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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 8-22505519-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=22505519&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "8",
"pos": 22505519,
"ref": "C",
"alt": "T",
"effect": "intron_variant",
"transcript": "NM_001243974.2",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP3CC",
"gene_hgnc_id": 9316,
"hgvs_c": "c.485-5567C>T",
"hgvs_p": null,
"transcript": "NM_005605.5",
"protein_id": "NP_005596.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 512,
"cds_start": null,
"cds_end": null,
"cds_length": 1539,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000240139.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_005605.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP3CC",
"gene_hgnc_id": 9316,
"hgvs_c": "c.485-5567C>T",
"hgvs_p": null,
"transcript": "ENST00000240139.10",
"protein_id": "ENSP00000240139.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 512,
"cds_start": null,
"cds_end": null,
"cds_length": 1539,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_005605.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000240139.10"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP3CC",
"gene_hgnc_id": 9316,
"hgvs_c": "c.485-5567C>T",
"hgvs_p": null,
"transcript": "ENST00000289963.12",
"protein_id": "ENSP00000289963.8",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 502,
"cds_start": null,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000289963.12"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP3CC",
"gene_hgnc_id": 9316,
"hgvs_c": "c.485-5567C>T",
"hgvs_p": null,
"transcript": "ENST00000968566.1",
"protein_id": "ENSP00000638625.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 540,
"cds_start": null,
"cds_end": null,
"cds_length": 1623,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968566.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "PPP3CC",
"gene_hgnc_id": 9316,
"hgvs_c": "c.536-5567C>T",
"hgvs_p": null,
"transcript": "ENST00000898953.1",
"protein_id": "ENSP00000569012.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 529,
"cds_start": null,
"cds_end": null,
"cds_length": 1590,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898953.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP3CC",
"gene_hgnc_id": 9316,
"hgvs_c": "c.485-5567C>T",
"hgvs_p": null,
"transcript": "NM_001243974.2",
"protein_id": "NP_001230903.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 521,
"cds_start": null,
"cds_end": null,
"cds_length": 1566,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001243974.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP3CC",
"gene_hgnc_id": 9316,
"hgvs_c": "c.485-5567C>T",
"hgvs_p": null,
"transcript": "ENST00000397775.7",
"protein_id": "ENSP00000380878.3",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 521,
"cds_start": null,
"cds_end": null,
"cds_length": 1566,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000397775.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "PPP3CC",
"gene_hgnc_id": 9316,
"hgvs_c": "c.536-5567C>T",
"hgvs_p": null,
"transcript": "ENST00000898949.1",
"protein_id": "ENSP00000569008.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 519,
"cds_start": null,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898949.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP3CC",
"gene_hgnc_id": 9316,
"hgvs_c": "c.485-5567C>T",
"hgvs_p": null,
"transcript": "ENST00000968572.1",
"protein_id": "ENSP00000638631.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 518,
"cds_start": null,
"cds_end": null,
"cds_length": 1557,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968572.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP3CC",
"gene_hgnc_id": 9316,
"hgvs_c": "c.485-5567C>T",
"hgvs_p": null,
"transcript": "ENST00000968565.1",
"protein_id": "ENSP00000638624.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 511,
"cds_start": null,
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"cds_length": 1536,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968565.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP3CC",
"gene_hgnc_id": 9316,
"hgvs_c": "c.485-5567C>T",
"hgvs_p": null,
"transcript": "ENST00000968574.1",
"protein_id": "ENSP00000638633.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 507,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968574.1"
},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 13,
"intron_rank": 4,
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"gene_symbol": "PPP3CC",
"gene_hgnc_id": 9316,
"hgvs_c": "c.485-5567C>T",
"hgvs_p": null,
"transcript": "NM_001243975.2",
"protein_id": "NP_001230904.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001243975.2"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP3CC",
"gene_hgnc_id": 9316,
"hgvs_c": "c.485-5567C>T",
"hgvs_p": null,
"transcript": "ENST00000898952.1",
"protein_id": "ENSP00000569011.1",
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"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898952.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 14,
"intron_rank": 4,
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"gene_symbol": "PPP3CC",
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"hgvs_c": "c.485-5567C>T",
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"transcript": "ENST00000968569.1",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 13,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP3CC",
"gene_hgnc_id": 9316,
"hgvs_c": "c.485-5567C>T",
"hgvs_p": null,
"transcript": "ENST00000898955.1",
"protein_id": "ENSP00000569014.1",
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"aa_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000898955.1"
},
{
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"strand": true,
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],
"exon_rank": null,
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"exon_count": 14,
"intron_rank": 4,
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"gene_symbol": "PPP3CC",
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"hgvs_c": "c.485-6647C>T",
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"transcript": "ENST00000898957.1",
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"biotype": "protein_coding",
"feature": "ENST00000898957.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP3CC",
"gene_hgnc_id": 9316,
"hgvs_c": "c.485-5567C>T",
"hgvs_p": null,
"transcript": "ENST00000968573.1",
"protein_id": "ENSP00000638632.1",
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"biotype": "protein_coding",
"feature": "ENST00000968573.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP3CC",
"gene_hgnc_id": 9316,
"hgvs_c": "c.485-5567C>T",
"hgvs_p": null,
"transcript": "ENST00000898951.1",
"protein_id": "ENSP00000569010.1",
"transcript_support_level": null,
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},
{
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],
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"intron_rank": 4,
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"gene_symbol": "PPP3CC",
"gene_hgnc_id": 9316,
"hgvs_c": "c.485-5567C>T",
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},
{
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"strand": true,
"consequences": [
"intron_variant"
],
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"intron_rank": 3,
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"gene_symbol": "PPP3CC",
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"hgvs_c": "c.373-5650C>T",
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"transcript": "ENST00000968567.1",
"protein_id": "ENSP00000638626.1",
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},
{
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"strand": true,
"consequences": [
"intron_variant"
],
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"intron_rank": 3,
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"gene_symbol": "PPP3CC",
"gene_hgnc_id": 9316,
"hgvs_c": "c.373-5650C>T",
"hgvs_p": null,
"transcript": "ENST00000968570.1",
"protein_id": "ENSP00000638629.1",
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968570.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP3CC",
"gene_hgnc_id": 9316,
"hgvs_c": "c.485-5567C>T",
"hgvs_p": null,
"transcript": "ENST00000898950.1",
"protein_id": "ENSP00000569009.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 446,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898950.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
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