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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 8-143559981-G-GAGGGC (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=143559981&ref=G&alt=GAGGGC&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "8",
      "pos": 143559981,
      "ref": "G",
      "alt": "GAGGGC",
      "effect": "intron_variant",
      "transcript": "NM_024736.7",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "GSDMD",
          "gene_hgnc_id": 25697,
          "hgvs_c": "c.410+28_410+32dupAGGGC",
          "hgvs_p": null,
          "transcript": "NM_024736.7",
          "protein_id": "NP_079012.3",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 484,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1455,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000262580.9",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_024736.7"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "GSDMD",
          "gene_hgnc_id": 25697,
          "hgvs_c": "c.410+28_410+32dupAGGGC",
          "hgvs_p": null,
          "transcript": "ENST00000262580.9",
          "protein_id": "ENSP00000262580.4",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 484,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1455,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_024736.7",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000262580.9"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": 4,
          "intron_rank_end": null,
          "gene_symbol": "GSDMD",
          "gene_hgnc_id": 25697,
          "hgvs_c": "c.554+28_554+32dupAGGGC",
          "hgvs_p": null,
          "transcript": "ENST00000533063.5",
          "protein_id": "ENSP00000433958.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 532,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1599,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000533063.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "GSDMD",
          "gene_hgnc_id": 25697,
          "hgvs_c": "c.410+28_410+32dupAGGGC",
          "hgvs_p": null,
          "transcript": "NM_001166237.1",
          "protein_id": "NP_001159709.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 484,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1455,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001166237.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "GSDMD",
          "gene_hgnc_id": 25697,
          "hgvs_c": "c.410+28_410+32dupAGGGC",
          "hgvs_p": null,
          "transcript": "ENST00000526406.5",
          "protein_id": "ENSP00000433209.1",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 484,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1455,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000526406.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "GSDMD",
          "gene_hgnc_id": 25697,
          "hgvs_c": "c.410+28_410+32dupAGGGC",
          "hgvs_p": null,
          "transcript": "ENST00000866629.1",
          "protein_id": "ENSP00000536688.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 484,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1455,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000866629.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "GSDMD",
          "gene_hgnc_id": 25697,
          "hgvs_c": "c.410+28_410+32dupAGGGC",
          "hgvs_p": null,
          "transcript": "ENST00000866630.1",
          "protein_id": "ENSP00000536689.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 484,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1455,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000866630.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": 4,
          "intron_rank_end": null,
          "gene_symbol": "GSDMD",
          "gene_hgnc_id": 25697,
          "hgvs_c": "c.410+28_410+32dupAGGGC",
          "hgvs_p": null,
          "transcript": "ENST00000866631.1",
          "protein_id": "ENSP00000536690.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 484,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1455,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000866631.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": 4,
          "intron_rank_end": null,
          "gene_symbol": "GSDMD",
          "gene_hgnc_id": 25697,
          "hgvs_c": "c.410+28_410+32dupAGGGC",
          "hgvs_p": null,
          "transcript": "ENST00000866632.1",
          "protein_id": "ENSP00000536691.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 484,
          "cds_start": null,
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          "cds_length": 1455,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000866632.1"
        },
        {
          "aa_ref": null,
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          "canonical": false,
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          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 11,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "GSDMD",
          "gene_hgnc_id": 25697,
          "hgvs_c": "c.410+28_410+32dupAGGGC",
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          "transcript": "ENST00000866633.1",
          "protein_id": "ENSP00000536692.1",
          "transcript_support_level": null,
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          "cds_start": null,
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          "mane_select": null,
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        {
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          "intron_rank": 4,
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          "gene_symbol": "GSDMD",
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          "hgvs_c": "c.410+28_410+32dupAGGGC",
          "hgvs_p": null,
          "transcript": "ENST00000917301.1",
          "protein_id": "ENSP00000587360.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": 484,
          "cds_start": null,
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          "cdna_start": null,
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          "mane_select": null,
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        {
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        {
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          "gene_symbol": "GSDMD",
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          "gene_symbol": "GSDMD",
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          "transcript": "ENST00000533888.1",
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          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GSDMD",
          "gene_hgnc_id": 25697,
          "hgvs_c": "n.1085_1089dupAGGGC",
          "hgvs_p": null,
          "transcript": "ENST00000524846.5",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000524846.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "GSDMD",
          "gene_hgnc_id": 25697,
          "hgvs_c": "n.752+28_752+32dupAGGGC",
          "hgvs_p": null,
          "transcript": "ENST00000531184.5",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000531184.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "downstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GSDMD",
          "gene_hgnc_id": 25697,
          "hgvs_c": "c.*79_*80insAGGGC",
          "hgvs_p": null,
          "transcript": "ENST00000525721.1",
          "protein_id": "ENSP00000434452.1",
          "transcript_support_level": 4,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 113,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 343,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000525721.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "upstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GSDMD",
          "gene_hgnc_id": 25697,
          "hgvs_c": "n.-59_-58insAGGGC",
          "hgvs_p": null,
          "transcript": "ENST00000528475.1",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000528475.1"
        }
      ],
      "gene_symbol": "GSDMD",
      "gene_hgnc_id": 25697,
      "dbsnp": "rs59118283",
      "frequency_reference_population": 0.08554258,
      "hom_count_reference_population": 6409,
      "allele_count_reference_population": 135824,
      "gnomad_exomes_af": 0.0847395,
      "gnomad_genomes_af": 0.0931245,
      "gnomad_exomes_ac": 121662,
      "gnomad_genomes_ac": 14162,
      "gnomad_exomes_homalt": 5737,
      "gnomad_genomes_homalt": 672,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": null,
      "computational_prediction_selected": null,
      "computational_source_selected": null,
      "splice_score_selected": null,
      "splice_prediction_selected": null,
      "splice_source_selected": null,
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": null,
      "bayesdelnoaf_prediction": null,
      "phylop100way_score": 0.339,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": null,
      "spliceai_max_prediction": null,
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -10,
      "acmg_classification": "Benign",
      "acmg_criteria": "BP6_Moderate,BA1",
      "acmg_by_gene": [
        {
          "score": -10,
          "benign_score": 10,
          "pathogenic_score": 0,
          "criteria": [
            "BP6_Moderate",
            "BA1"
          ],
          "verdict": "Benign",
          "transcript": "NM_024736.7",
          "gene_symbol": "GSDMD",
          "hgnc_id": 25697,
          "effects": [
            "intron_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.410+28_410+32dupAGGGC",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Benign",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "B:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Benign",
      "custom_annotations": null
    }
  ],
  "message": null
}