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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 8-52213340-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=52213340&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "8",
      "pos": 52213340,
      "ref": "C",
      "alt": "T",
      "effect": "intron_variant",
      "transcript": "ENST00000689386.1",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": 7,
          "intron_rank_end": null,
          "gene_symbol": "ST18",
          "gene_hgnc_id": 18695,
          "hgvs_c": "c.55+863G>A",
          "hgvs_p": null,
          "transcript": "NM_001352837.2",
          "protein_id": "NP_001339766.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1047,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 3144,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 6302,
          "mane_select": "ENST00000689386.1",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": 7,
          "intron_rank_end": null,
          "gene_symbol": "ST18",
          "gene_hgnc_id": 18695,
          "hgvs_c": "c.55+863G>A",
          "hgvs_p": null,
          "transcript": "ENST00000689386.1",
          "protein_id": "ENSP00000509475.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1047,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 3144,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 6302,
          "mane_select": "NM_001352837.2",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": 7,
          "intron_rank_end": null,
          "gene_symbol": "ST18",
          "gene_hgnc_id": 18695,
          "hgvs_c": "c.55+863G>A",
          "hgvs_p": null,
          "transcript": "ENST00000276480.11",
          "protein_id": "ENSP00000276480.7",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1047,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 3144,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 6187,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": 7,
          "intron_rank_end": null,
          "gene_symbol": "ST18",
          "gene_hgnc_id": 18695,
          "hgvs_c": "c.55+863G>A",
          "hgvs_p": null,
          "transcript": "ENST00000517580.5",
          "protein_id": "ENSP00000428521.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 619,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1862,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2579,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": 7,
          "intron_rank_end": null,
          "gene_symbol": "ST18",
          "gene_hgnc_id": 18695,
          "hgvs_c": "n.850+863G>A",
          "hgvs_p": null,
          "transcript": "ENST00000521549.5",
          "protein_id": null,
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 955,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "ST18",
          "gene_hgnc_id": 18695,
          "hgvs_c": "n.55+863G>A",
          "hgvs_p": null,
          "transcript": "ENST00000521582.5",
          "protein_id": "ENSP00000430763.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 3928,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 21,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "ST18",
          "gene_hgnc_id": 18695,
          "hgvs_c": "n.55+863G>A",
          "hgvs_p": null,
          "transcript": "ENST00000521824.5",
          "protein_id": "ENSP00000429579.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3870,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "ST18",
          "gene_hgnc_id": 18695,
          "hgvs_c": "n.55+863G>A",
          "hgvs_p": null,
          "transcript": "ENST00000522251.5",
          "protein_id": "ENSP00000428920.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 3963,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": 7,
          "intron_rank_end": null,
          "gene_symbol": "ST18",
          "gene_hgnc_id": 18695,
          "hgvs_c": "c.55+863G>A",
          "hgvs_p": null,
          "transcript": "NM_001352826.2",
          "protein_id": "NP_001339755.1",
          "transcript_support_level": null,
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          "cds_start": -4,
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          "cdna_start": null,
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          "mane_select": null,
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        {
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          "consequences": [
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          "exon_count": 27,
          "intron_rank": 8,
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          "gene_symbol": "ST18",
          "gene_hgnc_id": 18695,
          "hgvs_c": "c.55+863G>A",
          "hgvs_p": null,
          "transcript": "NM_001352827.2",
          "protein_id": "NP_001339756.1",
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        {
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      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
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      "custom_annotations": null
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  "message": null
}