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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 8-80037711-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=80037711&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "8",
      "pos": 80037711,
      "ref": "G",
      "alt": "A",
      "effect": "3_prime_UTR_variant",
      "transcript": "ENST00000518937.6",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPD52",
          "gene_hgnc_id": 12005,
          "hgvs_c": "n.*763C>T",
          "hgvs_p": null,
          "transcript": "ENST00000517462.6",
          "protein_id": "ENSP00000429708.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2702,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPD52",
          "gene_hgnc_id": 12005,
          "hgvs_c": "c.*405C>T",
          "hgvs_p": null,
          "transcript": "NM_001025253.3",
          "protein_id": "NP_001020424.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 207,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 624,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4116,
          "mane_select": "ENST00000518937.6",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPD52",
          "gene_hgnc_id": 12005,
          "hgvs_c": "c.*405C>T",
          "hgvs_p": null,
          "transcript": "ENST00000518937.6",
          "protein_id": "ENSP00000429915.1",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 207,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 624,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4116,
          "mane_select": "NM_001025253.3",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPD52",
          "gene_hgnc_id": 12005,
          "hgvs_c": "c.*405C>T",
          "hgvs_p": null,
          "transcript": "ENST00000520527.5",
          "protein_id": "ENSP00000429309.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 247,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 744,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2638,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPD52",
          "gene_hgnc_id": 12005,
          "hgvs_c": "c.*405C>T",
          "hgvs_p": null,
          "transcript": "ENST00000448733.3",
          "protein_id": "ENSP00000410222.2",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 238,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 717,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4339,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPD52",
          "gene_hgnc_id": 12005,
          "hgvs_c": "c.*405C>T",
          "hgvs_p": null,
          "transcript": "ENST00000517427.5",
          "protein_id": "ENSP00000429351.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 233,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 702,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2596,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPD52",
          "gene_hgnc_id": 12005,
          "hgvs_c": "c.*405C>T",
          "hgvs_p": null,
          "transcript": "ENST00000379097.7",
          "protein_id": "ENSP00000368391.3",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 224,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 675,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2563,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPD52",
          "gene_hgnc_id": 12005,
          "hgvs_c": "c.*405C>T",
          "hgvs_p": null,
          "transcript": "ENST00000379096.9",
          "protein_id": "ENSP00000368390.4",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 184,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 555,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4041,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPD52",
          "gene_hgnc_id": 12005,
          "hgvs_c": "c.*405C>T",
          "hgvs_p": null,
          "transcript": "ENST00000519303.6",
          "protein_id": "ENSP00000428951.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 60,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 183,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1594,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPD52",
          "gene_hgnc_id": 12005,
          "hgvs_c": "n.*763C>T",
          "hgvs_p": null,
          "transcript": "ENST00000517462.6",
          "protein_id": "ENSP00000429708.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 2702,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
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          "canonical": true,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "ENSG00000276418",
          "gene_hgnc_id": null,
          "hgvs_c": "n.555+4909C>T",
          "hgvs_p": null,
          "transcript": "ENST00000522938.5",
          "protein_id": "ENSP00000430858.2",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
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          "cdna_start": null,
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          "cdna_length": 1527,
          "mane_select": null,
          "mane_plus": null,
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          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPD52",
          "gene_hgnc_id": 12005,
          "hgvs_c": "n.739C>T",
          "hgvs_p": null,
          "transcript": "ENST00000523395.5",
          "protein_id": null,
          "transcript_support_level": 2,
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          "cds_start": -4,
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        },
        {
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          "canonical": false,
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          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPD52",
          "gene_hgnc_id": 12005,
          "hgvs_c": "n.1596C>T",
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        },
        {
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          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
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          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPD52",
          "gene_hgnc_id": 12005,
          "hgvs_c": "n.965C>T",
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          "transcript": "NR_105034.2",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
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          "cdna_length": 3931,
          "mane_select": null,
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        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPD52",
          "gene_hgnc_id": 12005,
          "hgvs_c": "n.1151C>T",
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        {
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          ],
          "exon_rank": 8,
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          "intron_rank": null,
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          "gene_symbol": "TPD52",
          "gene_hgnc_id": 12005,
          "hgvs_c": "n.1111C>T",
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          "transcript": "NR_105036.2",
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          "mane_select": null,
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        },
        {
          "aa_ref": null,
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          "canonical": false,
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          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPD52",
          "gene_hgnc_id": 12005,
          "hgvs_c": "n.1112C>T",
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          "transcript": "NR_105037.2",
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          "mane_select": null,
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        },
        {
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          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPD52",
          "gene_hgnc_id": 12005,
          "hgvs_c": "n.1100C>T",
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        {
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          ],
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          "exon_count": 8,
          "intron_rank": null,
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          "gene_symbol": "TPD52",
          "gene_hgnc_id": 12005,
          "hgvs_c": "n.1127C>T",
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        {
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          ],
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          "exon_count": 8,
          "intron_rank": null,
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          "gene_symbol": "TPD52",
          "gene_hgnc_id": 12005,
          "hgvs_c": "c.*405C>T",
          "hgvs_p": null,
          "transcript": "NM_001287140.2",
          "protein_id": "NP_001274069.1",
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          "cdna_length": 4492,
          "mane_select": null,
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          "feature": null
        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPD52",
          "gene_hgnc_id": 12005,
          "hgvs_c": "c.*405C>T",
          "hgvs_p": null,
          "transcript": "NM_001287142.2",
          "protein_id": "NP_001274071.1",
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      "computational_source_selected": "BayesDel_noAF",
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      "acmg_classification": "Likely_benign",
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          "verdict": "Likely_benign",
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          "verdict": "Likely_benign",
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          "effects": [
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          "verdict": "Likely_benign",
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          "hgvs_c": "c.435+4909C>T",
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      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
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  ],
  "message": null
}