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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 8-28717074-C-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=28717074&ref=C&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "8",
      "pos": 28717074,
      "ref": "C",
      "alt": "A",
      "effect": "synonymous_variant",
      "transcript": "ENST00000220562.9",
      "consequences": [
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "c.1015C>A",
          "hgvs_p": "p.Arg339Arg",
          "transcript": "NM_001440.4",
          "protein_id": "NP_001431.1",
          "transcript_support_level": null,
          "aa_start": 339,
          "aa_end": null,
          "aa_length": 919,
          "cds_start": 1015,
          "cds_end": null,
          "cds_length": 2760,
          "cdna_start": 1743,
          "cdna_end": null,
          "cdna_length": 8221,
          "mane_select": "ENST00000220562.9",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "c.1015C>A",
          "hgvs_p": "p.Arg339Arg",
          "transcript": "ENST00000220562.9",
          "protein_id": "ENSP00000220562.4",
          "transcript_support_level": 1,
          "aa_start": 339,
          "aa_end": null,
          "aa_length": 919,
          "cds_start": 1015,
          "cds_end": null,
          "cds_length": 2760,
          "cdna_start": 1743,
          "cdna_end": null,
          "cdna_length": 8221,
          "mane_select": "NM_001440.4",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "c.1015C>A",
          "hgvs_p": "p.Arg339Arg",
          "transcript": "NM_001437797.1",
          "protein_id": "NP_001424726.1",
          "transcript_support_level": null,
          "aa_start": 339,
          "aa_end": null,
          "aa_length": 919,
          "cds_start": 1015,
          "cds_end": null,
          "cds_length": 2760,
          "cdna_start": 1649,
          "cdna_end": null,
          "cdna_length": 9090,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "c.1015C>A",
          "hgvs_p": "p.Arg339Arg",
          "transcript": "NM_001438399.1",
          "protein_id": "NP_001425328.1",
          "transcript_support_level": null,
          "aa_start": 339,
          "aa_end": null,
          "aa_length": 919,
          "cds_start": 1015,
          "cds_end": null,
          "cds_length": 2760,
          "cdna_start": 1659,
          "cdna_end": null,
          "cdna_length": 9100,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "c.1015C>A",
          "hgvs_p": "p.Arg339Arg",
          "transcript": "NM_001438400.1",
          "protein_id": "NP_001425329.1",
          "transcript_support_level": null,
          "aa_start": 339,
          "aa_end": null,
          "aa_length": 919,
          "cds_start": 1015,
          "cds_end": null,
          "cds_length": 2760,
          "cdna_start": 1752,
          "cdna_end": null,
          "cdna_length": 9193,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "c.1015C>A",
          "hgvs_p": "p.Arg339Arg",
          "transcript": "NM_001438401.1",
          "protein_id": "NP_001425330.1",
          "transcript_support_level": null,
          "aa_start": 339,
          "aa_end": null,
          "aa_length": 919,
          "cds_start": 1015,
          "cds_end": null,
          "cds_length": 2760,
          "cdna_start": 1790,
          "cdna_end": null,
          "cdna_length": 9231,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "c.1015C>A",
          "hgvs_p": "p.Arg339Arg",
          "transcript": "NM_001438402.1",
          "protein_id": "NP_001425331.1",
          "transcript_support_level": null,
          "aa_start": 339,
          "aa_end": null,
          "aa_length": 919,
          "cds_start": 1015,
          "cds_end": null,
          "cds_length": 2760,
          "cdna_start": 1787,
          "cdna_end": null,
          "cdna_length": 9228,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "c.1015C>A",
          "hgvs_p": "p.Arg339Arg",
          "transcript": "NM_001438751.1",
          "protein_id": "NP_001425680.1",
          "transcript_support_level": null,
          "aa_start": 339,
          "aa_end": null,
          "aa_length": 919,
          "cds_start": 1015,
          "cds_end": null,
          "cds_length": 2760,
          "cdna_start": 1778,
          "cdna_end": null,
          "cdna_length": 9219,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "c.1015C>A",
          "hgvs_p": "p.Arg339Arg",
          "transcript": "NM_001438753.1",
          "protein_id": "NP_001425682.1",
          "transcript_support_level": null,
          "aa_start": 339,
          "aa_end": null,
          "aa_length": 919,
          "cds_start": 1015,
          "cds_end": null,
          "cds_length": 2760,
          "cdna_start": 1906,
          "cdna_end": null,
          "cdna_length": 9347,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "c.1015C>A",
          "hgvs_p": "p.Arg339Arg",
          "transcript": "ENST00000696177.1",
          "protein_id": "ENSP00000512467.1",
          "transcript_support_level": null,
          "aa_start": 339,
          "aa_end": null,
          "aa_length": 919,
          "cds_start": 1015,
          "cds_end": null,
          "cds_length": 2760,
          "cdna_start": 1569,
          "cdna_end": null,
          "cdna_length": 9009,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
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          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "c.1015C>A",
          "hgvs_p": "p.Arg339Arg",
          "transcript": "ENST00000696178.1",
          "protein_id": "ENSP00000512468.1",
          "transcript_support_level": null,
          "aa_start": 339,
          "aa_end": null,
          "aa_length": 919,
          "cds_start": 1015,
          "cds_end": null,
          "cds_length": 2760,
          "cdna_start": 1663,
          "cdna_end": null,
          "cdna_length": 9103,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
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        },
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
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          "gene_symbol": "EXTL3",
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          "hgvs_c": "c.1015C>A",
          "hgvs_p": "p.Arg339Arg",
          "transcript": "ENST00000696184.1",
          "protein_id": "ENSP00000512473.1",
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          "cdna_start": 1683,
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        {
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          "strand": true,
          "consequences": [
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          ],
          "exon_rank": 2,
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          "exon_count": 6,
          "intron_rank": null,
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          "gene_symbol": "EXTL3",
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          "hgvs_c": "c.1015C>A",
          "hgvs_p": "p.Arg339Arg",
          "transcript": "ENST00000696186.1",
          "protein_id": "ENSP00000512474.1",
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          "cdna_start": 1552,
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        {
          "aa_ref": "R",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
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          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "c.1015C>A",
          "hgvs_p": "p.Arg339Arg",
          "transcript": "ENST00000696180.1",
          "protein_id": "ENSP00000512470.1",
