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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 8-15592786-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=15592786&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "8",
"pos": 15592786,
"ref": "G",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000503731.6",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TUSC3",
"gene_hgnc_id": 30242,
"hgvs_c": "c.139-30294G>A",
"hgvs_p": null,
"transcript": "NM_006765.4",
"protein_id": "NP_006756.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 348,
"cds_start": -4,
"cds_end": null,
"cds_length": 1047,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3697,
"mane_select": "ENST00000503731.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TUSC3",
"gene_hgnc_id": 30242,
"hgvs_c": "c.139-30294G>A",
"hgvs_p": null,
"transcript": "ENST00000503731.6",
"protein_id": "ENSP00000424544.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 348,
"cds_start": -4,
"cds_end": null,
"cds_length": 1047,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3697,
"mane_select": "NM_006765.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TUSC3",
"gene_hgnc_id": 30242,
"hgvs_c": "c.139-30294G>A",
"hgvs_p": null,
"transcript": "ENST00000382020.8",
"protein_id": "ENSP00000371450.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 347,
"cds_start": -4,
"cds_end": null,
"cds_length": 1044,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3683,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TUSC3",
"gene_hgnc_id": 30242,
"hgvs_c": "c.139-30294G>A",
"hgvs_p": null,
"transcript": "NM_001413679.1",
"protein_id": "NP_001400608.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 408,
"cds_start": -4,
"cds_end": null,
"cds_length": 1227,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4414,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TUSC3",
"gene_hgnc_id": 30242,
"hgvs_c": "c.139-30294G>A",
"hgvs_p": null,
"transcript": "NM_001413684.1",
"protein_id": "NP_001400613.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 394,
"cds_start": -4,
"cds_end": null,
"cds_length": 1185,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4505,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TUSC3",
"gene_hgnc_id": 30242,
"hgvs_c": "c.139-30294G>A",
"hgvs_p": null,
"transcript": "NM_001413673.1",
"protein_id": "NP_001400602.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 359,
"cds_start": -4,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1444,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TUSC3",
"gene_hgnc_id": 30242,
"hgvs_c": "c.139-30294G>A",
"hgvs_p": null,
"transcript": "NM_001413686.1",
"protein_id": "NP_001400615.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 351,
"cds_start": -4,
"cds_end": null,
"cds_length": 1056,
"cdna_start": null,
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"cdna_length": 2851,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TUSC3",
"gene_hgnc_id": 30242,
"hgvs_c": "c.139-30294G>A",
"hgvs_p": null,
"transcript": "NM_001413683.1",
"protein_id": "NP_001400612.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 350,
"cds_start": -4,
"cds_end": null,
"cds_length": 1053,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2848,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TUSC3",
"gene_hgnc_id": 30242,
"hgvs_c": "c.139-30294G>A",
"hgvs_p": null,
"transcript": "NM_001356429.2",
"protein_id": "NP_001343358.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 348,
"cds_start": -4,
"cds_end": null,
"cds_length": 1047,
"cdna_start": null,
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"cdna_length": 3899,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 1,
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"gene_symbol": "TUSC3",
"gene_hgnc_id": 30242,
"hgvs_c": "c.139-30294G>A",
"hgvs_p": null,
"transcript": "NM_001413583.1",
"protein_id": "NP_001400512.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 1,
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"gene_symbol": "TUSC3",
"gene_hgnc_id": 30242,
"hgvs_c": "c.139-30294G>A",
"hgvs_p": null,
"transcript": "NM_001413689.1",
"protein_id": "NP_001400618.1",
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},
{
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],
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},
{
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],
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"gene_symbol": "TUSC3",
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"hgvs_c": "c.139-30294G>A",
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],
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"gene_symbol": "TUSC3",
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"hgvs_c": "c.139-30294G>A",
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},
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],
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"transcript": "NM_001413682.1",
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},
{
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],
"exon_rank": null,
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"gene_symbol": "TUSC3",
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"hgvs_c": "c.79-30294G>A",
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},
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"gene_symbol": "TUSC3",
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"hgvs_c": "c.139-30294G>A",
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},
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],
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"gene_symbol": "TUSC3",
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"hgvs_c": "c.139-30294G>A",
"hgvs_p": null,
"transcript": "NM_001413685.1",
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},
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],
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],
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],
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},
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"consequences": [
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],
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"gene_symbol": "TUSC3",
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"hgvs_c": "c.-30-30294G>A",
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"transcript": "NM_001413671.1",
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},
{
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "TUSC3",
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"hgvs_c": "c.-30-30294G>A",
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"transcript": "NM_001413669.1",
"protein_id": "NP_001400598.1",
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