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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 8-26348561-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=26348561&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "8",
"pos": 26348561,
"ref": "C",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000380737.8",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "PPP2R2A",
"gene_hgnc_id": 9304,
"hgvs_c": "c.181-5907C>G",
"hgvs_p": null,
"transcript": "NM_002717.4",
"protein_id": "NP_002708.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 447,
"cds_start": -4,
"cds_end": null,
"cds_length": 1344,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3923,
"mane_select": "ENST00000380737.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "PPP2R2A",
"gene_hgnc_id": 9304,
"hgvs_c": "c.181-5907C>G",
"hgvs_p": null,
"transcript": "ENST00000380737.8",
"protein_id": "ENSP00000370113.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 447,
"cds_start": -4,
"cds_end": null,
"cds_length": 1344,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3923,
"mane_select": "NM_002717.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "PPP2R2A",
"gene_hgnc_id": 9304,
"hgvs_c": "c.211-5907C>G",
"hgvs_p": null,
"transcript": "NM_001177591.2",
"protein_id": "NP_001171062.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 457,
"cds_start": -4,
"cds_end": null,
"cds_length": 1374,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3672,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "PPP2R2A",
"gene_hgnc_id": 9304,
"hgvs_c": "c.211-5907C>G",
"hgvs_p": null,
"transcript": "ENST00000315985.7",
"protein_id": "ENSP00000325074.7",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 457,
"cds_start": -4,
"cds_end": null,
"cds_length": 1374,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1878,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP2R2A",
"gene_hgnc_id": 9304,
"hgvs_c": "c.-262-5907C>G",
"hgvs_p": null,
"transcript": "ENST00000665949.1",
"protein_id": "ENSP00000499648.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 340,
"cds_start": -4,
"cds_end": null,
"cds_length": 1023,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2153,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP2R2A",
"gene_hgnc_id": 9304,
"hgvs_c": "c.-297-5907C>G",
"hgvs_p": null,
"transcript": "ENST00000660435.1",
"protein_id": "ENSP00000499441.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 288,
"cds_start": -4,
"cds_end": null,
"cds_length": 867,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2128,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PPP2R2A",
"gene_hgnc_id": 9304,
"hgvs_c": "c.-77-12540C>G",
"hgvs_p": null,
"transcript": "ENST00000524169.5",
"protein_id": "ENSP00000430320.1",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 196,
"cds_start": -4,
"cds_end": null,
"cds_length": 592,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 784,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "PPP2R2A",
"gene_hgnc_id": 9304,
"hgvs_c": "c.-297-5907C>G",
"hgvs_p": null,
"transcript": "ENST00000521557.5",
"protein_id": "ENSP00000428165.1",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": 13,
"cds_start": -4,
"cds_end": null,
"cds_length": 42,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 601,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "PPP2R2A",
"gene_hgnc_id": 9304,
"hgvs_c": "c.-297-5907C>G",
"hgvs_p": null,
"transcript": "ENST00000523925.5",
"protein_id": "ENSP00000428800.1",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 4,
"cds_start": -4,
"cds_end": null,
"cds_length": 16,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 529,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "PPP2R2A",
"gene_hgnc_id": 9304,
"hgvs_c": "c.-297-5907C>G",
"hgvs_p": null,
"transcript": "ENST00000522535.5",
"protein_id": "ENSP00000428705.1",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": 2,
"cds_start": -4,
"cds_end": null,
"cds_length": 10,
"cdna_start": null,
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"cdna_length": 653,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
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"gene_symbol": "PPP2R2A",
"gene_hgnc_id": 9304,
"hgvs_c": "n.*145-5907C>G",
"hgvs_p": null,
"transcript": "ENST00000518254.5",
"protein_id": "ENSP00000428164.1",
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"aa_start": null,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"hgvs_c": "n.181-5907C>G",
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"transcript": "ENST00000518397.5",
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},
{
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"strand": true,
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],
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"gene_symbol": "PPP2R2A",
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"hgvs_c": "n.268-5907C>G",
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"transcript": "ENST00000519439.5",
"protein_id": null,
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},
{
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"strand": true,
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],
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},
{
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],
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"transcript": "ENST00000520329.5",
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},
{
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"strand": true,
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],
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"gene_symbol": "PPP2R2A",
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},
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],
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"gene_symbol": "PPP2R2A",
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"hgvs_c": "n.321-5907C>G",
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},
{
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],
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"exon_count": 5,
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"gene_symbol": "PPP2R2A",
"gene_hgnc_id": 9304,
"hgvs_c": "n.324-2038C>G",
"hgvs_p": null,
"transcript": "ENST00000522482.5",
"protein_id": null,
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},
{
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],
"exon_rank": null,
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"exon_count": 6,
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"gene_symbol": "PPP2R2A",
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"hgvs_c": "n.218-5907C>G",
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},
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],
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},
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],
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},
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"strand": true,
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],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 2,
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"gene_symbol": "PPP2R2A",
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"hgvs_c": "n.187-5907C>G",
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"transcript": "ENST00000667651.1",
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"biotype": null,
"feature": null
},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 10,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "PPP2R2A",
"gene_hgnc_id": 9304,
"hgvs_c": "c.208-5907C>G",
"hgvs_p": null,
"transcript": "XM_011544565.2",
"protein_id": "XP_011542867.1",
"transcript_support_level": null,
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},
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}
],
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}