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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 8-141155921-G-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=141155921&ref=G&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 4,
          "criteria": [
            "PM2",
            "BP4_Strong"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "DENND3",
          "hgnc_id": 29134,
          "hgvs_c": "c.1147G>T",
          "hgvs_p": "p.Val383Leu",
          "inheritance_mode": "AR",
          "pathogenic_score": 2,
          "score": -2,
          "transcript": "NM_001362798.2",
          "verdict": "Likely_benign"
        }
      ],
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "PM2,BP4_Strong",
      "acmg_score": -2,
      "allele_count_reference_population": 5,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.0875,
      "alt": "T",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.74,
      "chr": "8",
      "clinvar_classification": "Uncertain significance",
      "clinvar_disease": "not specified",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": 0.05054503679275513,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1278,
          "aa_ref": "V",
          "aa_start": 383,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5527,
          "cdna_start": 1266,
          "cds_end": null,
          "cds_length": 3837,
          "cds_start": 1147,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 23,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "NM_001352890.3",
          "gene_hgnc_id": 29134,
          "gene_symbol": "DENND3",
          "hgvs_c": "c.1147G>T",
          "hgvs_p": "p.Val383Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000519811.6",
          "protein_coding": true,
          "protein_id": "NP_001339819.2",
          "strand": true,
          "transcript": "NM_001352890.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1278,
          "aa_ref": "V",
          "aa_start": 383,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 5527,
          "cdna_start": 1266,
          "cds_end": null,
          "cds_length": 3837,
          "cds_start": 1147,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 23,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000519811.6",
          "gene_hgnc_id": 29134,
          "gene_symbol": "DENND3",
          "hgvs_c": "c.1147G>T",
          "hgvs_p": "p.Val383Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_001352890.3",
          "protein_coding": true,
          "protein_id": "ENSP00000428714.1",
          "strand": true,
          "transcript": "ENST00000519811.6",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1146,
          "aa_ref": "V",
          "aa_start": 303,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4740,
          "cdna_start": 928,
          "cds_end": null,
          "cds_length": 3441,
          "cds_start": 907,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 21,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000424248.2",
          "gene_hgnc_id": 29134,
          "gene_symbol": "DENND3",
          "hgvs_c": "c.907G>T",
          "hgvs_p": "p.Val303Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000410594.1",
          "strand": true,
          "transcript": "ENST00000424248.2",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1296,
          "aa_ref": "V",
          "aa_start": 383,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6896,
          "cdna_start": 1266,
          "cds_end": null,
          "cds_length": 3891,
          "cds_start": 1147,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 22,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "NM_001362798.2",
          "gene_hgnc_id": 29134,
          "gene_symbol": "DENND3",
          "hgvs_c": "c.1147G>T",
          "hgvs_p": "p.Val383Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001349727.1",
          "strand": true,
          "transcript": "NM_001362798.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1274,
          "aa_ref": "V",
          "aa_start": 383,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5515,
          "cdna_start": 1266,
          "cds_end": null,
          "cds_length": 3825,
          "cds_start": 1147,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 23,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000885117.1",
          "gene_hgnc_id": 29134,
          "gene_symbol": "DENND3",
          "hgvs_c": "c.1147G>T",
          "hgvs_p": "p.Val383Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000555176.1",
          "strand": true,
          "transcript": "ENST00000885117.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1211,
          "aa_ref": "V",
          "aa_start": 316,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5478,
          "cdna_start": 1217,
          "cds_end": null,
          "cds_length": 3636,
          "cds_start": 946,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 23,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "NM_014957.5",
          "gene_hgnc_id": 29134,
          "gene_symbol": "DENND3",
          "hgvs_c": "c.946G>T",
          "hgvs_p": "p.Val316Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_055772.3",
          "strand": true,
          "transcript": "NM_014957.5",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1202,
          "aa_ref": "V",
          "aa_start": 359,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5185,
          "cdna_start": 1076,
          "cds_end": null,
          "cds_length": 3609,
          "cds_start": 1075,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 22,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000518668.5",
          "gene_hgnc_id": 29134,
          "gene_symbol": "DENND3",
          "hgvs_c": "c.1075G>T",
          "hgvs_p": "p.Val359Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000428276.1",
          "strand": true,
          "transcript": "ENST00000518668.5",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1198,
          "aa_ref": "V",
          "aa_start": 303,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5438,
          "cdna_start": 1185,
          "cds_end": null,
          "cds_length": 3597,
          "cds_start": 907,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 23,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000262585.6",
          "gene_hgnc_id": 29134,
          "gene_symbol": "DENND3",
          "hgvs_c": "c.907G>T",
          "hgvs_p": "p.Val303Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000262585.2",
          "strand": true,
          "transcript": "ENST00000262585.6",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1286,
          "aa_ref": "V",
          "aa_start": 383,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6630,
          "cdna_start": 1266,
          "cds_end": null,
          "cds_length": 3861,
