id": "NP_057102.4",
          "transcript_support_level": null,
          "aa_start": 443,
          "aa_end": null,
          "aa_length": 1017,
          "cds_start": 1328,
          "cds_end": null,
          "cds_length": 3054,
          "cdna_start": 1623,
          "cdna_end": null,
          "cdna_length": 6233,
          "mane_select": "ENST00000395386.7",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_016018.5"
        },
        {
          "aa_ref": "F",
          "aa_alt": "S",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PHF20L1",
          "gene_hgnc_id": 24280,
          "hgvs_c": "c.1328T>C",
          "hgvs_p": "p.Phe443Ser",
          "transcript": "ENST00000395386.7",
          "protein_id": "ENSP00000378784.2",
          "transcript_support_level": 5,
          "aa_start": 443,
          "aa_end": null,
          "aa_length": 1017,
          "cds_start": 1328,
          "cds_end": null,
          "cds_length": 3054,
          "cdna_start": 1623,
          "cdna_end": null,
          "cdna_length": 6233,
          "mane_select": "NM_016018.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000395386.7"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PHF20L1",
          "gene_hgnc_id": 24280,
          "hgvs_c": "n.1611T>C",
          "hgvs_p": null,
          "transcript": "ENST00000315808.14",
          "protein_id": null,
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2226,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000315808.14"
        },
        {
          "aa_ref": "F",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PHF20L1",
          "gene_hgnc_id": 24280,
          "hgvs_c": "c.1343T>C",
          "hgvs_p": "p.Phe448Ser",
          "transcript": "ENST00000939789.1",
          "protein_id": "ENSP00000609848.1",
          "transcript_support_level": null,
          "aa_start": 448,
          "aa_end": null,
          "aa_length": 1023,
          "cds_start": 1343,
          "cds_end": null,
          "cds_length": 3072,
          "cdna_start": 1659,
          "cdna_end": null,
          "cdna_length": 5056,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000939789.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PHF20L1",
          "gene_hgnc_id": 24280,
          "hgvs_c": "c.1343T>C",
          "hgvs_p": "p.Phe448Ser",
          "transcript": "NM_001438309.1",
          "protein_id": "NP_001425238.1",
          "transcript_support_level": null,
          "aa_start": 448,
          "aa_end": null,
          "aa_length": 1022,
          "cds_start": 1343,
          "cds_end": null,
          "cds_length": 3069,
          "cdna_start": 1634,
          "cdna_end": null,
          "cdna_length": 6244,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001438309.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PHF20L1",
          "gene_hgnc_id": 24280,
          "hgvs_c": "c.1340T>C",
          "hgvs_p": "p.Phe447Ser",
          "transcript": "NM_001438310.1",
          "protein_id": "NP_001425239.1",
          "transcript_support_level": null,
          "aa_start": 447,
          "aa_end": null,
          "aa_length": 1021,
          "cds_start": 1340,
          "cds_end": null,
          "cds_length": 3066,
          "cdna_start": 1631,
          "cdna_end": null,
          "cdna_length": 6241,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001438310.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PHF20L1",
          "gene_hgnc_id": 24280,
          "hgvs_c": "c.1340T>C",
          "hgvs_p": "p.Phe447Ser",
          "transcript": "ENST00000905699.1",
          "protein_id": "ENSP00000575758.1",
          "transcript_support_level": null,
          "aa_start": 447,
          "aa_end": null,
          "aa_length": 1021,
          "cds_start": 1340,
          "cds_end": null,
          "cds_length": 3066,
          "cdna_start": 1656,
          "cdna_end": null,
          "cdna_length": 5112,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000905699.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PHF20L1",
          "gene_hgnc_id": 24280,
          "hgvs_c": "c.1340T>C",
          "hgvs_p": "p.Phe447Ser",
          "transcript": "ENST00000972151.1",
          "protein_id": "ENSP00000642210.1",
          "transcript_support_level": null,
          "aa_start": 447,
          "aa_end": null,
          "aa_length": 1021,
          "cds_start": 1340,
          "cds_end": null,
          "cds_length": 3066,
          "cdna_start": 1668,
          "cdna_end": null,
          "cdna_length": 5329,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000972151.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PHF20L1",
          "gene_hgnc_id": 24280,
          "hgvs_c": "c.1331T>C",
          "hgvs_p": "p.Phe444Ser",
          "transcript": "NM_001438311.1",
          "protein_id": "NP_001425240.1",
          "transcript_support_level": null,
          "aa_start": 444,
          "aa_end": null,
          "aa_length": 1018,
          "cds_start": 1331,
          "cds_end": null,
          "cds_length": 3057,
          "cdna_start": 1622,
          "cdna_end": null,
          "cdna_length": 6232,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001438311.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PHF20L1",
          "gene_hgnc_id": 24280,
          "hgvs_c": "c.1331T>C",
          "hgvs_p": "p.Phe444Ser",
          "transcript": "ENST00000939786.1",
          "protein_id": "ENSP00000609845.1",
          "transcript_support_level": null,
          "aa_start": 444,
          "aa_end": null,
          "aa_length": 1018,
          "cds_start": 1331,
          "cds_end": null,
          "cds_length": 3057,
          "cdna_start": 1661,
          "cdna_end": null,
          "cdna_length": 5125,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000939786.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PHF20L1",
          "gene_hgnc_id": 24280,
          "hgvs_c": "c.1328T>C",
          "hgvs_p": "p.Phe443Ser",
          "transcript": "ENST00000939787.1",
          "protein_id": "ENSP00000609846.1",
