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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 8-144504326-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=144504326&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "8",
"pos": 144504326,
"ref": "C",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "NM_005309.3",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "NM_005309.3",
"protein_id": "NP_005300.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 496,
"cds_start": 22,
"cds_end": null,
"cds_length": 1491,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000394955.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_005309.3"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "ENST00000394955.3",
"protein_id": "ENSP00000378408.2",
"transcript_support_level": 1,
"aa_start": 8,
"aa_end": null,
"aa_length": 496,
"cds_start": 22,
"cds_end": null,
"cds_length": 1491,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_005309.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000394955.3"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "ENST00000528431.5",
"protein_id": "ENSP00000433586.1",
"transcript_support_level": 1,
"aa_start": 8,
"aa_end": null,
"aa_length": 496,
"cds_start": 22,
"cds_end": null,
"cds_length": 1491,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000528431.5"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "ENST00000894981.1",
"protein_id": "ENSP00000565040.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 508,
"cds_start": 22,
"cds_end": null,
"cds_length": 1527,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894981.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "NM_001382664.1",
"protein_id": "NP_001369593.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 496,
"cds_start": 22,
"cds_end": null,
"cds_length": 1491,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001382664.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "NM_001382665.1",
"protein_id": "NP_001369594.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 496,
"cds_start": 22,
"cds_end": null,
"cds_length": 1491,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001382665.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "ENST00000894967.1",
"protein_id": "ENSP00000565026.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 496,
"cds_start": 22,
"cds_end": null,
"cds_length": 1491,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894967.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "ENST00000894968.1",
"protein_id": "ENSP00000565027.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 496,
"cds_start": 22,
"cds_end": null,
"cds_length": 1491,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894968.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "ENST00000894969.1",
"protein_id": "ENSP00000565028.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 496,
"cds_start": 22,
"cds_end": null,
"cds_length": 1491,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894969.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "ENST00000894970.1",
"protein_id": "ENSP00000565029.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 496,
"cds_start": 22,
"cds_end": null,
"cds_length": 1491,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894970.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "ENST00000894972.1",
"protein_id": "ENSP00000565031.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 496,
"cds_start": 22,
"cds_end": null,
"cds_length": 1491,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894972.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "ENST00000894973.1",
"protein_id": "ENSP00000565032.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 496,
"cds_start": 22,
"cds_end": null,
"cds_length": 1491,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894973.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "ENST00000894974.1",
"protein_id": "ENSP00000565033.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 496,
"cds_start": 22,
"cds_end": null,
"cds_length": 1491,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894974.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "ENST00000894975.1",
"protein_id": "ENSP00000565034.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 496,
"cds_start": 22,
"cds_end": null,
"cds_length": 1491,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894975.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "ENST00000894978.1",
"protein_id": "ENSP00000565037.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 495,
"cds_start": 22,
"cds_end": null,
"cds_length": 1488,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894978.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "ENST00000894979.1",
"protein_id": "ENSP00000565038.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 493,
"cds_start": 22,
"cds_end": null,
"cds_length": 1482,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894979.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "ENST00000894977.1",
"protein_id": "ENSP00000565036.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 488,
"cds_start": 22,
"cds_end": null,
"cds_length": 1467,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894977.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "ENST00000894983.1",
"protein_id": "ENSP00000565042.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 484,
"cds_start": 22,
"cds_end": null,
"cds_length": 1455,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894983.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "ENST00000894980.1",
"protein_id": "ENSP00000565039.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 478,
"cds_start": 22,
"cds_end": null,
"cds_length": 1437,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894980.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "ENST00000894982.1",
"protein_id": "ENSP00000565041.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 475,
"cds_start": 22,
"cds_end": null,
"cds_length": 1428,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894982.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "ENST00000961468.1",
"protein_id": "ENSP00000631527.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 472,
"cds_start": 22,
"cds_end": null,
"cds_length": 1419,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961468.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPT",
"gene_hgnc_id": 4552,
"hgvs_c": "c.22C>A",
"hgvs_p": "p.Arg8Arg",
"transcript": "ENST00000961471.1",
"protein_id": "ENSP00000631530.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 466,
"cds_start": 22,
"cds_end": null,
"cds_length": 1401,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961471.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
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}