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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 8-141430961-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=141430961&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "8",
"pos": 141430961,
"ref": "A",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_032611.3",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.439A>G",
"hgvs_p": "p.Thr147Ala",
"transcript": "NM_032611.3",
"protein_id": "NP_116000.1",
"transcript_support_level": null,
"aa_start": 147,
"aa_end": null,
"aa_length": 173,
"cds_start": 439,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000521578.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032611.3"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.439A>G",
"hgvs_p": "p.Thr147Ala",
"transcript": "ENST00000521578.6",
"protein_id": "ENSP00000428976.1",
"transcript_support_level": 5,
"aa_start": 147,
"aa_end": null,
"aa_length": 173,
"cds_start": 439,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_032611.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000521578.6"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.439A>G",
"hgvs_p": "p.Thr147Ala",
"transcript": "ENST00000329397.6",
"protein_id": "ENSP00000332274.1",
"transcript_support_level": 1,
"aa_start": 147,
"aa_end": null,
"aa_length": 173,
"cds_start": 439,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000329397.6"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.439A>G",
"hgvs_p": "p.Thr147Ala",
"transcript": "ENST00000349124.3",
"protein_id": "ENSP00000331730.2",
"transcript_support_level": 1,
"aa_start": 147,
"aa_end": null,
"aa_length": 173,
"cds_start": 439,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000349124.3"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.577A>G",
"hgvs_p": "p.Thr193Ala",
"transcript": "ENST00000903103.1",
"protein_id": "ENSP00000573162.1",
"transcript_support_level": null,
"aa_start": 193,
"aa_end": null,
"aa_length": 219,
"cds_start": 577,
"cds_end": null,
"cds_length": 660,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903103.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.499A>G",
"hgvs_p": "p.Thr167Ala",
"transcript": "ENST00000903099.1",
"protein_id": "ENSP00000573158.1",
"transcript_support_level": null,
"aa_start": 167,
"aa_end": null,
"aa_length": 193,
"cds_start": 499,
"cds_end": null,
"cds_length": 582,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903099.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.439A>G",
"hgvs_p": "p.Thr147Ala",
"transcript": "NM_001438241.1",
"protein_id": "NP_001425170.1",
"transcript_support_level": null,
"aa_start": 147,
"aa_end": null,
"aa_length": 173,
"cds_start": 439,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001438241.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.439A>G",
"hgvs_p": "p.Thr147Ala",
"transcript": "NM_001438242.1",
"protein_id": "NP_001425171.1",
"transcript_support_level": null,
"aa_start": 147,
"aa_end": null,
"aa_length": 173,
"cds_start": 439,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001438242.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.439A>G",
"hgvs_p": "p.Thr147Ala",
"transcript": "ENST00000680615.1",
"protein_id": "ENSP00000505068.1",
"transcript_support_level": null,
"aa_start": 147,
"aa_end": null,
"aa_length": 173,
"cds_start": 439,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000680615.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.439A>G",
"hgvs_p": "p.Thr147Ala",
"transcript": "ENST00000903073.1",
"protein_id": "ENSP00000573132.1",
"transcript_support_level": null,
"aa_start": 147,
"aa_end": null,
"aa_length": 173,
"cds_start": 439,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903073.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.439A>G",
"hgvs_p": "p.Thr147Ala",
"transcript": "ENST00000903074.1",
"protein_id": "ENSP00000573133.1",
"transcript_support_level": null,
"aa_start": 147,
"aa_end": null,
"aa_length": 173,
"cds_start": 439,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903074.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.439A>G",
"hgvs_p": "p.Thr147Ala",
"transcript": "ENST00000903077.1",
"protein_id": "ENSP00000573136.1",
"transcript_support_level": null,
"aa_start": 147,
"aa_end": null,
"aa_length": 173,
"cds_start": 439,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903077.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.439A>G",
"hgvs_p": "p.Thr147Ala",
"transcript": "ENST00000903078.1",
"protein_id": "ENSP00000573137.1",
"transcript_support_level": null,
"aa_start": 147,
"aa_end": null,
"aa_length": 173,
"cds_start": 439,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903078.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.439A>G",
"hgvs_p": "p.Thr147Ala",
"transcript": "ENST00000903080.1",
"protein_id": "ENSP00000573139.1",
"transcript_support_level": null,
"aa_start": 147,
"aa_end": null,
"aa_length": 173,
"cds_start": 439,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903080.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.439A>G",
"hgvs_p": "p.Thr147Ala",
"transcript": "ENST00000903082.1",
"protein_id": "ENSP00000573141.1",
"transcript_support_level": null,
"aa_start": 147,
"aa_end": null,
"aa_length": 173,
"cds_start": 439,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903082.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.439A>G",
"hgvs_p": "p.Thr147Ala",
"transcript": "ENST00000903083.1",
"protein_id": "ENSP00000573142.1",
"transcript_support_level": null,
"aa_start": 147,
"aa_end": null,
"aa_length": 173,
"cds_start": 439,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903083.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.439A>G",
"hgvs_p": "p.Thr147Ala",
"transcript": "ENST00000903084.1",
"protein_id": "ENSP00000573143.1",
"transcript_support_level": null,
"aa_start": 147,
"aa_end": null,
"aa_length": 173,
"cds_start": 439,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903084.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.439A>G",
"hgvs_p": "p.Thr147Ala",
"transcript": "ENST00000903085.1",
"protein_id": "ENSP00000573144.1",
"transcript_support_level": null,
"aa_start": 147,
"aa_end": null,
"aa_length": 173,
"cds_start": 439,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903085.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.439A>G",
"hgvs_p": "p.Thr147Ala",
"transcript": "ENST00000903086.1",
"protein_id": "ENSP00000573145.1",
"transcript_support_level": null,
"aa_start": 147,
"aa_end": null,
"aa_length": 173,
"cds_start": 439,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903086.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.439A>G",
"hgvs_p": "p.Thr147Ala",
"transcript": "ENST00000903087.1",
"protein_id": "ENSP00000573146.1",
"transcript_support_level": null,
"aa_start": 147,
"aa_end": null,
"aa_length": 173,
"cds_start": 439,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903087.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.439A>G",
"hgvs_p": "p.Thr147Ala",
"transcript": "ENST00000903089.1",
"protein_id": "ENSP00000573148.1",
"transcript_support_level": null,
"aa_start": 147,
"aa_end": null,
"aa_length": 173,
"cds_start": 439,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903089.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTP4A3",
"gene_hgnc_id": 9636,
"hgvs_c": "c.439A>G",
"hgvs_p": "p.Thr147Ala",
"transcript": "ENST00000903093.1",
"protein_id": "ENSP00000573152.1",
"transcript_support_level": null,
"aa_start": 147,
"aa_end": null,
"aa_length": 173,
"cds_start": 439,
"cds_end": null,
"cds_length": 522,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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}