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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 8-38738877-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=38738877&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "8",
"pos": 38738877,
"ref": "G",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_001352778.2",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TACC1",
"gene_hgnc_id": 11522,
"hgvs_c": "c.-674-3474G>C",
"hgvs_p": null,
"transcript": "ENST00000518415.5",
"protein_id": "ENSP00000428706.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 731,
"cds_start": null,
"cds_end": null,
"cds_length": 2196,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3011,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000518415.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TACC1",
"gene_hgnc_id": 11522,
"hgvs_c": "c.-425+10206G>C",
"hgvs_p": null,
"transcript": "ENST00000519416.5",
"protein_id": "ENSP00000428687.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 609,
"cds_start": null,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5510,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000519416.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TACC1",
"gene_hgnc_id": 11522,
"hgvs_c": "c.-79-3474G>C",
"hgvs_p": null,
"transcript": "NM_001352778.2",
"protein_id": "NP_001339707.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 821,
"cds_start": null,
"cds_end": null,
"cds_length": 2466,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7640,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001352778.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TACC1",
"gene_hgnc_id": 11522,
"hgvs_c": "c.-27+10206G>C",
"hgvs_p": null,
"transcript": "ENST00000885325.1",
"protein_id": "ENSP00000555384.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 817,
"cds_start": null,
"cds_end": null,
"cds_length": 2454,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2969,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885325.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TACC1",
"gene_hgnc_id": 11522,
"hgvs_c": "c.-27+10206G>C",
"hgvs_p": null,
"transcript": "ENST00000885321.1",
"protein_id": "ENSP00000555380.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 805,
"cds_start": null,
"cds_end": null,
"cds_length": 2418,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5388,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885321.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TACC1",
"gene_hgnc_id": 11522,
"hgvs_c": "c.-88+10206G>C",
"hgvs_p": null,
"transcript": "ENST00000885324.1",
"protein_id": "ENSP00000555383.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 805,
"cds_start": null,
"cds_end": null,
"cds_length": 2418,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5355,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885324.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TACC1",
"gene_hgnc_id": 11522,
"hgvs_c": "c.-27+1362G>C",
"hgvs_p": null,
"transcript": "ENST00000885326.1",
"protein_id": "ENSP00000555385.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 805,
"cds_start": null,
"cds_end": null,
"cds_length": 2418,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3388,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885326.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TACC1",
"gene_hgnc_id": 11522,
"hgvs_c": "c.-127-3474G>C",
"hgvs_p": null,
"transcript": "ENST00000885329.1",
"protein_id": "ENSP00000555388.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 805,
"cds_start": null,
"cds_end": null,
"cds_length": 2418,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2745,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885329.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TACC1",
"gene_hgnc_id": 11522,
"hgvs_c": "c.-79-3474G>C",
"hgvs_p": null,
"transcript": "NM_001352780.2",
"protein_id": "NP_001339709.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 792,
"cds_start": null,
"cds_end": null,
"cds_length": 2379,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7553,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001352780.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TACC1",
"gene_hgnc_id": 11522,
"hgvs_c": "c.-27+10206G>C",
"hgvs_p": null,
"transcript": "ENST00000885327.1",
"protein_id": "ENSP00000555386.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 788,
"cds_start": null,
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"cds_length": 2367,
"cdna_start": null,
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"cdna_length": 2602,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885327.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
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"gene_symbol": "TACC1",
"gene_hgnc_id": 11522,
"hgvs_c": "c.-27+10206G>C",
"hgvs_p": null,
"transcript": "ENST00000943627.1",
"protein_id": "ENSP00000613686.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"feature": "ENST00000943627.1"
},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 14,
"intron_rank": 1,
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"gene_symbol": "TACC1",
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"hgvs_c": "c.-27+10206G>C",
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"transcript": "ENST00000943628.1",
"protein_id": "ENSP00000613687.1",
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"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000943628.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 14,
"intron_rank": 1,
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"gene_symbol": "TACC1",
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"hgvs_c": "c.-48-3474G>C",
"hgvs_p": null,
"transcript": "NM_001352787.2",
"protein_id": "NP_001339716.1",
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"aa_start": null,
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"cdna_start": null,
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},
{
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"strand": true,
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],
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"intron_rank": 1,
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"gene_symbol": "TACC1",
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"hgvs_c": "c.-48-3474G>C",
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},
{
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"strand": true,
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"intron_variant"
],
"exon_rank": null,
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"exon_count": 15,
"intron_rank": 1,
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"gene_symbol": "TACC1",
"gene_hgnc_id": 11522,
"hgvs_c": "c.-674-3474G>C",
"hgvs_p": null,
"transcript": "NM_001352786.2",
"protein_id": "NP_001339715.1",
"transcript_support_level": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "NM_001352786.2"
},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "TACC1",
"gene_hgnc_id": 11522,
"hgvs_c": "c.-425+10206G>C",
"hgvs_p": null,
"transcript": "NM_001352788.2",
"protein_id": "NP_001339717.1",
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"biotype": "protein_coding",
"feature": "NM_001352788.2"
},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 13,
"intron_rank": 1,
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"gene_symbol": "TACC1",
"gene_hgnc_id": 11522,
"hgvs_c": "c.-425+10206G>C",
"hgvs_p": null,
"transcript": "NM_001146216.3",
"protein_id": "NP_001139688.1",
"transcript_support_level": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "NM_001146216.3"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TACC1",
"gene_hgnc_id": 11522,
"hgvs_c": "c.-309+10206G>C",
"hgvs_p": null,
"transcript": "NM_001352789.2",
"protein_id": "NP_001339718.1",
"transcript_support_level": null,
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"cds_start": null,
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},
{
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"strand": true,
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],
"exon_rank": null,
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"exon_count": 13,
"intron_rank": 1,
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"gene_symbol": "TACC1",
"gene_hgnc_id": 11522,
"hgvs_c": "c.-425+10206G>C",
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"transcript": "ENST00000520615.5",
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},
{
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"strand": true,
"consequences": [
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],
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"gene_symbol": "TACC1",
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"hgvs_c": "c.-425+10206G>C",
"hgvs_p": null,
"transcript": "NM_001352792.2",
"protein_id": "NP_001339721.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "TACC1",
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"hgvs_c": "c.-309+10206G>C",
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"transcript": "NM_001352793.2",
"protein_id": "NP_001339722.1",
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001352793.2"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TACC1",
"gene_hgnc_id": 11522,
"hgvs_c": "c.-425+10206G>C",
"hgvs_p": null,
"transcript": "NM_001352794.2",
"protein_id": "NP_001339723.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 609,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001352794.2"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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{
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"verdict": "Likely_benign",
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}
],
"message": null
}