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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 8-143818403-CAT-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=143818403&ref=CAT&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "8",
      "pos": 143818403,
      "ref": "CAT",
      "alt": "C",
      "effect": "frameshift_variant",
      "transcript": "NM_001362895.2",
      "consequences": [
        {
          "aa_ref": "M",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PUF60",
          "gene_hgnc_id": 17042,
          "hgvs_c": "c.478_479delAT",
          "hgvs_p": "p.Met160fs",
          "transcript": "NM_078480.3",
          "protein_id": "NP_510965.1",
          "transcript_support_level": null,
          "aa_start": 160,
          "aa_end": null,
          "aa_length": 559,
          "cds_start": 478,
          "cds_end": null,
          "cds_length": 1680,
          "cdna_start": 491,
          "cdna_end": null,
          "cdna_length": 1868,
          "mane_select": "ENST00000526683.6",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_078480.3"
        },
        {
          "aa_ref": "M",
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PUF60",
          "gene_hgnc_id": 17042,
          "hgvs_c": "c.478_479delAT",
          "hgvs_p": "p.Met160fs",
          "transcript": "ENST00000526683.6",
          "protein_id": "ENSP00000434359.1",
          "transcript_support_level": 1,
          "aa_start": 160,
          "aa_end": null,
          "aa_length": 559,
          "cds_start": 478,
          "cds_end": null,
          "cds_length": 1680,
          "cdna_start": 491,
          "cdna_end": null,
          "cdna_length": 1868,
          "mane_select": "NM_078480.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000526683.6"
        },
        {
          "aa_ref": "M",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PUF60",
          "gene_hgnc_id": 17042,
          "hgvs_c": "c.427_428delAT",
          "hgvs_p": "p.Met143fs",
          "transcript": "ENST00000349157.10",
          "protein_id": "ENSP00000322036.7",
          "transcript_support_level": 1,
          "aa_start": 143,
          "aa_end": null,
          "aa_length": 542,
          "cds_start": 427,
          "cds_end": null,
          "cds_length": 1629,
          "cdna_start": 477,
          "cdna_end": null,
          "cdna_length": 1821,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000349157.10"
        },
        {
          "aa_ref": "M",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PUF60",
          "gene_hgnc_id": 17042,
          "hgvs_c": "c.349_350delAT",
          "hgvs_p": "p.Met117fs",
          "transcript": "ENST00000453551.6",
          "protein_id": "ENSP00000402953.2",
          "transcript_support_level": 1,
          "aa_start": 117,
          "aa_end": null,
          "aa_length": 516,
          "cds_start": 349,
          "cds_end": null,
          "cds_length": 1551,
          "cdna_start": 498,
          "cdna_end": null,
          "cdna_length": 1842,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000453551.6"
        },
        {
          "aa_ref": "M",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PUF60",
          "gene_hgnc_id": 17042,
          "hgvs_c": "c.298_299delAT",
          "hgvs_p": "p.Met100fs",
          "transcript": "ENST00000313352.11",
          "protein_id": "ENSP00000322016.7",
          "transcript_support_level": 1,
          "aa_start": 100,
          "aa_end": null,
          "aa_length": 499,
          "cds_start": 298,
          "cds_end": null,
          "cds_length": 1500,
          "cdna_start": 460,
          "cdna_end": null,
          "cdna_length": 1804,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000313352.11"
        },
        {
          "aa_ref": "M",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PUF60",
          "gene_hgnc_id": 17042,
          "hgvs_c": "c.589_590delAT",
          "hgvs_p": "p.Met197fs",
          "transcript": "NM_001362895.2",
          "protein_id": "NP_001349824.1",
          "transcript_support_level": null,
          "aa_start": 197,
          "aa_end": null,
          "aa_length": 596,
          "cds_start": 589,
          "cds_end": null,
          "cds_length": 1791,
          "cdna_start": 665,
          "cdna_end": null,
          "cdna_length": 2042,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001362895.2"
        },
        {
          "aa_ref": "M",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PUF60",
          "gene_hgnc_id": 17042,
          "hgvs_c": "c.589_590delAT",
          "hgvs_p": "p.Met197fs",
          "transcript": "NM_001362896.2",
          "protein_id": "NP_001349825.1",
          "transcript_support_level": null,
          "aa_start": 197,
          "aa_end": null,
          "aa_length": 596,
          "cds_start": 589,
          "cds_end": null,
          "cds_length": 1791,
          "cdna_start": 828,
          "cdna_end": null,
          "cdna_length": 2205,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001362896.2"
        },
        {
          "aa_ref": "M",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PUF60",
          "gene_hgnc_id": 17042,
          "hgvs_c": "c.589_590delAT",
          "hgvs_p": "p.Met197fs",
          "transcript": "ENST00000533162.2",
          "protein_id": "ENSP00000433403.2",
          "transcript_support_level": 3,
          "aa_start": 197,
          "aa_end": null,
          "aa_length": 596,
          "cds_start": 589,
          "cds_end": null,
          "cds_length": 1791,
          "cdna_start": 666,
          "cdna_end": null,
          "cdna_length": 1936,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000533162.2"
        },
        {
          "aa_ref": "M",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PUF60",
          "gene_hgnc_id": 17042,
          "hgvs_c": "c.589_590delAT",
          "hgvs_p": "p.Met197fs",
          "transcript": "ENST00000703847.1",
          "protein_id": "ENSP00000515499.1",
          "transcript_support_level": null,
          "aa_start": 197,
          "aa_end": null,
          "aa_length": 596,
          "cds_start": 589,
          "cds_end": null,
          "cds_length": 1791,
          "cdna_start": 828,
          "cdna_end": null,
          "cdna_length": 2140,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000703847.1"
        },
        {
          "aa_ref": "M",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PUF60",
          "gene_hgnc_id": 17042,
          "hgvs_c": "c.553_554delAT",
          "hgvs_p": "p.Met185fs",
          "transcript": "ENST00000533362.2",
          "protein_id": "ENSP00000515502.1",
