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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 8-28527195-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=28527195&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "8",
"pos": 28527195,
"ref": "A",
"alt": "G",
"effect": "synonymous_variant",
"transcript": "ENST00000240093.8",
"consequences": [
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.435A>G",
"hgvs_p": "p.Leu145Leu",
"transcript": "NM_017412.4",
"protein_id": "NP_059108.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 666,
"cds_start": 435,
"cds_end": null,
"cds_length": 2001,
"cdna_start": 957,
"cdna_end": null,
"cdna_length": 13770,
"mane_select": "ENST00000240093.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.435A>G",
"hgvs_p": "p.Leu145Leu",
"transcript": "ENST00000240093.8",
"protein_id": "ENSP00000240093.3",
"transcript_support_level": 1,
"aa_start": 145,
"aa_end": null,
"aa_length": 666,
"cds_start": 435,
"cds_end": null,
"cds_length": 2001,
"cdna_start": 957,
"cdna_end": null,
"cdna_length": 13770,
"mane_select": "NM_017412.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.-139A>G",
"hgvs_p": null,
"transcript": "NM_001412909.1",
"protein_id": "NP_001399838.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 475,
"cds_start": -4,
"cds_end": null,
"cds_length": 1428,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 13660,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.-139A>G",
"hgvs_p": null,
"transcript": "NM_001412910.1",
"protein_id": "NP_001399839.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 475,
"cds_start": -4,
"cds_end": null,
"cds_length": 1428,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 13706,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.-139A>G",
"hgvs_p": null,
"transcript": "NM_001412919.1",
"protein_id": "NP_001399848.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 475,
"cds_start": -4,
"cds_end": null,
"cds_length": 1428,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 12994,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.504A>G",
"hgvs_p": "p.Leu168Leu",
"transcript": "NM_001412905.1",
"protein_id": "NP_001399834.1",
"transcript_support_level": null,
"aa_start": 168,
"aa_end": null,
"aa_length": 689,
"cds_start": 504,
"cds_end": null,
"cds_length": 2070,
"cdna_start": 1026,
"cdna_end": null,
"cdna_length": 13839,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.504A>G",
"hgvs_p": "p.Leu168Leu",
"transcript": "NM_001412917.1",
"protein_id": "NP_001399846.1",
"transcript_support_level": null,
"aa_start": 168,
"aa_end": null,
"aa_length": 689,
"cds_start": 504,
"cds_end": null,
"cds_length": 2070,
"cdna_start": 980,
"cdna_end": null,
"cdna_length": 13793,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.435A>G",
"hgvs_p": "p.Leu145Leu",
"transcript": "NM_001412911.1",
"protein_id": "NP_001399840.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 666,
"cds_start": 435,
"cds_end": null,
"cds_length": 2001,
"cdna_start": 952,
"cdna_end": null,
"cdna_length": 13765,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.435A>G",
"hgvs_p": "p.Leu145Leu",
"transcript": "NM_145866.2",
"protein_id": "NP_665873.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 666,
"cds_start": 435,
"cds_end": null,
"cds_length": 2001,
"cdna_start": 911,
"cdna_end": null,
"cdna_length": 13724,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.435A>G",
"hgvs_p": "p.Leu145Leu",
"transcript": "ENST00000537916.2",
"protein_id": "ENSP00000437489.1",
"transcript_support_level": 2,
"aa_start": 145,
"aa_end": null,
"aa_length": 666,
"cds_start": 435,
"cds_end": null,
"cds_length": 2001,
"cdna_start": 918,
"cdna_end": null,
"cdna_length": 13740,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.252A>G",
"hgvs_p": "p.Leu84Leu",
"transcript": "NM_001412927.1",
"protein_id": "NP_001399856.1",
"transcript_support_level": null,
"aa_start": 84,
"aa_end": null,
"aa_length": 605,