          "transcript_support_level": null,
          "aa_start": 443,
          "aa_end": null,
          "aa_length": 1018,
          "cds_start": 1328,
          "cds_end": null,
          "cds_length": 3057,
          "cdna_start": 1659,
          "cdna_end": null,
          "cdna_length": 5118,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000939787.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PHF20L1",
          "gene_hgnc_id": 24280,
          "hgvs_c": "c.1331T>C",
          "hgvs_p": "p.Phe444Ser",
          "transcript": "ENST00000972150.1",
          "protein_id": "ENSP00000642209.1",
          "transcript_support_level": null,
          "aa_start": 444,
          "aa_end": null,
          "aa_length": 1018,
          "cds_start": 1331,
          "cds_end": null,
          "cds_length": 3057,
          "cdna_start": 1643,
          "cdna_end": null,
          "cdna_length": 6244,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000972150.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PHF20L1",
          "gene_hgnc_id": 24280,
          "hgvs_c": "c.1328T>C",
          "hgvs_p": "p.Phe443Ser",
          "transcript": "ENST00000622263.4",
          "protein_id": "ENSP00000482945.1",
          "transcript_support_level": 5,
          "aa_start": 443,
          "aa_end": null,
          "aa_length": 1017,
          "cds_start": 1328,
          "cds_end": null,
          "cds_length": 3054,
          "cdna_start": 1649,
          "cdna_end": null,
          "cdna_length": 3375,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000622263.4"
        },
        {
          "aa_ref": "F",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PHF20L1",
          "gene_hgnc_id": 24280,
          "hgvs_c": "c.1262T>C",
          "hgvs_p": "p.Phe421Ser",
          "transcript": "ENST00000972152.1",
          "protein_id": "ENSP00000642211.1",
          "transcript_support_level": null,
          "aa_start": 421,
          "aa_end": null,
          "aa_length": 995,
          "cds_start": 1262,
          "cds_end": null,
          "cds_length": 2988,
          "cdna_start": 1562,
          "cdna_end": null,
          "cdna_length": 4952,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000972152.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PHF20L1",
          "gene_hgnc_id": 24280,
          "hgvs_c": "c.1253T>C",
          "hgvs_p": "p.Phe418Ser",
          "transcript": "NM_001438312.1",
          "protein_id": "NP_001425241.1",
          "transcript_support_level": null,
          "aa_start": 418,
          "aa_end": null,
          "aa_length": 993,
          "cds_start": 1253,
          "cds_end": null,
          "cds_length": 2982,
          "cdna_start": 1548,
          "cdna_end": null,
          "cdna_length": 6161,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001438312.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PHF20L1",
          "gene_hgnc_id": 24280,
          "hgvs_c": "c.1253T>C",
          "hgvs_p": "p.Phe418Ser",
          "transcript": "ENST00000939788.1",
          "protein_id": "ENSP00000609847.1",
          "transcript_support_level": null,
          "aa_start": 418,
          "aa_end": null,
          "aa_length": 993,
          "cds_start": 1253,
          "cds_end": null,
          "cds_length": 2982,
          "cdna_start": 1555,
          "cdna_end": null,
          "cdna_length": 5022,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000939788.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PHF20L1",
          "gene_hgnc_id": 24280,
          "hgvs_c": "c.1253T>C",
          "hgvs_p": "p.Phe418Ser",
          "transcript": "ENST00000939790.1",
          "protein_id": "ENSP00000609849.1",
          "transcript_support_level": null,
          "aa_start": 418,
          "aa_end": null,
          "aa_length": 993,
          "cds_start": 1253,
          "cds_end": null,
          "cds_length": 2982,
          "cdna_start": 1568,
          "cdna_end": null,
          "cdna_length": 4965,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000939790.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PHF20L1",
          "gene_hgnc_id": 24280,
          "hgvs_c": "c.1250T>C",
          "hgvs_p": "p.Phe417Ser",
          "transcript": "NM_001438313.1",
          "protein_id": "NP_001425242.1",
          "transcript_support_level": null,
          "aa_start": 417,
          "aa_end": null,
          "aa_length": 992,
          "cds_start": 1250,
          "cds_end": null,
          "cds_length": 2979,
          "cdna_start": 1541,
          "cdna_end": null,
          "cdna_length": 6154,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001438313.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PHF20L1",
          "gene_hgnc_id": 24280,
          "hgvs_c": "c.1253T>C",
          "hgvs_p": "p.Phe418Ser",
          "transcript": "ENST00000395390.6",
          "protein_id": "ENSP00000378788.2",
          "transcript_support_level": 5,
          "aa_start": 418,
          "aa_end": null,
          "aa_length": 992,
          "cds_start": 1253,
          "cds_end": null,
          "cds_length": 2979,
          "cdna_start": 1290,
          "cdna_end": null,
          "cdna_length": 5900,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000395390.6"
        },
        {
          "aa_ref": "F",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PHF20L1",
          "gene_hgnc_id": 24280,
          "hgvs_c": "c.1253T>C",
          "hgvs_p": "p.Phe418Ser",
          "transcript": "ENST00000905700.1",
          "protein_id": "ENSP00000575759.1",
          "transcript_support_level": null,
          "aa_start": 418,
          "aa_end": null,
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      "clinvar_classification": "Uncertain significance",
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      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
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      "custom_annotations": null
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  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.