          "transcript_support_level": 5,
          "aa_start": 185,
          "aa_end": null,
          "aa_length": 584,
          "cds_start": 553,
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          "cdna_start": 798,
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          "cdna_length": 2053,
          "mane_select": null,
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        },
        {
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          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 7,
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          "exon_count": 13,
          "intron_rank": null,
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          "gene_symbol": "PUF60",
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          "hgvs_c": "c.553_554delAT",
          "hgvs_p": "p.Met185fs",
          "transcript": "ENST00000703850.1",
          "protein_id": "ENSP00000515503.1",
          "transcript_support_level": null,
          "aa_start": 185,
          "aa_end": null,
          "aa_length": 584,
          "cds_start": 553,
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          "cdna_start": 705,
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          "cdna_length": 1952,
          "mane_select": null,
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          "biotype": "protein_coding",
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        {
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          "canonical": false,
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          "strand": false,
          "consequences": [
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          ],
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          "exon_count": 12,
          "intron_rank": null,
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          "gene_symbol": "PUF60",
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          "hgvs_c": "c.538_539delAT",
          "hgvs_p": "p.Met180fs",
          "transcript": "NM_001362897.2",
          "protein_id": "NP_001349826.1",
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          "aa_start": 180,
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          "aa_length": 579,
          "cds_start": 538,
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          "cds_length": 1740,
          "cdna_start": 614,
          "cdna_end": null,
          "cdna_length": 1991,
          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
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          "canonical": false,
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          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
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          "gene_symbol": "PUF60",
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          "hgvs_c": "c.478_479delAT",
          "hgvs_p": "p.Met160fs",
          "transcript": "ENST00000703866.1",
          "protein_id": "ENSP00000515511.1",
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          "cds_start": 478,
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        },
        {
          "aa_ref": "M",
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          "canonical": false,
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          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 6,
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          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PUF60",
          "gene_hgnc_id": 17042,
          "hgvs_c": "c.475_476delAT",
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          "transcript": "NM_001271098.2",
          "protein_id": "NP_001258027.1",
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        },
        {
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          "biotype": "protein_coding",
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        },
        {
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          "canonical": false,
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          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 6,
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          "exon_count": 12,
          "intron_rank": null,
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          "gene_symbol": "PUF60",
          "gene_hgnc_id": 17042,
          "hgvs_c": "c.472_473delAT",
          "hgvs_p": "p.Met158fs",
          "transcript": "ENST00000963445.1",
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        },
        {
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          "canonical": false,
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          "intron_rank": null,
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          "gene_symbol": "PUF60",
          "gene_hgnc_id": 17042,
          "hgvs_c": "c.478_479delAT",
          "hgvs_p": "p.Met160fs",
          "transcript": "ENST00000897215.1",
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        {
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          "intron_rank": null,
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          "gene_symbol": "PUF60",
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        },
        {
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          ],
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          "gene_symbol": "PUF60",
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          "biotype": "protein_coding",
          "feature": "NM_001271096.2"
        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PUF60",
          "gene_hgnc_id": 17042,
          "hgvs_c": "c.424_425delAT",
          "hgvs_p": "p.Met142fs",
          "transcript": "ENST00000526459.6",
          "protein_id": "ENSP00000432610.2",
          "transcript_support_level": 2,
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      "computational_score_selected": null,
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      "splice_prediction_selected": "Benign",
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          "transcript": "NM_001362895.2",
          "gene_symbol": "PUF60",
          "hgnc_id": 17042,
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      "clinvar_classification": "Likely pathogenic",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "LP:1 O:1",
      "phenotype_combined": "Inborn genetic diseases|8q24.3 microdeletion syndrome",
      "pathogenicity_classification_combined": "Likely pathogenic",
      "custom_annotations": null
    }
  ],
  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.