"cds_start": 252,
"cds_end": null,
"cds_length": 1818,
"cdna_start": 804,
"cdna_end": null,
"cdna_length": 13617,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.249A>G",
"hgvs_p": "p.Leu83Leu",
"transcript": "NM_001412924.1",
"protein_id": "NP_001399853.1",
"transcript_support_level": null,
"aa_start": 83,
"aa_end": null,
"aa_length": 604,
"cds_start": 249,
"cds_end": null,
"cds_length": 1815,
"cdna_start": 1079,
"cdna_end": null,
"cdna_length": 13892,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.249A>G",
"hgvs_p": "p.Leu83Leu",
"transcript": "NM_001412925.1",
"protein_id": "NP_001399854.1",
"transcript_support_level": null,
"aa_start": 83,
"aa_end": null,
"aa_length": 604,
"cds_start": 249,
"cds_end": null,
"cds_length": 1815,
"cdna_start": 1125,
"cdna_end": null,
"cdna_length": 13938,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.234A>G",
"hgvs_p": "p.Leu78Leu",
"transcript": "NM_001412906.1",
"protein_id": "NP_001399835.1",
"transcript_support_level": null,
"aa_start": 78,
"aa_end": null,
"aa_length": 599,
"cds_start": 234,
"cds_end": null,
"cds_length": 1800,
"cdna_start": 378,
"cdna_end": null,
"cdna_length": 13191,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.81A>G",
"hgvs_p": "p.Leu27Leu",
"transcript": "NM_001412922.1",
"protein_id": "NP_001399851.1",
"transcript_support_level": null,
"aa_start": 27,
"aa_end": null,
"aa_length": 548,
"cds_start": 81,
"cds_end": null,
"cds_length": 1647,
"cdna_start": 714,
"cdna_end": null,
"cdna_length": 13527,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.54A>G",
"hgvs_p": "p.Leu18Leu",
"transcript": "NM_001412912.1",
"protein_id": "NP_001399841.1",
"transcript_support_level": null,
"aa_start": 18,
"aa_end": null,
"aa_length": 539,
"cds_start": 54,
"cds_end": null,
"cds_length": 1620,
"cdna_start": 907,
"cdna_end": null,
"cdna_length": 13720,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.54A>G",
"hgvs_p": "p.Leu18Leu",
"transcript": "NM_001412913.1",
"protein_id": "NP_001399842.1",
"transcript_support_level": null,
"aa_start": 18,
"aa_end": null,
"aa_length": 539,
"cds_start": 54,
"cds_end": null,
"cds_length": 1620,
"cdna_start": 953,
"cdna_end": null,
"cdna_length": 13766,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.234A>G",
"hgvs_p": "p.Leu78Leu",
"transcript": "XM_017013841.2",
"protein_id": "XP_016869330.1",
"transcript_support_level": null,
"aa_start": 78,
"aa_end": null,
"aa_length": 599,
"cds_start": 234,
"cds_end": null,
"cds_length": 1800,
"cdna_start": 326,
"cdna_end": null,
"cdna_length": 13139,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.435A>G",
"hgvs_p": "p.Leu145Leu",
"transcript": "XM_047422238.1",
"protein_id": "XP_047278194.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 522,
"cds_start": 435,
"cds_end": null,
"cds_length": 1569,
"cdna_start": 957,
"cdna_end": null,
"cdna_length": 2166,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.435A>G",
"hgvs_p": "p.Leu145Leu",
"transcript": "XM_017013842.2",
"protein_id": "XP_016869331.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 502,
"cds_start": 435,
"cds_end": null,
"cds_length": 1509,
"cdna_start": 957,
"cdna_end": null,
"cdna_length": 2043,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.435A>G",
"hgvs_p": "p.Leu145Leu",
"transcript": "XM_017013843.2",
"protein_id": "XP_016869332.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 491,
"cds_start": 435,
"cds_end": null,
"cds_length": 1476,
"cdna_start": 957,
"cdna_end": null,
"cdna_length": 2084,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
"hgvs_c": "c.435A>G",
"hgvs_p": "p.Leu145Leu",
"transcript": "XM_047422239.1",
"protein_id": "XP_047278195.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 491,
"cds_start": 435,
"cds_end": null,
"cds_length": 1476,
"cdna_start": 911,
"cdna_end": null,
"cdna_length": 2038,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZD3",
"gene_hgnc_id": 4041,
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}