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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 8-50658612-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=50658612&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "8",
"pos": 50658612,
"ref": "G",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "ENST00000642720.2",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "c.987G>A",
"hgvs_p": "p.Thr329Thr",
"transcript": "NM_018967.5",
"protein_id": "NP_061840.1",
"transcript_support_level": null,
"aa_start": 329,
"aa_end": null,
"aa_length": 517,
"cds_start": 987,
"cds_end": null,
"cds_length": 1554,
"cdna_start": 1914,
"cdna_end": null,
"cdna_length": 6344,
"mane_select": "ENST00000642720.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "c.987G>A",
"hgvs_p": "p.Thr329Thr",
"transcript": "ENST00000642720.2",
"protein_id": "ENSP00000493900.1",
"transcript_support_level": null,
"aa_start": 329,
"aa_end": null,
"aa_length": 517,
"cds_start": 987,
"cds_end": null,
"cds_length": 1554,
"cdna_start": 1914,
"cdna_end": null,
"cdna_length": 6344,
"mane_select": "NM_018967.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "c.987G>A",
"hgvs_p": "p.Thr329Thr",
"transcript": "ENST00000518864.5",
"protein_id": "ENSP00000429276.1",
"transcript_support_level": 1,
"aa_start": 329,
"aa_end": null,
"aa_length": 517,
"cds_start": 987,
"cds_end": null,
"cds_length": 1554,
"cdna_start": 1358,
"cdna_end": null,
"cdna_length": 1925,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "c.987G>A",
"hgvs_p": "p.Thr329Thr",
"transcript": "ENST00000517473.5",
"protein_id": "ENSP00000431123.1",
"transcript_support_level": 1,
"aa_start": 329,
"aa_end": null,
"aa_length": 480,
"cds_start": 987,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1209,
"cdna_end": null,
"cdna_length": 1703,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "n.987G>A",
"hgvs_p": null,
"transcript": "ENST00000520825.5",
"protein_id": "ENSP00000428558.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1714,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "c.987G>A",
"hgvs_p": "p.Thr329Thr",
"transcript": "NM_001287813.3",
"protein_id": "NP_001274742.1",
"transcript_support_level": null,
"aa_start": 329,
"aa_end": null,
"aa_length": 517,
"cds_start": 987,
"cds_end": null,
"cds_length": 1554,
"cdna_start": 1351,
"cdna_end": null,
"cdna_length": 5781,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "c.987G>A",
"hgvs_p": "p.Thr329Thr",
"transcript": "NM_001321773.2",
"protein_id": "NP_001308702.1",
"transcript_support_level": null,
"aa_start": 329,
"aa_end": null,
"aa_length": 517,
"cds_start": 987,
"cds_end": null,
"cds_length": 1554,
"cdna_start": 1839,
"cdna_end": null,
"cdna_length": 6269,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "c.987G>A",
"hgvs_p": "p.Thr329Thr",
"transcript": "NM_001287814.3",
"protein_id": "NP_001274743.1",
"transcript_support_level": null,
"aa_start": 329,
"aa_end": null,
"aa_length": 480,
"cds_start": 987,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1839,
"cdna_end": null,
"cdna_length": 6158,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "c.852G>A",
"hgvs_p": "p.Thr284Thr",
"transcript": "ENST00000642164.1",
"protein_id": "ENSP00000494929.1",
"transcript_support_level": null,
"aa_start": 284,
"aa_end": null,
"aa_length": 472,
"cds_start": 852,
"cds_end": null,
"cds_length": 1419,
"cdna_start": 1582,
"cdna_end": null,
"cdna_length": 2182,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "c.987G>A",
"hgvs_p": "p.Thr329Thr",
"transcript": "NM_001321775.2",
"protein_id": "NP_001308704.1",
"transcript_support_level": null,
"aa_start": 329,
"aa_end": null,
"aa_length": 435,
"cds_start": 987,
"cds_end": null,
"cds_length": 1308,
"cdna_start": 1351,
"cdna_end": null,
"cdna_length": 1850,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "c.987G>A",
"hgvs_p": "p.Thr329Thr",
"transcript": "NM_001321776.2",
"protein_id": "NP_001308705.1",
"transcript_support_level": null,
"aa_start": 329,
"aa_end": null,
"aa_length": 435,
"cds_start": 987,
"cds_end": null,
"cds_length": 1308,
"cdna_start": 1914,
