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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 8-29027953-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=29027953&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "8",
"pos": 29027953,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000287701.15",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "HMBOX1",
"gene_hgnc_id": 26137,
"hgvs_c": "c.851+9040T>C",
"hgvs_p": null,
"transcript": "NM_001135726.3",
"protein_id": "NP_001129198.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 420,
"cds_start": -4,
"cds_end": null,
"cds_length": 1263,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3711,
"mane_select": "ENST00000287701.15",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "HMBOX1",
"gene_hgnc_id": 26137,
"hgvs_c": "c.851+9040T>C",
"hgvs_p": null,
"transcript": "ENST00000287701.15",
"protein_id": "ENSP00000287701.10",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 420,
"cds_start": -4,
"cds_end": null,
"cds_length": 1263,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3711,
"mane_select": "NM_001135726.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "HMBOX1",
"gene_hgnc_id": 26137,
"hgvs_c": "c.851+9040T>C",
"hgvs_p": null,
"transcript": "ENST00000397358.7",
"protein_id": "ENSP00000380516.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 420,
"cds_start": -4,
"cds_end": null,
"cds_length": 1263,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4082,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "HMBOX1",
"gene_hgnc_id": 26137,
"hgvs_c": "c.851+9040T>C",
"hgvs_p": null,
"transcript": "ENST00000523613.5",
"protein_id": "ENSP00000452827.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 396,
"cds_start": -4,
"cds_end": null,
"cds_length": 1191,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1730,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LOC105379346",
"gene_hgnc_id": null,
"hgvs_c": "n.10307A>G",
"hgvs_p": null,
"transcript": "XR_007060871.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 19347,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "HMBOX1",
"gene_hgnc_id": 26137,
"hgvs_c": "c.851+9040T>C",
"hgvs_p": null,
"transcript": "NM_001324383.2",
"protein_id": "NP_001311312.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 444,
"cds_start": -4,
"cds_end": null,
"cds_length": 1335,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3783,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "HMBOX1",
"gene_hgnc_id": 26137,
"hgvs_c": "c.851+9040T>C",
"hgvs_p": null,
"transcript": "NM_001324384.1",
"protein_id": "NP_001311313.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 444,
"cds_start": -4,
"cds_end": null,
"cds_length": 1335,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3819,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "HMBOX1",
"gene_hgnc_id": 26137,
"hgvs_c": "c.851+9040T>C",
"hgvs_p": null,
"transcript": "NM_001330498.2",
"protein_id": "NP_001317427.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 443,
"cds_start": -4,
"cds_end": null,
"cds_length": 1332,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3780,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "HMBOX1",
"gene_hgnc_id": 26137,
"hgvs_c": "c.851+9040T>C",
"hgvs_p": null,
"transcript": "ENST00000524238.3",
"protein_id": "ENSP00000430110.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 443,
"cds_start": -4,
"cds_end": null,
"cds_length": 1332,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1731,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "HMBOX1",
"gene_hgnc_id": 26137,
"hgvs_c": "c.851+9040T>C",
"hgvs_p": null,
"transcript": "NM_001324385.2",
"protein_id": "NP_001311314.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 442,
"cds_start": -4,
"cds_end": null,
"cds_length": 1329,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3777,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "HMBOX1",
"gene_hgnc_id": 26137,
"hgvs_c": "c.851+9040T>C",
"hgvs_p": null,
"transcript": "NM_001324382.2",
"protein_id": "NP_001311311.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 7,
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"gene_symbol": "HMBOX1",
"gene_hgnc_id": 26137,
"hgvs_c": "c.851+9040T>C",
"hgvs_p": null,
"transcript": "NM_024567.4",
"protein_id": "NP_078843.2",
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"cds_start": -4,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 6,
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"gene_symbol": "HMBOX1",
"gene_hgnc_id": 26137,
"hgvs_c": "c.851+9040T>C",
"hgvs_p": null,
"transcript": "NM_001324386.2",
"protein_id": "NP_001311315.1",
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"aa_start": null,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 6,
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"gene_symbol": "HMBOX1",
"gene_hgnc_id": 26137,
"hgvs_c": "c.851+9040T>C",
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"transcript": "NM_001324387.2",
"protein_id": "NP_001311316.1",
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},
{
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],
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"gene_symbol": "HMBOX1",
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"hgvs_c": "c.851+9040T>C",
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"transcript": "NM_001324388.2",
"protein_id": "NP_001311317.1",
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},
{
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"protein_coding": true,
"strand": true,
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],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 6,
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"gene_symbol": "HMBOX1",
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"hgvs_c": "c.851+9040T>C",
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"transcript": "NM_001324389.2",
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},
{
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],
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"gene_symbol": "HMBOX1",
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"hgvs_c": "c.851+9040T>C",
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"transcript": "NM_001324390.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 6,
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"gene_symbol": "HMBOX1",
"gene_hgnc_id": 26137,
"hgvs_c": "c.851+9040T>C",
"hgvs_p": null,
"transcript": "NM_001324391.2",
"protein_id": "NP_001311320.1",
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},
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],
"exon_rank": null,
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"intron_rank": 6,
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"gene_symbol": "HMBOX1",
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"transcript": "NM_001324392.1",
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],
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"gene_symbol": "HMBOX1",
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"hgvs_c": "c.851+9040T>C",
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},
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],
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"intron_rank": 7,
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"gene_symbol": "HMBOX1",
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},
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "HMBOX1",
"gene_hgnc_id": 26137,
"hgvs_c": "c.851+9040T>C",
"hgvs_p": null,
"transcript": "NM_001324394.2",
"protein_id": "NP_001311323.1",
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "HMBOX1",
"gene_hgnc_id": 26137,
"hgvs_c": "c.851+9040T>C",
"hgvs_p": null,
"transcript": "ENST00000355231.9",
"protein_id": "ENSP00000475196.1",
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