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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 8-144425879-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=144425879&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "8",
"pos": 144425879,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_183057.3",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.105-107A>G",
"hgvs_p": null,
"transcript": "NM_016208.4",
"protein_id": "NP_057292.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 221,
"cds_start": null,
"cds_end": null,
"cds_length": 666,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 948,
"mane_select": "ENST00000292510.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_016208.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.105-107A>G",
"hgvs_p": null,
"transcript": "ENST00000292510.6",
"protein_id": "ENSP00000292510.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 221,
"cds_start": null,
"cds_end": null,
"cds_length": 666,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 948,
"mane_select": "NM_016208.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000292510.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.105-107A>G",
"hgvs_p": null,
"transcript": "ENST00000377348.6",
"protein_id": "ENSP00000366565.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 233,
"cds_start": null,
"cds_end": null,
"cds_length": 702,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1097,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000377348.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.105-107A>G",
"hgvs_p": null,
"transcript": "ENST00000526054.5",
"protein_id": "ENSP00000434064.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 221,
"cds_start": null,
"cds_end": null,
"cds_length": 666,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 892,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000526054.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.105-107A>G",
"hgvs_p": null,
"transcript": "ENST00000531032.5",
"protein_id": "ENSP00000434393.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 160,
"cds_start": null,
"cds_end": null,
"cds_length": 484,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 573,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000531032.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.-15A>G",
"hgvs_p": null,
"transcript": "XM_047421846.1",
"protein_id": "XP_047277802.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 183,
"cds_start": null,
"cds_end": null,
"cds_length": 552,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 893,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047421846.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.227+43A>G",
"hgvs_p": null,
"transcript": "ENST00000969323.1",
"protein_id": "ENSP00000639382.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 245,
"cds_start": null,
"cds_end": null,
"cds_length": 738,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 985,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969323.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.105-107A>G",
"hgvs_p": null,
"transcript": "ENST00000909919.1",
"protein_id": "ENSP00000579978.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 240,
"cds_start": null,
"cds_end": null,
"cds_length": 723,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 984,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909919.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.105-62A>G",
"hgvs_p": null,
"transcript": "ENST00000969315.1",
"protein_id": "ENSP00000639374.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 236,
"cds_start": null,
"cds_end": null,
"cds_length": 711,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1112,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969315.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.147-107A>G",
"hgvs_p": null,
"transcript": "ENST00000909914.1",
"protein_id": "ENSP00000579973.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 235,
"cds_start": null,
"cds_end": null,
"cds_length": 708,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 985,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909914.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.147-107A>G",
"hgvs_p": null,
"transcript": "ENST00000909917.1",
"protein_id": "ENSP00000579976.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 235,
"cds_start": null,
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"cds_length": 708,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909917.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.105-107A>G",
"hgvs_p": null,
"transcript": "NM_183057.3",
"protein_id": "NP_898880.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 233,
"cds_start": null,
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"cds_length": 702,
"cdna_start": null,
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"cdna_length": 1066,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_183057.3"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.105-107A>G",
"hgvs_p": null,
"transcript": "ENST00000529182.5",
"protein_id": "ENSP00000434556.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 233,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": 1010,
"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000529182.5"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 10,
"intron_rank": 4,
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"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.124-107A>G",
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"transcript": "ENST00000969326.1",
"protein_id": "ENSP00000639385.1",
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"biotype": "protein_coding",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 10,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.124-107A>G",
"hgvs_p": null,
"transcript": "ENST00000969319.1",
"protein_id": "ENSP00000639378.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 229,
"cds_start": null,
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"cds_length": 690,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969319.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.105-95A>G",
"hgvs_p": null,
"transcript": "ENST00000909921.1",
"protein_id": "ENSP00000579980.1",
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"cds_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000909921.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.105-107A>G",
"hgvs_p": null,
"transcript": "ENST00000909910.1",
"protein_id": "ENSP00000579969.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"cds_length": 666,
"cdna_start": null,
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"cdna_length": 1031,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909910.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.105-107A>G",
"hgvs_p": null,
"transcript": "ENST00000909911.1",
"protein_id": "ENSP00000579970.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 221,
"cds_start": null,
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"cds_length": 666,
"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000909911.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.105-107A>G",
"hgvs_p": null,
"transcript": "ENST00000909912.1",
"protein_id": "ENSP00000579971.1",
"transcript_support_level": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000909912.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 10,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.105-107A>G",
"hgvs_p": null,
"transcript": "ENST00000969316.1",
"protein_id": "ENSP00000639375.1",
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"aa_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000969316.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.105-107A>G",
"hgvs_p": null,
"transcript": "ENST00000969317.1",
"protein_id": "ENSP00000639376.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 221,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": 1146,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969317.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "VPS28",
"gene_hgnc_id": 18178,
"hgvs_c": "c.105-107A>G",
"hgvs_p": null,
"transcript": "ENST00000969318.1",
"protein_id": "ENSP00000639377.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 221,
"cds_start": null,
"cds_end": null,
"cds_length": 666,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 929,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969318.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 4,
"intron_rank_end": null,
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}
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}