"cdna_end": null,
"cdna_length": 2413,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "c.987G>A",
"hgvs_p": "p.Thr329Thr",
"transcript": "NM_001321777.2",
"protein_id": "NP_001308706.1",
"transcript_support_level": null,
"aa_start": 329,
"aa_end": null,
"aa_length": 435,
"cds_start": 987,
"cds_end": null,
"cds_length": 1308,
"cdna_start": 1839,
"cdna_end": null,
"cdna_length": 2338,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "c.987G>A",
"hgvs_p": "p.Thr329Thr",
"transcript": "NM_001321778.2",
"protein_id": "NP_001308707.1",
"transcript_support_level": null,
"aa_start": 329,
"aa_end": null,
"aa_length": 435,
"cds_start": 987,
"cds_end": null,
"cds_length": 1308,
"cdna_start": 1379,
"cdna_end": null,
"cdna_length": 1878,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "c.987G>A",
"hgvs_p": "p.Thr329Thr",
"transcript": "ENST00000647273.1",
"protein_id": "ENSP00000494713.1",
"transcript_support_level": null,
"aa_start": 329,
"aa_end": null,
"aa_length": 435,
"cds_start": 987,
"cds_end": null,
"cds_length": 1308,
"cdna_start": 1377,
"cdna_end": null,
"cdna_length": 1867,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "c.930G>A",
"hgvs_p": "p.Thr310Thr",
"transcript": "ENST00000643999.1",
"protein_id": "ENSP00000495470.1",
"transcript_support_level": null,
"aa_start": 310,
"aa_end": null,
"aa_length": 416,
"cds_start": 930,
"cds_end": null,
"cds_length": 1251,
"cdna_start": 1595,
"cdna_end": null,
"cdna_length": 2074,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "c.987G>A",
"hgvs_p": "p.Thr329Thr",
"transcript": "ENST00000647073.1",
"protein_id": "ENSP00000496147.1",
"transcript_support_level": null,
"aa_start": 329,
"aa_end": null,
"aa_length": 402,
"cds_start": 987,
"cds_end": null,
"cds_length": 1209,
"cdna_start": 1623,
"cdna_end": null,
"cdna_length": 3103,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "c.987G>A",
"hgvs_p": "p.Thr329Thr",
"transcript": "ENST00000642826.1",
"protein_id": "ENSP00000494442.1",
"transcript_support_level": null,
"aa_start": 329,
"aa_end": null,
"aa_length": 398,
"cds_start": 987,
"cds_end": null,
"cds_length": 1197,
"cdna_start": 1263,
"cdna_end": null,
"cdna_length": 1473,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "c.540G>A",
"hgvs_p": "p.Thr180Thr",
"transcript": "ENST00000644093.1",
"protein_id": "ENSP00000494759.1",
"transcript_support_level": null,
"aa_start": 180,
"aa_end": null,
"aa_length": 368,
"cds_start": 540,
"cds_end": null,
"cds_length": 1107,
"cdna_start": 1240,
"cdna_end": null,
"cdna_length": 4929,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "c.651G>A",
"hgvs_p": "p.Thr217Thr",
"transcript": "ENST00000643809.1",
"protein_id": "ENSP00000495550.1",
"transcript_support_level": null,
"aa_start": 217,
"aa_end": null,
"aa_length": 323,
"cds_start": 651,
"cds_end": null,
"cds_length": 972,
"cdna_start": 1072,
"cdna_end": null,
"cdna_length": 1482,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "c.129G>A",
"hgvs_p": "p.Thr43Thr",
"transcript": "ENST00000642377.1",
"protein_id": "ENSP00000494958.1",
"transcript_support_level": null,
"aa_start": 43,
"aa_end": null,
"aa_length": 149,
"cds_start": 129,
"cds_end": null,
"cds_length": 450,
"cdna_start": 754,
"cdna_end": null,
"cdna_length": 1075,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "c.987G>A",
"hgvs_p": "p.Thr329Thr",
"transcript": "XM_017013579.2",
"protein_id": "XP_016869068.1",
"transcript_support_level": null,
"aa_start": 329,
"aa_end": null,
"aa_length": 517,
"cds_start": 987,
"cds_end": null,
"cds_length": 1554,
"cdna_start": 4693,
"cdna_end": null,
"cdna_length": 9123,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
"gene_hgnc_id": 13740,
"hgvs_c": "c.987G>A",
"hgvs_p": "p.Thr329Thr",
"transcript": "XM_017013580.3",
"protein_id": "XP_016869069.1",
"transcript_support_level": null,
"aa_start": 329,
"aa_end": null,
"aa_length": 517,
"cds_start": 987,
"cds_end": null,
"cds_length": 1554,
"cdna_start": 2072,
"cdna_end": null,
"cdna_length": 6502,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SNTG1",
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