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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 8-22605806-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=22605806&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "8",
"pos": 22605806,
"ref": "G",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_021174.6",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "NM_001393997.1",
"protein_id": "NP_001380926.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 923,
"cds_start": 33,
"cds_end": null,
"cds_length": 2772,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000308511.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001393997.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "ENST00000308511.9",
"protein_id": "ENSP00000310670.4",
"transcript_support_level": 1,
"aa_start": 11,
"aa_end": null,
"aa_length": 923,
"cds_start": 33,
"cds_end": null,
"cds_length": 2772,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001393997.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000308511.9"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "ENST00000389279.7",
"protein_id": "ENSP00000373930.3",
"transcript_support_level": 1,
"aa_start": 11,
"aa_end": null,
"aa_length": 923,
"cds_start": 33,
"cds_end": null,
"cds_length": 2772,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000389279.7"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "ENST00000952221.1",
"protein_id": "ENSP00000622280.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 972,
"cds_start": 33,
"cds_end": null,
"cds_length": 2919,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000952221.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "ENST00000910077.1",
"protein_id": "ENSP00000580136.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 965,
"cds_start": 33,
"cds_end": null,
"cds_length": 2898,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910077.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "ENST00000910074.1",
"protein_id": "ENSP00000580133.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 928,
"cds_start": 33,
"cds_end": null,
"cds_length": 2787,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910074.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "ENST00000939464.1",
"protein_id": "ENSP00000609523.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 927,
"cds_start": 33,
"cds_end": null,
"cds_length": 2784,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939464.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "ENST00000939466.1",
"protein_id": "ENSP00000609525.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 927,
"cds_start": 33,
"cds_end": null,
"cds_length": 2784,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939466.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "NM_021174.6",
"protein_id": "NP_066997.3",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 923,
"cds_start": 33,
"cds_end": null,
"cds_length": 2772,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_021174.6"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "ENST00000910079.1",
"protein_id": "ENSP00000580138.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 923,
"cds_start": 33,
"cds_end": null,
"cds_length": 2772,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910079.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "ENST00000910080.1",
"protein_id": "ENSP00000580139.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 923,
"cds_start": 33,
"cds_end": null,
"cds_length": 2772,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910080.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "NM_001363068.2",
"protein_id": "NP_001349997.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 922,
"cds_start": 33,
"cds_end": null,
"cds_length": 2769,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001363068.2"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "NM_001363069.2",
"protein_id": "NP_001349998.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 922,
"cds_start": 33,
"cds_end": null,
"cds_length": 2769,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001363069.2"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "ENST00000910071.1",
"protein_id": "ENSP00000580130.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 922,
"cds_start": 33,
"cds_end": null,
"cds_length": 2769,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910071.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "ENST00000910073.1",
"protein_id": "ENSP00000580132.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 922,
"cds_start": 33,
"cds_end": null,
"cds_length": 2769,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910073.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "ENST00000910078.1",
"protein_id": "ENSP00000580137.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 922,
"cds_start": 33,
"cds_end": null,
"cds_length": 2769,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910078.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "ENST00000939465.1",
"protein_id": "ENSP00000609524.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 922,
"cds_start": 33,
"cds_end": null,
"cds_length": 2769,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939465.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "ENST00000939462.1",
"protein_id": "ENSP00000609521.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 920,
"cds_start": 33,
"cds_end": null,
"cds_length": 2763,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939462.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "ENST00000910072.1",
"protein_id": "ENSP00000580131.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 916,
"cds_start": 33,
"cds_end": null,
"cds_length": 2751,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910072.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "ENST00000910076.1",
"protein_id": "ENSP00000580135.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 913,
"cds_start": 33,
"cds_end": null,
"cds_length": 2742,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910076.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "ENST00000910075.1",
"protein_id": "ENSP00000580134.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 885,
"cds_start": 33,
"cds_end": null,
"cds_length": 2658,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910075.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCAR2",
"gene_hgnc_id": 23360,
"hgvs_c": "c.33G>T",
"hgvs_p": "p.Pro11Pro",
"transcript": "ENST00000939463.1",
"protein_id": "ENSP00000609522.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 874,
"cds_start": 33,
"cds_end": null,
"cds_length": 2625,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
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"feature": "ENST00000939463.1"
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"splice_prediction_selected": "Benign",
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"phylop100way_prediction": "Benign",
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"acmg_by_gene": [
{
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"BP4_Strong",
"BP7"
],
"verdict": "Likely_benign",
"transcript": "NM_021174.6",
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"inheritance_mode": "",
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],
"clinvar_disease": "",
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"clinvar_review_status": "",
"clinvar_submissions_summary": "",
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"pathogenicity_classification_combined": null,
"custom_annotations": null
}
],
"message": null
}