          "cds_start": 1147,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 23,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "XM_011516933.3",
          "gene_hgnc_id": 29134,
          "gene_symbol": "DENND3",
          "hgvs_c": "c.1147G>T",
          "hgvs_p": "p.Val383Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_011515235.2",
          "strand": true,
          "transcript": "XM_011516933.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1244,
          "aa_ref": "V",
          "aa_start": 383,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3859,
          "cdna_start": 1266,
          "cds_end": null,
          "cds_length": 3735,
          "cds_start": 1147,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 21,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "XM_005250840.6",
          "gene_hgnc_id": 29134,
          "gene_symbol": "DENND3",
          "hgvs_c": "c.1147G>T",
          "hgvs_p": "p.Val383Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_005250897.3",
          "strand": true,
          "transcript": "XM_005250840.6",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1234,
          "aa_ref": "V",
          "aa_start": 383,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6474,
          "cdna_start": 1266,
          "cds_end": null,
          "cds_length": 3705,
          "cds_start": 1147,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 22,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "XM_047421591.1",
          "gene_hgnc_id": 29134,
          "gene_symbol": "DENND3",
          "hgvs_c": "c.1147G>T",
          "hgvs_p": "p.Val383Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_047277547.1",
          "strand": true,
          "transcript": "XM_047421591.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1226,
          "aa_ref": "V",
          "aa_start": 383,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5371,
          "cdna_start": 1266,
          "cds_end": null,
          "cds_length": 3681,
          "cds_start": 1147,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 22,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "XM_005250841.5",
          "gene_hgnc_id": 29134,
          "gene_symbol": "DENND3",
          "hgvs_c": "c.1147G>T",
          "hgvs_p": "p.Val383Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_005250898.3",
          "strand": true,
          "transcript": "XM_005250841.5",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1218,
          "aa_ref": "V",
          "aa_start": 305,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3781,
          "cdna_start": 1032,
          "cds_end": null,
          "cds_length": 3657,
          "cds_start": 913,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "XM_005250842.5",
          "gene_hgnc_id": 29134,
          "gene_symbol": "DENND3",
          "hgvs_c": "c.913G>T",
          "hgvs_p": "p.Val305Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_005250899.1",
          "strand": true,
          "transcript": "XM_005250842.5",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1217,
          "aa_ref": "V",
          "aa_start": 383,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5806,
          "cdna_start": 1266,
          "cds_end": null,
          "cds_length": 3654,
          "cds_start": 1147,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 23,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "XM_011516934.4",
          "gene_hgnc_id": 29134,
          "gene_symbol": "DENND3",
          "hgvs_c": "c.1147G>T",
          "hgvs_p": "p.Val383Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_011515236.2",
          "strand": true,
          "transcript": "XM_011516934.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1208,
          "aa_ref": "V",
          "aa_start": 305,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6396,
          "cdna_start": 1032,
          "cds_end": null,
          "cds_length": 3627,
          "cds_start": 913,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 21,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "XM_047421592.1",
          "gene_hgnc_id": 29134,
          "gene_symbol": "DENND3",
          "hgvs_c": "c.913G>T",
          "hgvs_p": "p.Val305Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_047277548.1",
          "strand": true,
          "transcript": "XM_047421592.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1200,
          "aa_ref": "V",
          "aa_start": 305,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5293,
          "cdna_start": 1032,
          "cds_end": null,
          "cds_length": 3603,
          "cds_start": 913,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 21,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "XM_047421593.1",
          "gene_hgnc_id": 29134,
          "gene_symbol": "DENND3",
          "hgvs_c": "c.913G>T",
          "hgvs_p": "p.Val305Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_047277549.1",
          "strand": true,
          "transcript": "XM_047421593.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1166,
          "aa_ref": "V",
          "aa_start": 305,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3625,
          "cdna_start": 1032,
          "cds_end": null,
          "cds_length": 3501,
          "cds_start": 913,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 19,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "XM_047421594.1",
          "gene_hgnc_id": 29134,
          "gene_symbol": "DENND3",
          "hgvs_c": "c.913G>T",
          "hgvs_p": "p.Val305Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_047277550.1",
          "strand": true,
          "transcript": "XM_047421594.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1165,
          "aa_ref": "V",
          "aa_start": 383,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5650,
          "cdna_start": 1266,
          "cds_end": null,
          "cds_length": 3498,
          "cds_start": 1147,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 22,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "XM_047421595.1",
          "gene_hgnc_id": 29134,
          "gene_symbol": "DENND3",
          "hgvs_c": "c.1147G>T",
          "hgvs_p": "p.Val383Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_047277551.1",
          "strand": true,
          "transcript": "XM_047421595.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1156,
          "aa_ref": "V",
          "aa_start": 383,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3689,
          "cdna_start": 1266,
          "cds_end": null,
          "cds_length": 3471,
          "cds_start": 1147,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 22,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "XM_047421596.1",
          "gene_hgnc_id": 29134,
          "gene_symbol": "DENND3",
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.