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          "cdna_start": 1744,
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        },
        {
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          "protein_coding": true,
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          ],
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          "hgvs_c": "c.1015C>A",
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        {
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          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
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          "exon_count": 7,
          "intron_rank": null,
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          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "c.1015C>A",
          "hgvs_p": "p.Arg339Arg",
          "transcript": "XM_024447096.2",
          "protein_id": "XP_024302864.1",
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          "cdna_start": 1607,
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        {
          "aa_ref": "R",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": 3,
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          "exon_count": 7,
          "intron_rank": null,
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          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "c.1015C>A",
          "hgvs_p": "p.Arg339Arg",
          "transcript": "XM_047421515.1",
          "protein_id": "XP_047277471.1",
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        {
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          "strand": true,
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          ],
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          "intron_rank": null,
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          "gene_symbol": "EXTL3",
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          "hgvs_c": "c.1015C>A",
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          "transcript": "XM_047421517.1",
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        },
        {
          "aa_ref": null,
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          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
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          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "n.1015C>A",
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          "feature": null
        },
        {
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": 3,
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          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "n.1648C>A",
          "hgvs_p": null,
          "transcript": "ENST00000696185.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 3026,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "c.-114-14149C>A",
          "hgvs_p": null,
          "transcript": "ENST00000696182.1",
          "protein_id": "ENSP00000512472.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": 165,
          "cds_start": -4,
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          "cds_length": 498,
          "cdna_start": null,
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          "cdna_length": 6464,
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          "feature": null
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "n.631+1008C>A",
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          "transcript": "ENST00000519886.5",
          "protein_id": null,
          "transcript_support_level": 3,
          "aa_start": null,
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          "aa_length": null,
          "cds_start": -4,
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          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 803,
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          "feature": null
        },
        {
          "aa_ref": null,
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          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "n.146+6571C>A",
          "hgvs_p": null,
          "transcript": "ENST00000521532.5",
          "protein_id": null,
          "transcript_support_level": 4,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 517,
          "mane_select": null,
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          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
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          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 4,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "n.211+177C>A",
          "hgvs_p": null,
          "transcript": "ENST00000522698.1",
          "protein_id": "ENSP00000428352.1",
          "transcript_support_level": 4,
          "aa_start": null,
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          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 565,
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        },
        {
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          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 5,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "n.160-14149C>A",
          "hgvs_p": null,
          "transcript": "NR_073468.2",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": null,
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          "cdna_start": null,
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          "cdna_length": 5504,
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          "feature": null
        },
        {
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          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "EXTL3",
          "gene_hgnc_id": 3518,
          "hgvs_c": "n.735+1008C>A",
          "hgvs_p": null,
          "transcript": "NR_073469.2",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1762,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        }
      ],
      "gene_symbol": "EXTL3",
      "gene_hgnc_id": 3518,
      "dbsnp": "rs747676107",
      "frequency_reference_population": 0.000035314104,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 57,
      "gnomad_exomes_af": 0.0000369386,
      "gnomad_genomes_af": 0.0000197106,
      "gnomad_exomes_ac": 54,
      "gnomad_genomes_ac": 3,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": -0.17000000178813934,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "BayesDel_noAF",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.17,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 3.781,
      "phylop100way_prediction": "Uncertain_significance",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -3,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "BP4,BP6_Moderate",
      "acmg_by_gene": [
        {
          "score": -3,
          "benign_score": 3,
          "pathogenic_score": 0,
          "criteria": [
            "BP4",
            "BP6_Moderate"
          ],
          "verdict": "Likely_benign",
          "transcript": "ENST00000220562.9",
          "gene_symbol": "EXTL3",
          "hgnc_id": 3518,
          "effects": [
            "synonymous_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.1015C>A",
          "hgvs_p": "p.Arg339Arg"
        }
      ],
      "clinvar_disease": "not provided",
      "clinvar_classification": "Likely benign",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "LB:1",
      "phenotype_combined": "not provided",
      "pathogenicity_classification_combined": "Likely benign",
      "custom_annotations": null
    }
  ],
  "message": null
}