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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 8-144424059-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=144424059&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 1,
          "criteria": [
            "PM2",
            "BP4"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "VPS28",
          "hgnc_id": 18178,
          "hgvs_c": "c.530G>A",
          "hgvs_p": "p.Arg177His",
          "inheritance_mode": "AR",
          "pathogenic_score": 2,
          "score": 1,
          "transcript": "NM_183057.3",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4",
      "acmg_score": 1,
      "allele_count_reference_population": 67,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.3053,
      "alt": "T",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.13,
      "chr": "8",
      "clinvar_classification": "Uncertain significance",
      "clinvar_disease": "not specified",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": 0.2710208296775818,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 221,
          "aa_ref": "R",
          "aa_start": 177,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 948,
          "cdna_start": 624,
          "cds_end": null,
          "cds_length": 666,
          "cds_start": 530,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "NM_016208.4",
          "gene_hgnc_id": 18178,
          "gene_symbol": "VPS28",
          "hgvs_c": "c.530G>A",
          "hgvs_p": "p.Arg177His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000292510.6",
          "protein_coding": true,
          "protein_id": "NP_057292.1",
          "strand": false,
          "transcript": "NM_016208.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 221,
          "aa_ref": "R",
          "aa_start": 177,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 948,
          "cdna_start": 624,
          "cds_end": null,
          "cds_length": 666,
          "cds_start": 530,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000292510.6",
          "gene_hgnc_id": 18178,
          "gene_symbol": "VPS28",
          "hgvs_c": "c.530G>A",
          "hgvs_p": "p.Arg177His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_016208.4",
          "protein_coding": true,
          "protein_id": "ENSP00000292510.3",
          "strand": false,
          "transcript": "ENST00000292510.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 233,
          "aa_ref": "R",
          "aa_start": 177,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1097,
          "cdna_start": 639,
          "cds_end": null,
          "cds_length": 702,
          "cds_start": 530,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 9,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000377348.6",
          "gene_hgnc_id": 18178,
          "gene_symbol": "VPS28",
          "hgvs_c": "c.530G>A",
          "hgvs_p": "p.Arg177His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000366565.2",
          "strand": false,
          "transcript": "ENST00000377348.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 221,
          "aa_ref": "R",
          "aa_start": 177,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 892,
          "cdna_start": 568,
          "cds_end": null,
          "cds_length": 666,
          "cds_start": 530,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 9,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000526054.5",
          "gene_hgnc_id": 18178,
          "gene_symbol": "VPS28",
          "hgvs_c": "c.530G>A",
          "hgvs_p": "p.Arg177His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000434064.1",
          "strand": false,
          "transcript": "ENST00000526054.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 245,
          "aa_ref": "R",
          "aa_start": 201,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 985,
          "cdna_start": 667,
          "cds_end": null,
          "cds_length": 738,
          "cds_start": 602,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000969323.1",
          "gene_hgnc_id": 18178,
          "gene_symbol": "VPS28",
          "hgvs_c": "c.602G>A",
          "hgvs_p": "p.Arg201His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000639382.1",
          "strand": false,
          "transcript": "ENST00000969323.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 240,
          "aa_ref": "R",
          "aa_start": 196,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 984,
          "cdna_start": 661,
          "cds_end": null,
          "cds_length": 723,
          "cds_start": 587,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000909919.1",
          "gene_hgnc_id": 18178,
          "gene_symbol": "VPS28",
          "hgvs_c": "c.587G>A",
          "hgvs_p": "p.Arg196His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000579978.1",
          "strand": false,
          "transcript": "ENST00000909919.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 236,
          "aa_ref": "R",
          "aa_start": 192,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1112,
          "cdna_start": 788,
          "cds_end": null,
          "cds_length": 711,
          "cds_start": 575,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000969315.1",
          "gene_hgnc_id": 18178,
          "gene_symbol": "VPS28",
          "hgvs_c": "c.575G>A",
          "hgvs_p": "p.Arg192His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000639374.1",
          "strand": false,
          "transcript": "ENST00000969315.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 235,
          "aa_ref": "R",
          "aa_start": 191,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 985,
          "cdna_start": 661,
          "cds_end": null,
          "cds_length": 708,
          "cds_start": 572,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000909914.1",
          "gene_hgnc_id": 18178,
          "gene_symbol": "VPS28",
          "hgvs_c": "c.572G>A",
          "hgvs_p": "p.Arg191His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000579973.1",
          "strand": false,
          "transcript": "ENST00000909914.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 235,
          "aa_ref": "R",
          "aa_start": 191,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1097,
          "cdna_start": 774,
          "cds_end": null,
          "cds_length": 708,
          "cds_start": 572,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000909917.1",
