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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 8-143576541-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=143576541&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "8",
"pos": 143576541,
"ref": "G",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "NM_145201.6",
"consequences": [
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "c.913C>T",
"hgvs_p": "p.Leu305Leu",
"transcript": "NM_145201.6",
"protein_id": "NP_660202.3",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 538,
"cds_start": 913,
"cds_end": null,
"cds_length": 1617,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000449291.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_145201.6"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "c.913C>T",
"hgvs_p": "p.Leu305Leu",
"transcript": "ENST00000449291.7",
"protein_id": "ENSP00000401508.2",
"transcript_support_level": 1,
"aa_start": 305,
"aa_end": null,
"aa_length": 538,
"cds_start": 913,
"cds_end": null,
"cds_length": 1617,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_145201.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000449291.7"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "c.913C>T",
"hgvs_p": "p.Leu305Leu",
"transcript": "ENST00000426292.7",
"protein_id": "ENSP00000390949.3",
"transcript_support_level": 1,
"aa_start": 305,
"aa_end": null,
"aa_length": 525,
"cds_start": 913,
"cds_end": null,
"cds_length": 1578,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000426292.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "n.913C>T",
"hgvs_p": null,
"transcript": "ENST00000340490.7",
"protein_id": "ENSP00000341136.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "non_stop_decay",
"feature": "ENST00000340490.7"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "c.1048C>T",
"hgvs_p": "p.Leu350Leu",
"transcript": "ENST00000955122.1",
"protein_id": "ENSP00000625181.1",
"transcript_support_level": null,
"aa_start": 350,
"aa_end": null,
"aa_length": 583,
"cds_start": 1048,
"cds_end": null,
"cds_length": 1752,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955122.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "c.973C>T",
"hgvs_p": "p.Leu325Leu",
"transcript": "ENST00000896706.1",
"protein_id": "ENSP00000566765.1",
"transcript_support_level": null,
"aa_start": 325,
"aa_end": null,
"aa_length": 558,
"cds_start": 973,
"cds_end": null,
"cds_length": 1677,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000896706.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "c.913C>T",
"hgvs_p": "p.Leu305Leu",
"transcript": "ENST00000896710.1",
"protein_id": "ENSP00000566769.1",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 552,
"cds_start": 913,
"cds_end": null,
"cds_length": 1659,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000896710.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "c.943C>T",
"hgvs_p": "p.Leu315Leu",
"transcript": "ENST00000896705.1",
"protein_id": "ENSP00000566764.1",
"transcript_support_level": null,
"aa_start": 315,
"aa_end": null,
"aa_length": 548,
"cds_start": 943,
"cds_end": null,
"cds_length": 1647,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000896705.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "c.913C>T",
"hgvs_p": "p.Leu305Leu",
"transcript": "ENST00000896712.1",
"protein_id": "ENSP00000566771.1",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 545,
"cds_start": 913,
"cds_end": null,
"cds_length": 1638,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000896712.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "c.910C>T",
"hgvs_p": "p.Leu304Leu",
"transcript": "ENST00000955117.1",
"protein_id": "ENSP00000625176.1",
"transcript_support_level": null,
"aa_start": 304,
"aa_end": null,
"aa_length": 537,
"cds_start": 910,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955117.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "c.898C>T",
"hgvs_p": "p.Leu300Leu",
"transcript": "ENST00000896711.1",
"protein_id": "ENSP00000566770.1",
"transcript_support_level": null,
"aa_start": 300,
"aa_end": null,
"aa_length": 533,
"cds_start": 898,
"cds_end": null,
"cds_length": 1602,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000896711.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "c.898C>T",
"hgvs_p": "p.Leu300Leu",
"transcript": "ENST00000896715.1",
"protein_id": "ENSP00000566774.1",
"transcript_support_level": null,
"aa_start": 300,
"aa_end": null,
"aa_length": 533,
"cds_start": 898,
"cds_end": null,
"cds_length": 1602,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000896715.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "c.913C>T",
"hgvs_p": "p.Leu305Leu",
"transcript": "NM_001286829.2",
"protein_id": "NP_001273758.1",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 525,
"cds_start": 913,
"cds_end": null,
"cds_length": 1578,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001286829.2"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "c.874C>T",
"hgvs_p": "p.Leu292Leu",
"transcript": "ENST00000896704.1",
"protein_id": "ENSP00000566763.1",
"transcript_support_level": null,
"aa_start": 292,
"aa_end": null,
"aa_length": 525,
"cds_start": 874,
"cds_end": null,
"cds_length": 1578,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000896704.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "c.874C>T",
"hgvs_p": "p.Leu292Leu",
"transcript": "ENST00000955120.1",
"protein_id": "ENSP00000625179.1",
"transcript_support_level": null,
"aa_start": 292,
"aa_end": null,
"aa_length": 525,
"cds_start": 874,
"cds_end": null,
"cds_length": 1578,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955120.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "c.910C>T",
"hgvs_p": "p.Leu304Leu",
"transcript": "ENST00000933605.1",
"protein_id": "ENSP00000603664.1",
"transcript_support_level": null,
"aa_start": 304,
"aa_end": null,
"aa_length": 524,
"cds_start": 910,
"cds_end": null,
"cds_length": 1575,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933605.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "c.868C>T",
"hgvs_p": "p.Leu290Leu",
"transcript": "ENST00000896708.1",
"protein_id": "ENSP00000566767.1",
"transcript_support_level": null,
"aa_start": 290,
"aa_end": null,
"aa_length": 523,
"cds_start": 868,
"cds_end": null,
"cds_length": 1572,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000896708.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "c.868C>T",
"hgvs_p": "p.Leu290Leu",
"transcript": "ENST00000896713.1",
"protein_id": "ENSP00000566772.1",
"transcript_support_level": null,
"aa_start": 290,
"aa_end": null,
"aa_length": 523,
"cds_start": 868,
"cds_end": null,
"cds_length": 1572,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000896713.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "c.928C>T",
"hgvs_p": "p.Leu310Leu",
"transcript": "ENST00000955118.1",
"protein_id": "ENSP00000625177.1",
"transcript_support_level": null,
"aa_start": 310,
"aa_end": null,
"aa_length": 516,
"cds_start": 928,
"cds_end": null,
"cds_length": 1551,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955118.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "c.913C>T",
"hgvs_p": "p.Leu305Leu",
"transcript": "NM_001363145.1",
"protein_id": "NP_001350074.1",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 511,
"cds_start": 913,
"cds_end": null,
"cds_length": 1536,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001363145.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "c.913C>T",
"hgvs_p": "p.Leu305Leu",
"transcript": "ENST00000896709.1",
"protein_id": "ENSP00000566768.1",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 511,
"cds_start": 913,
"cds_end": null,
"cds_length": 1536,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000896709.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NAPRT",
"gene_hgnc_id": 30450,
"hgvs_c": "c.820C>T",
"hgvs_p": "p.Leu274Leu",
"transcript": "ENST00000896707.1",
"protein_id": "ENSP00000566766.1",
"transcript_support_level": null,
"aa_start": 274,
"aa_end": null,
"aa_length": 507,
"cds_start": 820,
"cds_end": null,
"cds_length": 1524,
"cdna_start": null,
"cdna_end": null,
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