          "gene_hgnc_id": 18178,
          "gene_symbol": "VPS28",
          "hgvs_c": "c.572G>A",
          "hgvs_p": "p.Arg191His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000579976.1",
          "strand": false,
          "transcript": "ENST00000909917.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 233,
          "aa_ref": "R",
          "aa_start": 177,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1066,
          "cdna_start": 624,
          "cds_end": null,
          "cds_length": 702,
          "cds_start": 530,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 9,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "NM_183057.3",
          "gene_hgnc_id": 18178,
          "gene_symbol": "VPS28",
          "hgvs_c": "c.530G>A",
          "hgvs_p": "p.Arg177His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_898880.1",
          "strand": false,
          "transcript": "NM_183057.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 233,
          "aa_ref": "R",
          "aa_start": 177,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1010,
          "cdna_start": 568,
          "cds_end": null,
          "cds_length": 702,
          "cds_start": 530,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000529182.5",
          "gene_hgnc_id": 18178,
          "gene_symbol": "VPS28",
          "hgvs_c": "c.530G>A",
          "hgvs_p": "p.Arg177His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000434556.1",
          "strand": false,
          "transcript": "ENST00000529182.5",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 231,
          "aa_ref": "R",
          "aa_start": 187,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 926,
          "cdna_start": 625,
          "cds_end": null,
          "cds_length": 696,
          "cds_start": 560,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000969326.1",
          "gene_hgnc_id": 18178,
          "gene_symbol": "VPS28",
          "hgvs_c": "c.560G>A",
          "hgvs_p": "p.Arg187His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000639385.1",
          "strand": false,
          "transcript": "ENST00000969326.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 229,
          "aa_ref": "R",
          "aa_start": 185,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 946,
          "cdna_start": 619,
          "cds_end": null,
          "cds_length": 690,
          "cds_start": 554,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000969319.1",
          "gene_hgnc_id": 18178,
          "gene_symbol": "VPS28",
          "hgvs_c": "c.554G>A",
          "hgvs_p": "p.Arg185His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000639378.1",
          "strand": false,
          "transcript": "ENST00000969319.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 225,
          "aa_ref": "R",
          "aa_start": 181,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 936,
          "cdna_start": 607,
          "cds_end": null,
          "cds_length": 678,
          "cds_start": 542,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000909921.1",
          "gene_hgnc_id": 18178,
          "gene_symbol": "VPS28",
          "hgvs_c": "c.542G>A",
          "hgvs_p": "p.Arg181His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000579980.1",
          "strand": false,
          "transcript": "ENST00000909921.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 221,
          "aa_ref": "R",
          "aa_start": 177,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1031,
          "cdna_start": 704,
          "cds_end": null,
          "cds_length": 666,
          "cds_start": 530,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000909910.1",
          "gene_hgnc_id": 18178,
          "gene_symbol": "VPS28",
          "hgvs_c": "c.530G>A",
          "hgvs_p": "p.Arg177His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000579969.1",
          "strand": false,
          "transcript": "ENST00000909910.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 221,
          "aa_ref": "R",
          "aa_start": 177,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1069,
          "cdna_start": 744,
          "cds_end": null,
          "cds_length": 666,
          "cds_start": 530,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000909911.1",
          "gene_hgnc_id": 18178,
          "gene_symbol": "VPS28",
          "hgvs_c": "c.530G>A",
          "hgvs_p": "p.Arg177His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000579970.1",
          "strand": false,
          "transcript": "ENST00000909911.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 221,
          "aa_ref": "R",
          "aa_start": 177,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1048,
          "cdna_start": 724,
          "cds_end": null,
          "cds_length": 666,
          "cds_start": 530,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000909912.1",
          "gene_hgnc_id": 18178,
          "gene_symbol": "VPS28",
          "hgvs_c": "c.530G>A",
          "hgvs_p": "p.Arg177His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000579971.1",
          "strand": false,
          "transcript": "ENST00000909912.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 221,
          "aa_ref": "R",
          "aa_start": 177,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 922,
          "cdna_start": 595,
          "cds_end": null,
          "cds_length": 666,
          "cds_start": 530,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000969316.1",
          "gene_hgnc_id": 18178,
          "gene_symbol": "VPS28",
          "hgvs_c": "c.530G>A",
          "hgvs_p": "p.Arg177His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000639375.1",
          "strand": false,
          "transcript": "ENST00000969316.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 221,
          "aa_ref": "R",
          "aa_start": 177,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1146,
          "cdna_start": 829,
          "cds_end": null,
          "cds_length": 666,
          "cds_start": 530,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000969317.1",
          "gene_hgnc_id": 18178,
          "gene_symbol": "VPS28",
          "hgvs_c": "c.530G>A",
          "hgvs_p": "p.Arg177His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000639376.1",
          "strand": false,
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.